ChemicalBook > CAS DataBase List > 5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE
5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE
- Product Name
- 5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE
- CAS No.
- 111205-55-1
- Chemical Name
- 5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE
- Synonyms
- CGS 20625;5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE;2-(4-Methoxyphenyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one;Cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one,5,6,7,8,9,10-hexahydro-2-(4-methoxyphenyl)-
- CBNumber
- CB7838783
- Molecular Formula
- C18H19N3O2
- Formula Weight
- 309.36
- MOL File
- 111205-55-1.mol
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5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE Property
- Boiling point:
- 463.6±55.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- <30.94mg/ml in DMSO; <7.73mg/ml in ethanol
- pka
- 9.27±0.20(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
Tocris
- Product number
- 2467
- Product name
- CGS20625
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $180
- Updated
- 2021/12/16
Tocris
- Product number
- 2467
- Product name
- CGS20625
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $738
- Updated
- 2021/12/16
TRC
- Product number
- C291823
- Product name
- CGS20625
- Packaging
- 1mg
- Price
- $110
- Updated
- 2021/12/16
TRC
- Product number
- C291823
- Product name
- CGS20625
- Packaging
- 5mg
- Price
- $415
- Updated
- 2021/12/16
Usbiological
- Product number
- 254950
- Product name
- CGS 20625
- Packaging
- 10mg
- Price
- $466
- Updated
- 2021/12/16
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5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE Chemical Properties,Usage,Production
Uses
CGS 20625 is a potent, selective and orally active partial agonist for the central benzodiazepine receptor. CGS 20625 inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors with an IC50 of 1.3 nM. CGS 20625 can be used for the research of pentylenetetrazol-induced seizures[1].
Definition
ChEBI: LSM-3520 is a member of pyrazoles and a ring assembly.
Biological Activity
Selective, partial agonist for the benzodiazepine binding site of the GABA A receptor. Potently inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors (IC 50 = 1.3 nM) and displays weak affinity for peripheral benzodiazepine (IC 50 = 0.68 - 2.25 μ M) and GABA binding sites (IC 50 > 10000 μ M). Displays anxiolytic activity in vivo following oral administration.
References
[1] Williams M, et al. CGS 20625, a novel pyrazolopyridine anxiolytic. J Pharmacol Exp Ther. 1989 Jan;248(1):89-96. PMID:2563294
5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE Suppliers
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