(R)-(-)-2-Amino-1-propanol
- Product Name
- (R)-(-)-2-Amino-1-propanol
- CAS No.
- 35320-23-1
- Chemical Name
- (R)-(-)-2-Amino-1-propanol
- Synonyms
- (R)-1-Aminopropan-2-ol;D-ALANINOL;(R)-2-AMINO-1-PROPANOL;(2R)-2-AMINO-1-PROPANOL;D-ALAOH;2-AMINO PROPANOL;(2R)-2-Aminopropan-1-ol;D-Ala-ol;D-Alaniol;H-D-ALA-OL
- CBNumber
- CB7853542
- Molecular Formula
- C3H9NO
- Formula Weight
- 75.11
- MOL File
- 35320-23-1.mol
(R)-(-)-2-Amino-1-propanol Property
- Melting point:
- 8 °C
- Boiling point:
- 173-176 °C(lit.)
- alpha
- -17 º (c=neat)
- Density
- 0.965
- refractive index
- n20/D 1.450(lit.)
- Flash point:
- 183 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Oily Liquid
- pka
- 12.88±0.10(Predicted)
- color
- Clear colorless to light yellow
- Specific Gravity
- 0.965
- optical activity
- [α]19/D 18°, neat
- Water Solubility
- SOLUBLE
- Sensitive
- Hygroscopic
- BRN
- 1718866
- CAS DataBase Reference
- 35320-23-1(CAS DataBase Reference)
- NIST Chemistry Reference
- (R)-(-)-2-Amino-1-propanol(35320-23-1)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34-36/37/38
- Safety Statements
- 26-36/37/39-45-36
- RIDADR
- UN 2735 8/PG 2
- WGK Germany
- 3
- F
- 10-23
- Hazard Note
- Corrosive/Hygroscopic
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29221990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 297682
- Product name
- (R)-(?)-2-Amino-1-propanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $25.92
- Updated
- 2024/03/01
- Product number
- 297682
- Product name
- (R)-(?)-2-Amino-1-propanol
- Purity
- 98%
- Packaging
- 5g
- Price
- $132
- Updated
- 2023/06/20
- Product number
- A2002
- Product name
- (R)-(-)-2-Amino-1-propanol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5mL
- Price
- $86
- Updated
- 2025/07/31
- Product number
- A2002
- Product name
- (R)-(-)-2-Amino-1-propanol
- Purity
- >98.0%(GC)(T)
- Packaging
- 25mL
- Price
- $254
- Updated
- 2025/07/31
- Product number
- A628145
- Product name
- (R)-(-)-2-Amino-1-propanol
- Packaging
- 2.5g
- Price
- $55
- Updated
- 2021/12/16
(R)-(-)-2-Amino-1-propanol Chemical Properties,Usage,Production
Chemical Properties
Colorless to light yellow liqui
Uses
(R)-(-)-2-Amino-1-propanol has been used as a derivatizing agent for gossypol during the analysis of gossypol enantiomers in cottonseed by high-performance liquid chromatography.
Application
R)-(-)-2-Amino-1-propanol is used as a chiral intermediate for the synthesis of pharmaceutical products and agrochemicals. It acts as additives in health care products and animal feed. It is a amino alcohol
obtained by reduction of d-alanine. This compound could be converted into the corresponding nonracemic
adenine derivative (R)-9-(1-Methyl-2-hydroxyethyl)adenine through minor variations on the classic
Montgomery sequence[1].
General Description
(R)-(-)-2-Amino-1-propanol is a chiral secondary amine.
Synthesis
338-69-2
35320-23-1
General procedure for the synthesis of (R)-2-aminopropan-1-ol from D-alanine: The present embodiment relates to the synthesis of a class of intermediates of long-chain ethylpiperazine sulfonamide derivatives, in particular the preparation of (R)-2-aminopropan-1-ol. 150 mL of anhydrous THF and 1.1 g of LiAlH4 (29 mmol) were added to a dry three-necked flask and the reaction system was cooled to 0 °C. Subsequently, 4.9 g of D-alanine (55.0 mmol) was added to the reactor in batches, and the addition process lasted for 30 min. After the addition was completed, stirring was continued at 0 °C for 2 h. Then the temperature was gradually increased to reflux and the reflux reaction was maintained for 16 h. The reaction system was then cooled to 0 °C for 2 h. Upon completion of the reaction, the reaction system was cooled in an ice bath, and 100 mL of ether, 4.5 mL of water, 4.5 mL of 15% NaOH solution, and 12 mL of water were added slowly in sequence to quench the reaction. The reaction mixture was filtered through diatomaceous earth and the filtrate was collected. The filtrate was concentrated under reduced pressure to remove the solvent to give the crude product. The crude product was purified by silica gel column chromatography with the eluent of dichloromethane:ethanol=10:1 (v/v), resulting in 3.41 g of colorless oily product in 82.5% yield.
References
[1] Jeffery A, et al. Synthesis of Acyclic Nucleoside and Nucleotide Analogues from Amino Acids: A Convenient Approach to a PMEA±PMPA Hybrid. Tetrahedron, 2000; 56: 5077-5083.
(R)-(-)-2-Amino-1-propanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-(-)-2-Amino-1-propanol manufacturers
- Product
- (R)-(-)-2-Amino-1-propanol 35320-23-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-27
- Product
- (R)-(-)-2-Amino-1-propanol 35320-23-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 5 MTs
- Release date
- 2024-05-10
- Product
- (R)-2-Aminopropan-1-ol 35320-23-1
- Price
- US $590.00/Kg
- Min. Order
- 0.100Kg
- Purity
- 98
- Supply Ability
- 5000 Kg
- Release date
- 2025-03-06