Edatrexate

Product Name: Edatrexate
CAS No.: 80576-83-6
Chemical Name: Edatrexate
Synonyms: EDX;CGP 30694;Edatrexate;NSC 626715;PSYLLIUMSEED;FSIRXIHZBIXHKT-MHTVFEQDSA-N;10-Ethyl-10-deazaaminopterin;10-Ethyl-10-deazaaminopterine;N-[4-[1-[(2,4-Diaminopteridin-6-yl)methyl]propyl]benzoyl]-L-glutamic acid;N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)propyl)benzoyl)-L-glutamic acid
CBNumber: CB7875719
Molecular Formula: C22H25N7O5
Formula Weight: 467.48
MOL File: 80576-83-6.mol

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Edatrexate Property

Density: 1.441±0.06 g/cm3(Predicted)
pka: 3.56±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0005190
Product name: EDATREXATE
Purity: 95.00%
Packaging: 5MG
Price: $503.73
Updated: 2021/12/16

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Edatrexate Chemical Properties,Usage,Production

Uses

Antineoplastic.

Definition

ChEBI: Edatrexate is a glutamic acid derivative.

in vivo

Edatrexate (0.14 g/kg and 0.21 g/kg; i.p.; twice weekly×3 or weekly×3) exerts potent efficacy against advanced metastatic disease in tumor-bearing mice, better than MTX^[1].

Animal Model:	Murine models of advanced metastatic disease (including E0771 mammary adenocarcinoma, T241 fibrosarcoma, Lewis lung carcinoma, B16 melanoma, or C38 colon carcinoma)^[2]
Dosage:	0.14 g/kg and 0.21 g/kg
Administration:	Intraperitoneal injection; 0.14 g/kg twice weekly for 3 weeks and 0.21 g/kg weekly for 3 weeks; added Ca leucovorin (LCV) 16, 20, 24 h after Edatrexate treatment
Result:	Increased survival of tumor-bearing mice. Showed markedly therapeutic effectiveness against advanced metastatic disease in high-dose regimen with delayed LCV rescue.

Edatrexate Preparation Products And Raw materials

Raw materials

Preparation Products

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Edatrexate Suppliers

China 7 Europe 2 India 1 United Kingdom 1 United States 3 Global 14

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

SIMAGCHEM CORP

Tel: +86-5922680277 +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17346
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
Advantage: 58

TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19962
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

80576-83-6, EdatrexateRelated Search:

Methanol Glycine ALTRENOGEST Methyl acrylate Propyl butyrate Methylparaben Lithium diisopropylamide Propyl gallate Benzoyl chloride Benzoyl peroxide Betaine Acetonitrile Glutamic acid (+-) 1-BROMO-2-METHYLBUTANE 95 Methyl 2-BUTYL PYRAZINE 2-ISOBUTYLPYRAZINE Edatrexate

(S)-2-[4-[1-[(2,4-Diaminopteridine-6-yl)methyl]propyl]benzoylamino]pentanedioic acid

10-Ethyl-10-deazaaminopterin

10-Ethyl-10-deazaaminopterine

EDX

N-[4-[1-[(2,4-Diaminopteridin-6-yl)methyl]propyl]benzoyl]-L-glutamic acid

CGP 30694

NSC 626715

FSIRXIHZBIXHKT-MHTVFEQDSA-N

Edatrexate

PSYLLIUMSEED

2-[[4-[1-(2,4-Diaminopteridin-6-yl)butan-2-yl]benzoyl]amino]pentanedioic acid

N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)propyl)benzoyl)-L-glutamic acid

L-Glutamic acid, N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]propyl]benzoyl]-

80576-83-6

C22H25N7O5