2-Amino-6-fluoropyridine
- Product Name
- 2-Amino-6-fluoropyridine
- CAS No.
- 1597-32-6
- Chemical Name
- 2-Amino-6-fluoropyridine
- Synonyms
- 6-Fluoropyridin-2-amine;6-FLUORO-PYRIDIN-2-YLAMINE;EOS-60628;6-Fluoro-2-pyridinamine;2-AMINO-6-FLUOROPYRIDINE;2-Fluoro-6-aminopyridine;2-Pyridinamine, 6-fluoro-;2-AMino-6-fluoropyriMidine;2-Amino-6-fluoropyridine >2-Amino-6-fluoropyridine 98%
- CBNumber
- CB4438746
- Molecular Formula
- C5H5FN2
- Formula Weight
- 112.11
- MOL File
- 1597-32-6.mol
2-Amino-6-fluoropyridine Property
- Melting point:
- 59-61°C
- Boiling point:
- 225.0±20.0 °C(Predicted)
- Density
- 1.257±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 2.26±0.24(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C5H5FN2/c6-4-2-1-3-5(7)8-4/h1-3H,(H2,7,8)
- InChIKey
- UZALKVXCOUSWSL-UHFFFAOYSA-N
- SMILES
- C1(N)=NC(F)=CC=C1
- CAS DataBase Reference
- 1597-32-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 725064
- Product name
- 2-Amino-6-fluoropyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $46.8
- Updated
- 2023/06/20
- Product number
- 725064
- Product name
- 2-Amino-6-fluoropyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $173
- Updated
- 2023/06/20
- Product number
- A2879
- Product name
- 2-Amino-6-fluoropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $50
- Updated
- 2025/07/31
- Product number
- A2879
- Product name
- 2-Amino-6-fluoropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $151
- Updated
- 2025/07/31
- Product number
- F596293
- Product name
- 6-Fluoropyridin-2-amine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
2-Amino-6-fluoropyridine Chemical Properties,Usage,Production
Description
2-Amino-6-fluoropyridine is an organic intermediate that can be prepared via the nucleophilic substitution reaction of 2,6-difluoropyridine with ammonia.
Uses
2-Amino-6-fluoropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Synthesis
1513-65-1
1597-32-6
The general procedure for the synthesis of 2-amino-6-fluoropyridine from 2,6-difluoropyridine was as follows: 2,6-difluoropyridine (50 g, 434 mmol) was dissolved in ammonium hydroxide solution (200 mL, 28.0-30.0%) in a steel tube and the reaction was heated for 15 hr at 105 °C. Upon completion of the reaction, the mixture was cooled in an ice bath and the precipitate was subsequently collected by filtration. The precipitate was washed with cold water and dried to give 6-fluoro-2-pyridinamine (45.8 g, 94% yield) as a white solid. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 7.53 (m, 1H), 6.36 (dd, 1H), 6.26 (dd, 1H), 4.56 (s, 2H).
References
[1] Patent: WO2006/76131, 2006, A2. Location in patent: Page/Page column 39-40
[2] Patent: WO2007/27999, 2007, A2. Location in patent: Page/Page column 35
[3] Patent: WO2006/36816, 2006, A2. Location in patent: Page/Page column 59-60
[4] Patent: WO2006/26703, 2006, A2. Location in patent: Page/Page column 64-65
[5] Patent: WO2007/87549, 2007, A2. Location in patent: Page/Page column 44; 59
2-Amino-6-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-6-fluoropyridine manufacturers
- Product
- 2-Amino-6-fluoropyridine 1597-32-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 2-Amino-6-fluoropyridine 1597-32-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09