5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE

Product Name: 5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE
CAS No.: 111205-55-1
Chemical Name: 5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE
Synonyms: CGS 20625;5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE;2-(4-Methoxyphenyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one;Cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one,5,6,7,8,9,10-hexahydro-2-(4-methoxyphenyl)-
CBNumber: CB7838783
Molecular Formula: C18H19N3O2
Formula Weight: 309.36
MOL File: 111205-55-1.mol

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5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE Property

Boiling point:: 463.6±55.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: <30.94mg/ml in DMSO; <7.73mg/ml in ethanol
pka: 9.27±0.20(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2467
Product name: CGS20625
Purity: ≥99%(HPLC)
Packaging: 10
Price: $180
Updated: 2021/12/16

Tocris

Product number: 2467
Product name: CGS20625
Purity: ≥99%(HPLC)
Packaging: 50
Price: $738
Updated: 2021/12/16

TRC

Product number: C291823
Product name: CGS20625
Packaging: 1mg
Price: $110
Updated: 2021/12/16

TRC

Product number: C291823
Product name: CGS20625
Packaging: 5mg
Price: $415
Updated: 2021/12/16

Usbiological

Product number: 254950
Product name: CGS 20625
Packaging: 10mg
Price: $466
Updated: 2021/12/16

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5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE Chemical Properties,Usage,Production

Uses

CGS 20625 is a potent, selective and orally active partial agonist for the central benzodiazepine receptor. CGS 20625 inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors with an IC50 of 1.3 nM. CGS 20625 can be used for the research of pentylenetetrazol-induced seizures[1].

Definition

ChEBI: LSM-3520 is a member of pyrazoles and a ring assembly.

Biological Activity

Selective, partial agonist for the benzodiazepine binding site of the GABA A receptor. Potently inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors (IC 50 = 1.3 nM) and displays weak affinity for peripheral benzodiazepine (IC 50 = 0.68 - 2.25 μ M) and GABA binding sites (IC 50 > 10000 μ M). Displays anxiolytic activity in vivo following oral administration.

References

[1] Williams M, et al. CGS 20625, a novel pyrazolopyridine anxiolytic. J Pharmacol Exp Ther. 1989 Jan;248(1):89-96. PMID:2563294

5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE Suppliers

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111205-55-1, 5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONERelated Search:

5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE

CGS 20625

Cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one,5,6,7,8,9,10-hexahydro-2-(4-methoxyphenyl)-

2-(4-Methoxyphenyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one

111205-55-1