4-CHLORO-7-NITROQUINAZOLINE
- Product Name
- 4-CHLORO-7-NITROQUINAZOLINE
- CAS No.
- 19815-17-9
- Chemical Name
- 4-CHLORO-7-NITROQUINAZOLINE
- Synonyms
- 103281;AKOS 91177;4-CHLORO-7-NITROQUINAZOLINE;Quinazoline, 4-chloro-7-nitro-;4-Chloro-7-nitro-quinazoline, 95+%
- CBNumber
- CB7846676
- Molecular Formula
- C8H4ClN3O2
- Formula Weight
- 209.59
- MOL File
- 19815-17-9.mol
4-CHLORO-7-NITROQUINAZOLINE Property
- Melting point:
- 146-147℃
- Boiling point:
- 380.0±22.0 °C(Predicted)
- Density
- 1.566
- storage temp.
- -20°C, sealed storage, away from moisture
- pka
- -0.33±0.70(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FC10267
- Product name
- 4-Chloro-7-nitroquinazoline
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC10267
- Product name
- 4-Chloro-7-nitroquinazoline
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC10267
- Product name
- 4-Chloro-7-nitroquinazoline
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 126438
- Product name
- 4-Chloro-7-nitroquinazoline
- Purity
- >95%
- Packaging
- 1g
- Price
- $198
- Updated
- 2021/12/16
- Product number
- HCH0106053
- Product name
- 4-CHLORO-7-NITROQUINAZOLINE
- Purity
- 98.00%
- Packaging
- 1G
- Price
- $237.84
- Updated
- 2021/12/16
4-CHLORO-7-NITROQUINAZOLINE Chemical Properties,Usage,Production
Synthesis
20872-93-9
19815-17-9
General procedure for the synthesis of 4-chloro-7-nitroquinazoline from 7-nitroquinazolin-4(3H)-one: 7-nitroquinazolin-4(3H)-one (20.93 mmol) was suspended in 35 mL of thionyl chloride with catalytic amount of DMF (3 drops). The reaction mixture was refluxed at 110 °C for about 3 h until the solution became clear. Upon completion of the reaction, the excess thionyl chloride was removed by distillation under reduced pressure. Subsequently, anhydrous benzene was added to the residue and distilled again under reduced pressure to completely remove the residual thionyl chloride. The crude product obtained was dissolved in dichloromethane (CH2Cl2) and the pH was carefully adjusted to 7-8 with sodium carbonate (Na2CO3) solution.The reaction mixture was extracted with dichloromethane (CH2Cl2) and the organic phase was dried with anhydrous sodium sulfate (Na2SO4). Finally, the solvent was removed by concentration under reduced pressure to give the target product 4-chloro-7-nitroquinazoline (3.5 g, 16.74 mmol).
References
[1] Journal of the American Chemical Society, 2016, vol. 138, # 33, p. 10554 - 10560
[2] Patent: US2017/174638, 2017, A1. Location in patent: Paragraph 0045
[3] Spectroscopy Letters, 2012, vol. 45, # 7, p. 530 - 540,11
[4] Patent: US1880447, 1929,
[5] Journal of the Chemical Society, 1948, p. 360,364
4-CHLORO-7-NITROQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLORO-7-NITROQUINAZOLINE manufacturers
- Product
- 4-CHLORO-7-NITROQUINAZOLINE 19815-17-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25