2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE
- Product Name
- 2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE
- CAS No.
- 72587-15-6
- Chemical Name
- 2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE
- Synonyms
- 2-chloro-5-(trifluoroMethyl)-3-nitropyridine;2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 2-chloro-3-nitro-5-(trifluoromethyl)-;2-Chloro-3-nitro-5-(trifluoromethyl)pyridine >6-Chloro-5-nitro-alpha,alpha,alpha-trifluoro-3-picoline;2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB11253440
- Molecular Formula
- C6H2ClF3N2O2
- Formula Weight
- 226.54
- MOL File
- 72587-15-6.mol
2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE Property
- Boiling point:
- 242.3±35.0 °C(Predicted)
- Density
- 1.618±0.06 g/cm3(Predicted)
- refractive index
- 1.4870 to 1.4910
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -5.31±0.10(Predicted)
- form
- Liquid
- color
- Colorless to pale yellow
- CAS DataBase Reference
- 72587-15-6
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C3089
- Product name
- 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $60
- Updated
- 2025/07/31
- Product number
- C3089
- Product name
- 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $240
- Updated
- 2025/07/31
- Product number
- C612975
- Product name
- 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C612975
- Product name
- 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine
- Packaging
- 10g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- PC10641
- Product name
- 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 25g
- Price
- $340
- Updated
- 2021/12/16
2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production
Uses
2-Chloro-3-nitro-5-(trifluoromethyl)pyridine is a synthetic pyridine analogue with a molecular structure containing an active substitutable gene chlorine atom and nitro and trifluoromethyl groups. It is used as a key intermediate in pharmaceutical synthesis.
Synthesis
33252-64-1
72587-15-6
General steps for the synthesis of 5-(trifluoromethyl)-3-nitro-2-chloropyridine from 2-hydroxy-3-nitro-5-trifluoromethylpyridine: (2) 52 g of 2-hydroxy-3-nitro-5-trifluoromethylpyridine was added to 150 mL of phosphorochloridic acid chloride, and 21 g of quinoline was slowly added under stirring, and the rate of addition was controlled so that the internal temperature of the reaction system did not exceed 50 °C, while the 2-hydroxy-3-nitro-5-trifluoromethylpyridine gradually dissolved. 3-nitro-5-trifluoromethylpyridine was gradually dissolved. Under the protection of argon gas, the reaction system was heated by an oil bath and the external temperature was set to 120°C. After the reaction system started to reflux for 20-30 min, the system was kept micro-boiling for 1.5 h. The reaction process was monitored by TLC. The progress of the reaction was monitored by TLC to show that the feedstock was fully reacted and then the heating was stopped and the trichlorophosphorus was concentrated under reduced pressure to remove the trichlorophosphorus. The residue was dissolved in 400 mL of ethyl acetate and washed with 2N HCl (200 mL x 2) to remove quinoline. The mixture was subsequently washed with saturated sodium bicarbonate solution to neutral and the organic phase was dried to give 5-(trifluoromethyl)-3-nitro-2-chloropyridine.TLC conditions: raw material Rf = 0.1, product Rf = 0.7, and the ratio of unfolding agent was petroleum ether/ethyl acetate = 15/1. 50 g of a brown oily product was finally obtained in 88% yield.
References
[1] Patent: CN105111209, 2017, B. Location in patent: Paragraph 0029; 0037
[2] Patent: WO2009/7418, 2009, A1. Location in patent: Page/Page column 23
[3] Patent: WO2005/97805, 2005, A1. Location in patent: Page/Page column 61-62
[4] Tetrahedron, 2014, vol. 70, # 5, p. 1077 - 1083
[5] Journal of Heterocyclic Chemistry, 1996, vol. 33, # 2, p. 287 - 293
2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE manufacturers
- Product
- 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine 72587-15-6
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE 72587-15-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-23
- Product
- 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine 72587-15-6
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-12