SR 11302
- Product Name
- SR 11302
- CAS No.
- 160162-42-5
- Chemical Name
- SR 11302
- Synonyms
- SR 11302;RQANARBNMTXCDM-DKOHIBGUSA-N;(2E,4E,6Z,8E)-3-Methyl-7-(p-tolyl)-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid;(E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoicacid;2,4,6,8-Nonatetraenoic acid, 3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (2E,4E,6Z,8E)-;acid,SR11302,retinoid,SR-11302,Lung,RARE,Cancer,response,Inhibitor,protein-1,SR 11302,inhibit,AP-1,retinoic,element,activator
- CBNumber
- CB7844692
- Molecular Formula
- C26H32O2
- Formula Weight
- 376.53
- MOL File
- 160162-42-5.mol
SR 11302 Property
- Boiling point:
- 541.6±30.0 °C(Predicted)
- Density
- 1.048±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 4.67±0.33(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 16338
- Product name
- SR 11302
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 16338
- Product name
- SR 11302
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 16338
- Product name
- SR 11302
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $235
- Updated
- 2024/03/01
- Product number
- 16338
- Product name
- SR 11302
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $479
- Updated
- 2024/03/01
- Product number
- 2476
- Product name
- SR11302
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $231
- Updated
- 2021/12/16
SR 11302 Chemical Properties,Usage,Production
Description
The receptors for retinoids, RARs and RXRs, induce transcriptional activation by binding the specific retinoid response elements, RARE and RXRE. Alternatively, retinoid receptors interact with and modulate other transcription factors, including activator protein-1 (AP-1). SR 11302 is a synthetic retinoid that inhibits AP-1 activity without activating transcription through RARE. It significantly suppresses both AP-1 activation and phorbol ester-induced papilloma formation in mice when applied topically (0.1 μM). SR 11302 is used to elucidate the role of AP-1 in various signaling pathways.
Uses
SR 11302 is an inhibitor of activator protein-1.
Biological Activity
Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo . Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC 50 > 1 μ M for RAR α , RAR β , RAR γ and RXR α ).
storage
Store at -20°C
SR 11302 Preparation Products And Raw materials
Raw materials
Preparation Products
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