lasiocarpine Property

Melting point:

96.5-97.0℃

alpha 

D -4° (10% alc)

Boiling point:

531.2°C (rough estimate)

Density 

1.21±0.1 g/cm3 (20 ºC 760 Torr)

refractive index 

1.5614 (estimate)

pka

11.99±0.29(Predicted)

Water Solubility 

6.754g/L(temperature not stated)

Stability:

Stable, but is readily hydrolyzed in basic solution and readily oxidized by oxidizing agents. Reacts slowly with atmospheric oxygen.

LogP

1.280

IARC

2B (Vol. 10, Sup 7) 1987

EPA Substance Registry System

Lasiocarpine (303-34-4)

Safety

RIDADR 

1544

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

303-34-4(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

lasiocarpine Chemical Properties,Usage,Production

Description

A hepatotoxic alkaloid found in Heliotropiurn lasiocarpurn, the base forms colourless leaflets from petroleum ether and has [α]²⁰_D - 4° (EtOH). It is readily soluble in C6H6 or EtOH but only slightly so in H20. On alkaline hydrolysis it furnishes angelic acid and heliotridine, C8H1302N, m.p. 116.5-118°C, forming a hydrochloride, m.p. 122-4°C and the benzoyl derivative hydrochloride, m.p. 180°C. On catalytic hydrogenation it yields a base, C13H230 2N, b.p. 123-5°Cj 8 mm; [α]_D + 3.8° (EtOH), yielding a crystalline picrate, m.p. 157 _9°C, and lasiocarpic acid, C8H160 S, m.p. 95-7°C; [α]_D + 10.6° (EtOH). The structure is therefore angelyllasiocarpylheliotridine, both hydroxyls in heliotridine being es terifie d

Chemical Properties

colourless to beige crystalline solid

Uses

Lasiocarpine is a hepatotoxic and carcinogenic food contaminant.

General Description

Colorless plates or beige crystalline solid.

Air & Water Reactions

Decomposes slowly on standing in air at room temperature. Insoluble in water.

Reactivity Profile

lasiocarpine is readily hydrolyzed by alkali. Reacts readily with oxidizing agents. Reacts slowly with atmospheric oxygen .

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition lasiocarpine emits toxic fumes of nitrogen oxides.

Fire Hazard

Flash point data for lasiocarpine are not available; however, lasiocarpine is probably combustible.

References

Men'shikov., Ber., 65,974 (1932)