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Neostigmine Methyl Sulfate

Product Name
Neostigmine Methyl Sulfate
CAS No.
51-60-5
Chemical Name
Neostigmine Methyl Sulfate
Synonyms
NEOSTIGMINE METHYL SULPHATE;neostigmine metilsulfate;hodostin;vagostigmin;NEOSTIGIMINE BROMIDE;3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZAMINIUM BROMIDE;GD-65;ar-32;sb-23;Stiglyn
CBNumber
CB7853724
Molecular Formula
C12H19N2O2.CH3O4S
Formula Weight
334.39
MOL File
51-60-5.mol
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Neostigmine Methyl Sulfate Property

Melting point:
175-177 °C(lit.)
storage temp. 
-20°C
solubility 
H2O: 1 g/mL
form 
powder
color 
white
Water Solubility 
1g/10mL
Merck 
14,6464
CAS DataBase Reference
51-60-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T+
Risk Statements 
28-36/37/38-42/43-26/27/28
Safety Statements 
36-45-36/37/39-28A
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
CY1225000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29242990
Toxicity
LD50 in mice (mg/kg): 0.16 i.v.; 0.42 s.c.; 7.5 orally, (Randall, Lehmann)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N2126
Product name
Neostigmine methyl sulfate
Packaging
1g
Price
$58.2
Updated
2024/03/01
Sigma-Aldrich
Product number
1460000
Product name
Neostigmine methyl sulfate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
N0447
Product name
Neostigmine Methyl Sulfate
Purity
>98.0%(N)
Packaging
5g
Price
$113
Updated
2024/03/01
TCI Chemical
Product number
N0447
Product name
Neostigmine Methyl Sulfate
Purity
>98.0%(N)
Packaging
25g
Price
$410
Updated
2024/03/01
Cayman Chemical
Product number
23501
Product name
Neostigmine (methyl sulfate)
Purity
≥98%
Packaging
500mg
Price
$32
Updated
2024/03/01
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Neostigmine Methyl Sulfate Chemical Properties,Usage,Production

Description

Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; Kd = 260 μM). In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 μg, respectively). Neostigmine (5 μg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block. Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome.

Chemical Properties

Crystalline Solid

Uses

Cholinergic; miotic; antidote (curare)

Definition

ChEBI: Neostigmine methyl sulfate is an arylammonium sulfate salt. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor.

brand name

Prostigmine (ICN).

General Description

Neostigmine methylsulfate,(m-hydroxyphenyl)trimethylammonium methylsulfatedimethylcarbamate or the dimethylcarbamic ester of 3-hydroxyphenyltrimethylammoniummethylsulfate (Prostigminmethylsulfate), is a bitter, odorless, white, crystalline powder.It is very soluble in water and soluble in alcohol. Solutionsare stable and can be sterilized by boiling. The compound istoo hygroscopic for use in a solid form and thus is alwaysused as an injection. Aqueous solutions are neutral to litmus.

Clinical Use

The methylsulfate salt is used postoperatively as a urinarystimulant and in the diagnosis and treatment of myastheniagravis.

Purification Methods

Crystallise the sulfate from EtOH or Me2CO (m 143-144o). Its solubility in H2O is ~10%. [Beilstein 13 III 939.] (It is cholinergic and highly TOXIC.)

Neostigmine Methyl Sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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Neostigmine Methyl Sulfate Suppliers

Shanghai Gukang Biotechnology Co., LTD
Tel
021-34080528 13564510648
Fax
021-54301252
Email
info@kanghaopharm.com
Country
China
ProdList
124
Advantage
58
Wuhan Xinru Chemical Co., Ltd.
Tel
15927387915 15337108568
Email
2769903731@qq.com
Country
China
ProdList
3336
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
Advantage
56
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
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View Lastest Price from Neostigmine Methyl Sulfate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Neostigmine Methyl Sulfate 51-60-5
Price
US $0.00/KG
Min. Order
10g
Purity
99%min
Supply Ability
10kg
Release date
2021-11-18
Dideu Industries Group Limited
Product
Neostigmine Methyl Sulfate 51-60-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-27
Zhuozhou Wenxi import and Export Co., Ltd
Product
Neostigmine Methyl Sulfate 51-60-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

51-60-5, Neostigmine Methyl SulfateRelated Search:


  • A sulfuric acid neostigmine
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  • (3-hydroxyphenyl)trimethylammoniummethylsulfatedimethylcarbamicester
  • (m-hydroxyphenyl)trimethylammoniummethylsulfatedimethylcarbamate
  • PROSTIGMINE
  • NEOSTIGIMINE BROMIDE
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  • 3-[N,N-DIMETHYLCARBAMOYLOXY]-N,N,N-TRIMETHYLANILINIUM METHYL SULFATE
  • (3-HYDROXYPHENYL)TRIMETHYLAMMONIUM BROMIDE DIMETHYL CARBAMATE
  • (3-HYDROXYPHENYL)TRIMETHYLAMMONIUM METHYL SULFATE DIMETHYLCARBAMATE
  • 3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZAMINIUM BROMIDE
  • 3-[([DIMETHYLAMINO]CARBONYL)OXY]-N,N,N-TRIMETHYLBENZAMINIUM METHYL SULFATE
  • 3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZENAMINIUM BROMIDE
  • 3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZENAMINIUM METHYL SULFATE
  • (3-DIMETHYLCARBAMOYLOXYPHENYL)TRIMETHYLAMMONIUM BROMIDE
  • (3-DIMETHYLCARBAMOYLOXYPHENYL)TRIMETHYLAMMONIUM METHYL SULFATE
  • neostigmine metilsulfate
  • Intrastigmina
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  • NEOSTIGMINE METHYL SULPHATE(RG)
  • Ethyl N-[2-[4-(phenoxy)phenoxy]ethyl]carbamate
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  • 3-(dimethylcarbamoxy)phenyltrimethylammoniummethylsulfate
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  • ar-32
  • Benzenaminium,3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-,methylsulfate
  • carbamicacid,n,n-dimethyl-,3-(trimethylammonio)phenylester,methylsulfate
  • carbamicacid,n,n-dimethyl-,3-dimethylaminophenylester,methosulfate
  • dimethyl-carbamicaciesterwith(m-hydroxyphenyl)trimethylammoniummethy
  • dimethylcarbamicesterof3-oxyphenyltrimethylammoniummethylsulfate
  • eustigminmethylsulfate
  • hodostin
  • kirkstigminemethylsulfate
  • leostigminemethylsulfate
  • neoeserinemethylsulfate
  • neostigmeth
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  • neostigminemonomethylsulfate
  • normastigmin
  • philostigminmethylsulfate
  • polstigmine
  • proserin
  • proserinemethylsulfate
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  • prostigminmethylsulfate
  • sb-23
  • stigmanolmethylsulfate
  • stigmosanmethylsulfate
  • synstigmine
  • syntostigmin
  • syntostigmin(injection)
  • syntostigmine
  • tl-1394