Etifoxine

Product Name: Etifoxine
CAS No.: 21715-46-8
Chemical Name: Etifoxine
Synonyms: 36-801;Etifoxin;Etifoxine;HOE-36801;HOE-36-801;etafenoxine;Etifoxine (HOE36801);6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine;2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine;6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine
CBNumber: CB7875113
Molecular Formula: C17H17ClN2O
Formula Weight: 300.78
MOL File: 21715-46-8.mol

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Etifoxine Property

Melting point:: 90-92℃
Boiling point:: 421.2±55.0 °C(Predicted)
Density: 1.1716 (rough estimate)
vapor pressure: 0-1Pa at 20-25℃
refractive index: 1.5800 (estimate)
storage temp.: Store at -20°C
solubility: DMSO:60.0(Max Conc. mg/mL);199.47(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);99.74(Max Conc. mM)
DMF:PBS (pH 7.2) (1:8):0.1(Max Conc. mg/mL);0.33(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);66.49(Max Conc. mM)
form: Solid:particulate/powder
pka: 4.89±0.40(Predicted)
color: Light yellow to yellow
LogP: 4.09-4.52 at 21-25℃ and pH7

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Safety

Toxicity: LD50 orally in mice: 12 g/kg (Hoffmann)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H401Toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15999
Product name: Etifoxine
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 15999
Product name: Etifoxine
Purity: ≥98%
Packaging: 10mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 15999
Product name: Etifoxine
Purity: ≥98%
Packaging: 25mg
Price: $296
Updated: 2024/03/01

Cayman Chemical

Product number: 15999
Product name: Etifoxine
Purity: ≥98%
Packaging: 50mg
Price: $546
Updated: 2024/03/01

ChemScene

Product number: CS-1104
Product name: Etifoxine
Purity: 99.87%
Packaging: 100mg
Price: $610
Updated: 2021/12/16

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Etifoxine Chemical Properties,Usage,Production

Originator

Circupon,Troponwerke,W. Germany

Definition

ChEBI: Etifoxine is a benzoxazine.

Manufacturing Process

30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and dissolved while warming. After heating for 1 hour under reflux, the acylation is complete. After concentrating the reaction solution, the product is precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2- (N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water, thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan- 1-one, dissolved in a 10-fold amount of water, are added dropwise at room temperature and hydrogenation is carried out until 1 mol of hydrogen has been taken up. After filtering off the catalyst, a further 3 parts of palladium/charcoal are added and hydrogenation is carried out until a further mol of hydrogen has been taken up. The catalyst is separated off and after removal of the solvent the hydrogenation product is reprecipitated from acetone/petroleum ether and from methanol/ether until it is pure according to thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2- ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.

Therapeutic Function

Tranquilizer

Etifoxine Preparation Products And Raw materials

Raw materials

Preparation Products

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Etifoxine Suppliers

China 60 Europe 1 India 1 South Korea 1 United States 11 Global 74

Haoyuan Chemexpress Co., Ltd.

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MedChemexpress LLC

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AdooQ BioScience, LLC

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LETOPHARM LIMITED

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Chongqing Chemieliva Pharmaceutical Co., Ltd.

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21715-46-8, EtifoxineRelated Search:

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Etifoxine

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Etifoxine (HOE36801)

6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine

21715-46-8