Taurolidine

Product Name: Taurolidine
CAS No.: 19388-87-5
Chemical Name: Taurolidine
Synonyms: Taurolidin;TauroL;taurolin;Tauroline;TAUROLIDINE;Taurolidine USP/EP/BP;CAS19388-87-5 Taurolidine;Benzaldehyde,3,4-dichloro-3-hydroxy-;4,4'-methylenebis(1,2,4-thiadiazinane1,1-dioxide);4,4'-Methylenebis(1,2,4-thiadiazinane 1,1-dioxide)
CBNumber: CB7845341
Molecular Formula: C7H16N4O4S2
Formula Weight: 284.36
MOL File: 19388-87-5.mol

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Taurolidine Property

Melting point:: 154-158°
Boiling point:: 471.2±55.0 °C(Predicted)
Density: 1.466±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO: >20mg/mL
form: powder
pka: 11.16±0.20(Predicted)
color: white to off-white
Stability:: Unstable in Aqueous Solution

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T7329
Product name: Taurolidine
Purity: >97% (NMR), powder
Packaging: 5mg
Price: $147
Updated: 2024/03/01

Sigma-Aldrich

Product number: T7329
Product name: Taurolidine
Purity: >97% (NMR), powder
Packaging: 25mg
Price: $546
Updated: 2024/03/01

Cayman Chemical

Product number: 15374
Product name: Taurolidine
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 15374
Product name: Taurolidine
Purity: ≥98%
Packaging: 10mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 15374
Product name: Taurolidine
Purity: ≥98%
Packaging: 25mg
Price: $116
Updated: 2024/03/01

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Taurolidine Chemical Properties,Usage,Production

Uses

Taurolidine is a derivative of the amino acid Taurine (T007850). Taurolidine exhibits antiendotoxin and antimicrobial activity, and has also been shown to exhibit antitumour activity in vitro and in vivo. Taurolidine is used for the treatment of sepsis and is utilized in hospitals to prevent catheter-related bloodstream infections.

Definition

ChEBI: Taurolidine is a thiadiazinane.

Biological Activity

taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions.taurine, a conditionally-essential amino acid, is not utilized in protein synthesis, but is found free or in simple peptides. taurine has been shown to be essential in mammalian development. in vitro studies have demonstrated that low levels of taurine are associated with various pathological lesions.

in vitro

previous study found that in selected human and murine tumor cell lines, a 3-day exposure to taurolidine could inhibit the growth of all of the cell lines. further mechanistic study showed that in nih-3t3 murine fibroblasts and the pa-1 and skov-3 human ovarian tumor cells, a 48-h exposure to taurolidine had little effect on cell cycle distribution in pa-1 and skov-3 cells but greatly increased the appearance of dna debris, an effect consistent with an induction of apoptosis. in contrast, in nih-3t3 cells, taurolidine exposure did not increase dna debris in the sub-g(0)/g(1) region [1].

in vivo

animal study found that the i.v. administration of 2% taurolidine and 3% taurolidine as well the i.p. application of 2% taurolidine could decrease the development of advanced i.p. tumor lesions. no changes of differential blood count nor relevant animal weight changes resulted. moreover, taurolidine did not impair the liver tissue, kidneys, svc, and leucopoiesis. the intravenous therapy of 2% taurolidine was found to be safe and anti-tumorigenic in advanced local tumor growth in rats [2].

IC 50

9.6-34.2 microm for several cancer cell lines

References

[1] calabresi, p. ,goulette, f.a. and darnowski, j.w. taurolidine: cytotoxic and mechanistic evaluation of a novel antineoplastic agent. cancer research 61(18), 6816-6821 (2001).
[2] braumann c, stuhldreier b, bobrich e, menenakos c, rogalla s, jacobi ca. high doses of taurolidine inhibit advanced intraperitoneal tumor growth in rats. j surg res. 2005 nov;129(1):129-35.

Taurolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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Taurolidine Suppliers

China 140 Europe 2 Germany 1 India 3 United Kingdom 2 United States 18 Global 166

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Aladdin Scientific

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View Lastest Price from Taurolidine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Taurolidine 19388-87-5
Price: US $0.00-0.00/Kg/Drum
Min. Order: 100KG
Purity: 99%-101%
Supply Ability: 1000KG
Release date: 2021-06-08

Baoji Guokang Bio-Technology Co., Ltd.

Product: Taurolidine 19388-87-5
Price: US $27788.00/KG
Min. Order: 25KG
Purity: 99%
Supply Ability: 5t
Release date: 2021-06-07

Chengdu Aupone Pharmaceutical Co.Ltd.

Product: Taurolidine 19388-87-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.99
Supply Ability: 10Tons
Release date: 2024-08-30

19388-87-5, TaurolidineRelated Search:

Sodium taurocholate Hydrochlorothiazide Tauroursodeoxycholic acid Amprolium Tolterodine acetomycin Streptomycin sulfate geninthiocin (S)-(+)-Ascochin Kanamycin sulfate Clindamycin hydrochloride Cefotaxime sodium MALFORMINC Taurultam 2-AMINO-ETHANESULFONAMIDE 2-AMINO-N-METHYLETHANESULFONAMIDE Taurolidine

taurolin

TAUROLIDINE

2H-1,2,4-Thiadiazine, 4,4'-methylenebis[tetrahydro-, 1,1,1',1'-tetraoxide

4,4'-Methylenebis(perhydro-1,2,4-thiadiazin 1,1-dioxide)

4-[(1,1-Dioxo-1,2,4-thiadiazinan-4-yl)methyl]-1,2,4-thiadiazinane 1,1-dioxide

4,4'-Methylenebis(tetrahydro-2H-1,2,4-thiadiazine 1,1-dioxide)

Tauroline

4,4'-methylenebis[tetrahydro-2h-1,2,4-thiadiazine] 1,1,1',1'-tetraoxide

Taurolidin

TauroL

Taurolidine USP/EP/BP

CAS19388-87-5 Taurolidine

4,4'-Methylenebis(1,2,4-thiadiazinane 1,1-dioxide)

Benzaldehyde,3,4-dichloro-3-hydroxy-

4,4'-methylenebis(1,2,4-thiadiazinane1,1-dioxide)

19388-87-5

C7H16N4O4S2