Neostigmine Methyl Sulfate
- Product Name
- Neostigmine Methyl Sulfate
- CAS No.
- 51-60-5
- Chemical Name
- Neostigmine Methyl Sulfate
- Synonyms
- NEOSTIGMINE METHYL SULPHATE;neostigmine metilsulfate;hodostin;vagostigmin;NEOSTIGIMINE BROMIDE;3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZAMINIUM BROMIDE;GD-65;ar-32;sb-23;Stiglyn
- CBNumber
- CB7853724
- Molecular Formula
- C12H19N2O2.CH3O4S
- Formula Weight
- 334.39
- MOL File
- 51-60-5.mol
Neostigmine Methyl Sulfate Property
- Melting point:
- 175-177 °C(lit.)
- storage temp.
- -20°C
- solubility
- H2O: 1 g/mL
- form
- powder
- color
- white
- Water Solubility
- 1g/10mL
- Merck
- 14,6464
- CAS DataBase Reference
- 51-60-5(CAS DataBase Reference)
Safety
- Hazard Codes
- T+
- Risk Statements
- 28-36/37/38-42/43-26/27/28
- Safety Statements
- 36-45-36/37/39-28A
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- RTECS
- CY1225000
- HazardClass
- 6.1(a)
- PackingGroup
- II
- HS Code
- 29242990
- Toxicity
- LD50 in mice (mg/kg): 0.16 i.v.; 0.42 s.c.; 7.5 orally, (Randall, Lehmann)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P284Wear respiratory protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- N2126
- Product name
- Neostigmine methyl sulfate
- Packaging
- 1g
- Price
- $58.2
- Updated
- 2024/03/01
- Product number
- 1460000
- Product name
- Neostigmine methyl sulfate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- N0447
- Product name
- Neostigmine Methyl Sulfate
- Purity
- >98.0%(N)
- Packaging
- 5g
- Price
- $113
- Updated
- 2024/03/01
- Product number
- N0447
- Product name
- Neostigmine Methyl Sulfate
- Purity
- >98.0%(N)
- Packaging
- 25g
- Price
- $410
- Updated
- 2024/03/01
- Product number
- 23501
- Product name
- Neostigmine (methyl sulfate)
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $32
- Updated
- 2024/03/01
Neostigmine Methyl Sulfate Chemical Properties,Usage,Production
Description
Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; Kd = 260 μM). In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 μg, respectively). Neostigmine (5 μg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block. Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome.
Chemical Properties
Crystalline Solid
Uses
Cholinergic; miotic; antidote (curare)
Definition
ChEBI: Neostigmine methyl sulfate is an arylammonium sulfate salt. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor.
brand name
Prostigmine (ICN).
General Description
Neostigmine methylsulfate,(m-hydroxyphenyl)trimethylammonium methylsulfatedimethylcarbamate or the dimethylcarbamic ester of 3-hydroxyphenyltrimethylammoniummethylsulfate (Prostigminmethylsulfate), is a bitter, odorless, white, crystalline powder.It is very soluble in water and soluble in alcohol. Solutionsare stable and can be sterilized by boiling. The compound istoo hygroscopic for use in a solid form and thus is alwaysused as an injection. Aqueous solutions are neutral to litmus.
Clinical Use
The methylsulfate salt is used postoperatively as a urinarystimulant and in the diagnosis and treatment of myastheniagravis.
Purification Methods
Crystallise the sulfate from EtOH or Me2CO (m 143-144o). Its solubility in H2O is ~10%. [Beilstein 13 III 939.] (It is cholinergic and highly TOXIC.)
Neostigmine Methyl Sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
Neostigmine Methyl Sulfate Suppliers
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View Lastest Price from Neostigmine Methyl Sulfate manufacturers
- Product
- Neostigmine Methyl Sulfate 51-60-5
- Price
- US $0.00/KG
- Min. Order
- 10g
- Purity
- 99%min
- Supply Ability
- 10kg
- Release date
- 2021-11-18
- Product
- Neostigmine Methyl Sulfate 51-60-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-27
- Product
- Neostigmine Methyl Sulfate 51-60-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10