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MRS 2365

Product Name
MRS 2365
CAS No.
436847-09-5
Chemical Name
MRS 2365
Synonyms
MRS 2365;MRS 2365, CID: 73755043;Diphosphoric acid, P-[[(1R,2R,3S,4R,5S)-4-[6-amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] ester;[[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl]diphosphoricacidmonoestertrisodiumsalt;[[(1R,2R,3S,4R,5S)-4-[6-AMINO-2-(METHYLTHIO)-9H-PURIN-9-YL]-2,3-DIHYDROXYBICYCLO[3.1.0]HEX-1-YL]METHYL] DIPHOSPHORIC ACID MONO ESTER TRISODIUM SALT
CBNumber
CB7847532
Molecular Formula
C13H19N5O9P2S
Formula Weight
483.33
MOL File
436847-09-5.mol
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MRS 2365 Property

Boiling point:
875.5±75.0 °C(Predicted)
Density 
2.37±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
pka
1.42±0.10(Predicted)
form 
Powder
Water Solubility 
Soluble in water (supplied pre-dissolved at a concentration of 10mM)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2157
Product name
MRS2365
Purity
≥98%(HPLC)
Packaging
1
Price
$389
Updated
2021/12/16
TRC
Product number
M750253
Product name
MRS2365
Packaging
1mg
Price
$355
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008065
Product name
MRS 2365
Purity
95.00%
Packaging
5MG
Price
$501.99
Updated
2021/12/16
Biosynth Carbosynth
Product number
FM30703
Product name
MRS 2365
Packaging
1mg
Price
$578
Updated
2021/12/16
ApexBio Technology
Product number
B5264
Product name
MRS2365
Packaging
1mg
Price
$581
Updated
2021/12/16
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MRS 2365 Chemical Properties,Usage,Production

Uses

MRS2365 is a potent and selective P2Y1 receptor (EC50=0.4 nM) /[35S]GTPγS binding/β-arrestin 2 recruitment agonist with an EC50 of 0.4 nM. MRS2365 relieves mechanical allodynia and increases mechanical sensitivity. MRS2365 shows little agonist or antagonist activity at the P2Y12 or P2Y13 receptors[1][2][3][4].

Biological Activity

Highly potent, selective P2Y 1 receptor agonist (EC 50 = 0.4 nM). Displays no activity at P2Y 12 receptors and only very low agonist activity at P2Y 13 receptors (at concentrations up to 1 μ M).

in vivo

MRS2365 (0.03-0.3 mg/kg; i.p.; single dose) significantly alleviates the mechanical allodynia in the male wistar rats neuropathy (Seltzer) model with dose-dependent manner[3].
MRS2365 (0.1-2 mg/kg; i.p.; single dose) increases the paw withdrawal threshold (PWT) in male wistar rats with neuropathic pain model[3].

Animal Model:Male Wistar rats with neuropathic pain(250-350 g)[3].
Dosage:0.03, 0.1, 0.3, 1 and 2 mg/kg.
Administration:Intraperitoneal injection; single dose.
Result:Relieved mechanical allodynia and increased the paw withdrawal threshold.

IC 50

P2Y1 Receptor: 0.4 nM (EC50)

References

[1] Mariya Chhatriwala, et al. Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43. DOI:10.1124/jpet.104.068650
[2] D M Bourdon, et al. (N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets. J Thromb Haemost. 2006 Apr;4(4):861-8. DOI:10.1111/j.1538-7836.2006.01866.x
[3] Andó RD, et al. A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain. Br J Pharmacol. 2010 Mar;159(5):1106-17. DOI:10.1111/j.1476-5381.2009.00596.x
[4] Gao ZG, et al. Distinct Signaling Patterns of Allosteric Antagonism at the P2Y1 Receptor. Mol Pharmacol. 2017 Nov;92(5):613-626. DOI:10.1124/mol.117.109660

MRS 2365 Preparation Products And Raw materials

Raw materials

Preparation Products

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MRS 2365 Suppliers

China 19 Germany 1 United Kingdom 2 United States 3 Global 25
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
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China
ProdList
15838
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69
Jinan Yaoyan Pharmaceutical Co., Ltd.
Tel
Fax
-
Email
jnyaoyan@163.com
Country
China
ProdList
3069
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58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
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58
JinOu Biomedical (Nanjing) Co., Ltd.
Tel
13000000000
Fax
jinoupharma@163
Email
jinoupharma@163.com
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China
ProdList
11721
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Shanghai Universal Biotech Co.,Ltd
Tel
15921930842 15921930842
Email
yh-wang@univ-bio.com
Country
China
ProdList
25004
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58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
29423
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R&D Systems, Inc
Tel
18003437475
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1-612-656-4400
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rdname@qq.com
Country
China
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6960
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Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
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Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel
+86-057181025280; +8617767106207
Fax
0571-85806285
Email
sales@molcore.com
Country
China
ProdList
49734
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Guangzhou Ruifeng Biotechnology Co., Ltd.
Tel
14715141318
Country
CHINA
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181
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Biorbyt Ltd.
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info@biorbyt.com
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CHINA
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Beijing Taize Jiaye Technology Development Co., Ltd.
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6050
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Shanghai Chaoyan Biotechnology Co., Ltd.
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CHINA
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Beijing Bolide Biotechnology Co., Ltd.
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Shanghai Yuda Industrial Co., Ltd.
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Shanghai Haoyang Biological Technology Co., Ltd.
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Beijing Fubo Biotechnology Co., Ltd.
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Shanghai Weiwei Biological Technology Co., Ltd.
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sales@wheybio.com
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CHINA
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Xiamen Huijia Biological Technology Co., Ltd.
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436847-09-5, MRS 2365Related Search:

ARISTEROMYCIN cis-2-ethylcyclopropanemethanol 2-MERCAPTOPURINE 9-cyclohexyladenine 9-CYCLOPENTYLADENINE MRS 2365 1,1-Bis(hydroxymethyl)cyclopropane

  • MRS 2365
  • [[(1R,2R,3S,4R,5S)-4-[6-AMINO-2-(METHYLTHIO)-9H-PURIN-9-YL]-2,3-DIHYDROXYBICYCLO[3.1.0]HEX-1-YL]METHYL] DIPHOSPHORIC ACID MONO ESTER TRISODIUM SALT
  • [[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl]diphosphoricacidmonoestertrisodiumsalt
  • MRS 2365, CID: 73755043
  • Diphosphoric acid, P-[[(1R,2R,3S,4R,5S)-4-[6-amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] ester
  • 436847-09-5
  • C13H16N5O9P2SNa3
  • C13H19N5O9P2S