ChemicalBook > CAS DataBase List > SR 11302

SR 11302

Product Name
SR 11302
CAS No.
160162-42-5
Chemical Name
SR 11302
Synonyms
SR 11302;RQANARBNMTXCDM-DKOHIBGUSA-N;(2E,4E,6Z,8E)-3-Methyl-7-(p-tolyl)-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid;(E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoicacid;2,4,6,8-Nonatetraenoic acid, 3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (2E,4E,6Z,8E)-;acid,SR11302,retinoid,SR-11302,Lung,RARE,Cancer,response,Inhibitor,protein-1,SR 11302,inhibit,AP-1,retinoic,element,activator
CBNumber
CB7844692
Molecular Formula
C26H32O2
Formula Weight
376.53
MOL File
160162-42-5.mol
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SR 11302 Property

Boiling point:
541.6±30.0 °C(Predicted)
Density 
1.048±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
crystalline solid
pka
4.67±0.33(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16338
Product name
SR 11302
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
16338
Product name
SR 11302
Purity
≥95%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
16338
Product name
SR 11302
Purity
≥95%
Packaging
10mg
Price
$235
Updated
2024/03/01
Cayman Chemical
Product number
16338
Product name
SR 11302
Purity
≥95%
Packaging
25mg
Price
$479
Updated
2024/03/01
Tocris
Product number
2476
Product name
SR11302
Purity
≥98%(HPLC)
Packaging
10
Price
$231
Updated
2021/12/16
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SR 11302 Chemical Properties,Usage,Production

Description

The receptors for retinoids, RARs and RXRs, induce transcriptional activation by binding the specific retinoid response elements, RARE and RXRE. Alternatively, retinoid receptors interact with and modulate other transcription factors, including activator protein-1 (AP-1). SR 11302 is a synthetic retinoid that inhibits AP-1 activity without activating transcription through RARE. It significantly suppresses both AP-1 activation and phorbol ester-induced papilloma formation in mice when applied topically (0.1 μM). SR 11302 is used to elucidate the role of AP-1 in various signaling pathways.

Uses

SR 11302 is an inhibitor of activator protein-1.

Biological Activity

Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo . Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC 50 > 1 μ M for RAR α , RAR β , RAR γ and RXR α ).

storage

Store at -20°C

SR 11302 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR 11302 Suppliers

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3B Pharmachem (Wuhan) International Co.,Ltd.
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160162-42-5, SR 11302Related Search:

Retinal SR 11302 Retinoic acid Vitamin A

  • SR 11302
  • (E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoicacid
  • RQANARBNMTXCDM-DKOHIBGUSA-N
  • 2,4,6,8-Nonatetraenoic acid, 3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (2E,4E,6Z,8E)-
  • (2E,4E,6Z,8E)-3-Methyl-7-(p-tolyl)-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
  • acid,SR11302,retinoid,SR-11302,Lung,RARE,Cancer,response,Inhibitor,protein-1,SR 11302,inhibit,AP-1,retinoic,element,activator
  • 160162-42-5