ChemicalBook > CAS DataBase List > Etifoxine

Etifoxine

Product Name
Etifoxine
CAS No.
21715-46-8
Chemical Name
Etifoxine
Synonyms
36-801;Etifoxin;Etifoxine;HOE-36801;HOE-36-801;etafenoxine;Etifoxine (HOE36801);6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine;2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine;6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine
CBNumber
CB7875113
Molecular Formula
C17H17ClN2O
Formula Weight
300.78
MOL File
21715-46-8.mol
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Etifoxine Property

Melting point:
90-92℃
Boiling point:
421.2±55.0 °C(Predicted)
Density 
1.1716 (rough estimate)
vapor pressure 
0-1Pa at 20-25℃
refractive index 
1.5800 (estimate)
storage temp. 
Store at -20°C
solubility 
DMSO:60.0(Max Conc. mg/mL);199.47(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);99.74(Max Conc. mM)
DMF:PBS (pH 7.2) (1:8):0.1(Max Conc. mg/mL);0.33(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);66.49(Max Conc. mM)
form 
Solid:particulate/powder
pka
4.89±0.40(Predicted)
LogP
4.09-4.52 at 21-25℃ and pH7
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Safety

Toxicity
LD50 orally in mice: 12 g/kg (Hoffmann)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H401Toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15999
Product name
Etifoxine
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
15999
Product name
Etifoxine
Purity
≥98%
Packaging
10mg
Price
$129
Updated
2024/03/01
Cayman Chemical
Product number
15999
Product name
Etifoxine
Purity
≥98%
Packaging
25mg
Price
$296
Updated
2024/03/01
Cayman Chemical
Product number
15999
Product name
Etifoxine
Purity
≥98%
Packaging
50mg
Price
$546
Updated
2024/03/01
ChemScene
Product number
CS-1104
Product name
Etifoxine
Purity
99.87%
Packaging
100mg
Price
$610
Updated
2021/12/16
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Etifoxine Chemical Properties,Usage,Production

Originator

Circupon,Troponwerke,W. Germany

Definition

ChEBI: Etifoxine is a benzoxazine.

Manufacturing Process

30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and dissolved while warming. After heating for 1 hour under reflux, the acylation is complete. After concentrating the reaction solution, the product is precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2- (N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water, thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan- 1-one, dissolved in a 10-fold amount of water, are added dropwise at room temperature and hydrogenation is carried out until 1 mol of hydrogen has been taken up. After filtering off the catalyst, a further 3 parts of palladium/charcoal are added and hydrogenation is carried out until a further mol of hydrogen has been taken up. The catalyst is separated off and after removal of the solvent the hydrogenation product is reprecipitated from acetone/petroleum ether and from methanol/ether until it is pure according to thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2- ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.

Therapeutic Function

Tranquilizer

Etifoxine Preparation Products And Raw materials

Raw materials

Preparation Products

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Etifoxine Suppliers

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21715-46-8, EtifoxineRelated Search:

2-amino-5-chloro-diphenyl methanol O-ISOPROPYLISOUREA HYDROCHLORIDE N,N-didemethylchlordimeform O-Ethylisourea hydrochloride demethylchlordimeform O-Methylisourea hydrochloride Etifoxine ISOPROPYL FORMIMIDATE HYDROCHLORIDE 4H-BENZO[D][1,3]OXAZIN-2-AMINE

  • etafenoxine
  • 36-801
  • 6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine
  • Etifoxin
  • HOE-36801
  • HOE-36-801
  • 2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine
  • Etifoxine
  • 4H-3,1-Benzoxazin-2-amine, 6-chloro-N-ethyl-4-methyl-4-phenyl-
  • Etifoxine (HOE36801)
  • 6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine
  • 21715-46-8