ChemicalBook > CAS DataBase List > 2-Fluoro-3-trifluoromethylpyridine

2-Fluoro-3-trifluoromethylpyridine

Product Name
2-Fluoro-3-trifluoromethylpyridine
CAS No.
65753-52-8
Chemical Name
2-Fluoro-3-trifluoromethylpyridine
Synonyms
2-FLUORO-TRIFLUOROMETHYLPYRIDINE;2-Floro-3-(trifluoroMethyl)pyridine;-Fluoro-3-(trifluoromethyl)pyridine;2-FLUORO-3-(TRIFLUOROMETHYL)PYRIDINE;2-FLUORO-3-(TRIFLUOROMETHOXY)PYRIDINE;Pyridine, 2-fluoro-3-(trifluoroMethyl)-;2-Fluoro-3-(trifluoromethyl)pyridine(FTF);alpha,alpha,alpha,2-Tetrafluoro-3-picoline;2-Fluoro-3-trifluoromethylpyridine Chemical Properties;2-Fluoro-3-trifluoromethylpyridine ISO 9001：2015 REACH
CBNumber
CB9317299
Molecular Formula
C6H3F4N
Formula Weight
165.09
MOL File
65753-52-8.mol
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2-Fluoro-3-trifluoromethylpyridine Property

Boiling point:
134-137 °C
Density 
1.371±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-2.86±0.10(Predicted)
form 
liquid
color 
Clear, colourless
CAS DataBase Reference
65753-52-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn,T
Risk Statements 
20/21/22-36/37/38-36-25
Safety Statements 
26-36/37/39-36-45
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
F596260
Product name
2-Fluoro-3-(trifluoromethyl)pyridine
Packaging
100mg
Price
$50
Updated
2021/12/16
TRC
Product number
F596260
Product name
2-Fluoro-3-(trifluoromethyl)pyridine
Packaging
5G
Price
$130
Updated
2021/12/16
TRC
Product number
F596260
Product name
2-Fluoro-3-(trifluoromethyl)pyridine
Packaging
25g
Price
$525
Updated
2021/12/16
Oakwood
Product number
013923
Product name
2-Fluoro-3-trifluoromethylpyridine
Purity
98%
Packaging
1g
Price
$10
Updated
2021/12/16
Matrix Scientific
Product number
011123
Product name
2-Fluoro-3-(trifluoromethyl)pyridine
Purity
98%
Packaging
1g
Price
$10
Updated
2021/12/16
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2-Fluoro-3-trifluoromethylpyridine Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

2-Fluoro-3-(trifluoromethyl)pyridine is a useful synthetic intermediate. It is used to prepare antihypertensive β-?adrenergic blocking agents. It is also used to synthesize HCV NS5B thumb pocket 2 allosteric inhibitors.

Synthesis

65753-47-1

65753-52-8

General procedure for the synthesis of 2-chloro-3-trifluoromethylpyridine from 2-chloro-3-trifluoromethylpyridine: In a desiccator, anhydrous tetramethylammonium fluoride (NMe4F, 18.6 mg, 0.2 mmol, 2 eq.) and 2-chloro-3-trifluoromethylpyridine (0.1 mmol, 1 eq.) were accurately weighed in a 4 mL sample vial, in which a micro stirring bar was placed in advance. Subsequently, N,N-dimethylformamide (DMF, 0.5 mL) was added as solvent. The sample bottle was removed from the desiccator and the reaction was stirred at room temperature for 24 hours unless otherwise stated. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the internal standard (1,3,5-trifluorobenzene, 100 μL of 0.5 M toluene solution) was added. An appropriate amount of the reaction mixture was taken and analyzed by fluorine-19 nuclear magnetic resonance (59F NMR) spectroscopy and gas chromatography-mass spectrometry (GCMS).

References

[1] Chemistry Letters, 1993, # 3, p. 509 - 512
[2] Organic Letters, 2015, vol. 17, # 8, p. 1866 - 1869
[3] Journal of Organic Chemistry, 2015, vol. 80, # 24, p. 12137 - 12145
[4] Patent: WO2017/24167, 2017, A1. Location in patent: Page/Page column 29; 33
[5] Patent: CN108003093, 2018, A. Location in patent: Paragraph 0008; 0017; 0020; 0023

2-Fluoro-3-trifluoromethylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Fluoro-3-trifluoromethylpyridine manufacturers

Hebei Zhanyao Biotechnology Co. Ltd
Product
2-Fluoro-3-trifluoromethylpyridine Chemical Properties 65753-52-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-15
Dideu Industries Group Limited
Product
2-Fluoro-3-trifluoromethylpyridine 65753-52-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-26
Career Henan Chemical Co
Product
2-Fluoro-3-trifluoromethylpyridine 65753-52-8
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2018-12-20

65753-52-8, 2-Fluoro-3-trifluoromethylpyridineRelated Search:

Azamethiphos 3-Trifluoromethylpyridine Trifluoromethanesulfonic anhydride 2-Fluoro-5-trifluoromethylpyridine 2-(Trifluoromethyl)pyridine 4-Methylpyridine 2-Fluoro-3-methylpyridine 2-Fluoro-6-trifluoromethylpyridine 4-(Trifluoromethyl)pyridine (Trifluoromethyl)trimethylsilane 2,4,6-Collidine 2-Chloro-5-chloromethylpyridine 3-（trifluoromethyl) Cinnamaldehyde Pyridine 3-(Trifluoromethyl)benzaldehyde Fluorine 5-Chloro-2-fluoro-3-(trifluoromethyl)pyridine 2-Fluoro-3-trifluoromethylpyridine

  • 2-FLUORO-3-(TRIFLUOROMETHYL)PYRIDINE
  • 2-FLUORO-TRIFLUOROMETHYLPYRIDINE
  • -Fluoro-3-(trifluoromethyl)pyridine
  • Pyridine, 2-fluoro-3-(trifluoroMethyl)-
  • alpha,alpha,alpha,2-Tetrafluoro-3-picoline
  • 2-Floro-3-(trifluoroMethyl)pyridine
  • 2-FLUORO-3-(TRIFLUOROMETHOXY)PYRIDINE
  • 2-Fluoro-3-trifluoromethylpyridine ISO 9001：2015 REACH
  • 2-Fluoro-3-trifluoromethylpyridine Chemical Properties
  • 2-Fluoro-3-(trifluoromethyl)pyridine(FTF)
  • 65753-52-8
  • 65753-58-2
  • C6H3NF3I
  • C6H3F4N
  • Fluorine series
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Halides
  • Pyridines
  • Pyridine
  • Building Blocks
  • Fluorinated