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Mandelonitrile

Product Name
Mandelonitrile
CAS No.
532-28-5
Chemical Name
Mandelonitrile
Synonyms
MANDELONITRILE;Amygdalonitrile;Mandelonitrile>MANDELONITRILE 98%;-Cyanobenzylalcohol;Mandelonitrile ,95%;Phenylglycolonitrile;phenyl-glycolonitril;Mandelonitrile,>98%,;MANDELIC ACID NITRILE
CBNumber
CB7853744
Molecular Formula
C8H7NO
Formula Weight
133.15
MOL File
532-28-5.mol
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Mandelonitrile Property

Melting point:
-10 °C
Boiling point:
170 °C(lit.)
Density 
1.117 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.530(lit.)
Flash point:
207 °F
storage temp. 
Store below +30°C.
solubility 
alcohol: freely soluble
form 
Liquid
pka
10.50±0.20(Predicted)
color 
Yellow to brown
Sensitive 
Moisture Sensitive
Merck 
14,5719
BRN 
2207122
Dielectric constant
17.0(23℃)
Stability:
Stable, but moisture sensitive. Combustible. Incompatible with strong oxidizing agents.
LogP
0.830 (est)
CAS DataBase Reference
532-28-5(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetonitrile, «alpha»-hydroxy-(532-28-5)
EPA Substance Registry System
Mandelonitrile (532-28-5)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25-41
Safety Statements 
22-26-36/37/39-45-24/25
RIDADR 
UN 3276 6.1/PG 3
WGK Germany 
3
RTECS 
OO8400000
21
TSCA 
Yes
HS Code 
2926 90 70
HazardClass 
6.1
PackingGroup 
III
Toxicity
LD50 orally in Rabbit: 116 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.19016
Product name
DL-Mandelic acid nitrile
Purity
for synthesis
Packaging
100mL
Price
$97.3
Updated
2024/03/01
Sigma-Aldrich
Product number
116025
Product name
Mandelonitrile
Purity
technical grade
Packaging
50g
Price
$40
Updated
2023/06/20
Sigma-Aldrich
Product number
8.19016
Product name
DL-Mandelic acid nitrile
Purity
for synthesis
Packaging
250ML
Price
$222
Updated
2023/01/07
TCI Chemical
Product number
M0566
Product name
Mandelonitrile
Purity
>97.0%(GC)
Packaging
25g
Price
$23
Updated
2024/03/01
TRC
Product number
M162560
Product name
Mandelonitrile
Packaging
10g
Price
$85
Updated
2021/12/16
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Mandelonitrile Chemical Properties,Usage,Production

Chemical Properties

reddish-brown liquid. D,L-Mandelonitrile [532-28-5], benzaldehyde cyanohydrin, a-cyano-a-hydroxymethylbenzene, C6H5 – CH(OH) – CN, Mr 133.15, mp-10℃, d204 1.1165 – 1.120, is miscible with ethanol and diethyl ether, immiscible with water. Mandelonitrile occurs naturally as the bglycoside of gentiobiose (amygdalin). It decomposes on heating into benzaldehyde and hydrogen cyanide. It is produced from benzaldehyde and alkali cyanide in the presence of mineral acid. Mandelonitrile is used as an intermediate in the production of mandelic acid.

Occurrence

Mandelonitrile, is a yellow, oily liquid, insoluble in water, but soluble in alcohol and diethyl ether. Mandelonitrile is a component of the glycoside amygdalin, a precursor of laetrile found in the leaves and seeds on most Prunus species (plum, peach, apricot, etc). In 1832, mandelonitrile was the first cyanohydrin to be synthesized. It is commercially prepared from benzaldehyde and hydrogen cyanide. Mandelonitrile is used by certain insects (tiger beetles, an African millipede) as a defense fluid. After expelling the fluid an enzyme catalyzes the conversion of mandelonitrile to benzaldehyde and HCN, which is usually fatal to the insect’s enemy.

Uses

Mandelonitrile has been used to extract mandeloamide by the nitrilase variants.

Definition

ChEBI: Mandelonitrile is a cyanohydrin that is phenylacetonitrile in which one of the methylene hydrogens is replaced by a hydroxy group.

General Description

Reddish-brown to dark red-brown liquid.

Air & Water Reactions

Mandelonitrile is sensitive to moisture. . Insoluble in water.

Reactivity Profile

Nitriles, such as Mandelonitrile, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Mandelonitrile is combustible.

Safety Profile

Poison by intravenous and subcutaneous routes. Mutation data reported. A severe eye irritant. When heated to decomposition it emits toxic fumes of NOx and CN-. See also NITRILES.

Toxicology

Mandelonitrile is rather toxic with an LD50 value (rat, oral) of 116 mg/kg. This high toxicity may be due to the equilibrium of the cyanohydrin with benzaldehyde and hydrogen cyanide.

Mandelonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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Mandelonitrile Suppliers

TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
Hindusthan Chemicals Company
Tel
--
Fax
--
Country
India
ProdList
11
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
CHEMSWORTH
Tel
--
Fax
--
Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
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View Lastest Price from Mandelonitrile manufacturers

Career Henan Chemical Co
Product
Mandelonitrile 532-28-5
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,50kg
Release date
2020-01-18

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