Thailanstatin D

Product Name: Thailanstatin D
CAS No.: 1609105-89-6
Chemical Name: Thailanstatin D
Synonyms: Thailanstatin D;2-[(3S,5S,7S)-7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[(2Z,4S)-4-(acetyloxy)pent-2-enamido]-3,6-dimethyloxan-2-yl]-3-methylpenta-1,3-dien-1-yl]-1,6-dioxaspiro[2.5]octan-5-yl]acetic acid;1,6-Dioxaspiro[2.5]octane-5-acetic acid, 7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(2Z,4S)-4-(acetyloxy)-1-oxo-2-penten-1-yl]amino]tetrahydro-3,6-dimethyl-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl]-, (3S,5S,7S)-
CBNumber: CB78394258
Molecular Formula: C28H41NO8
Formula Weight: 519.63
MOL File: 1609105-89-6.mol

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Thailanstatin D Property

Boiling point:: 722.3±60.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
pka: 4.37±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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Thailanstatin D Chemical Properties,Usage,Production

Uses

Thailanstatin D, an analogue of Thailanstatin A, is able to inhibit AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis[1].

in vivo

Thailanstatin D (300 μg/kg; ALZET osmotic pumps; daily for 4 days) significantly inhibits the tumor growth^[1].

Animal Model:	NOD-SCID mice ( Mice bearing 22RV1 xenografts)^[1]
Dosage:	300 μg/kg
Administration:	ALZET osmotic pumps; daily for 4 days
Result:	Significantly inhibited the tumor growth.

References

[1] Wang B, et al. Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer. Int J Cancer. 2017;141(10):2121-2130. DOI:10.1002/ijc.30893

Thailanstatin D Preparation Products And Raw materials

Raw materials

Preparation Products

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Thailanstatin D Suppliers

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1609105-89-6, Thailanstatin DRelated Search:

Thailanstatin B Thailanstatin C Thailanstatin A

Thailanstatin D

1,6-Dioxaspiro[2.5]octane-5-acetic acid, 7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(2Z,4S)-4-(acetyloxy)-1-oxo-2-penten-1-yl]amino]tetrahydro-3,6-dimethyl-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl]-, (3S,5S,7S)-

2-[(3S,5S,7S)-7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[(2Z,4S)-4-(acetyloxy)pent-2-enamido]-3,6-dimethyloxan-2-yl]-3-methylpenta-1,3-dien-1-yl]-1,6-dioxaspiro[2.5]octan-5-yl]acetic acid

1609105-89-6

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