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Edatrexate

Product Name
Edatrexate
CAS No.
80576-83-6
Chemical Name
Edatrexate
Synonyms
EDX;CGP 30694;Edatrexate;NSC 626715;PSYLLIUMSEED;FSIRXIHZBIXHKT-MHTVFEQDSA-N;10-Ethyl-10-deazaaminopterin;10-Ethyl-10-deazaaminopterine;N-[4-[1-[(2,4-Diaminopteridin-6-yl)methyl]propyl]benzoyl]-L-glutamic acid;N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)propyl)benzoyl)-L-glutamic acid
CBNumber
CB7875719
Molecular Formula
C22H25N7O5
Formula Weight
467.48
MOL File
80576-83-6.mol
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Edatrexate Property

Density 
1.441±0.06 g/cm3(Predicted)
pka
3.56±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0005190
Product name
EDATREXATE
Purity
95.00%
Packaging
5MG
Price
$503.73
Updated
2021/12/16
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Edatrexate Chemical Properties,Usage,Production

Uses

Antineoplastic.

Definition

ChEBI: Edatrexate is a glutamic acid derivative.

in vivo

Edatrexate (0.14 g/kg and 0.21 g/kg; i.p.; twice weekly×3 or weekly×3) exerts potent efficacy against advanced metastatic disease in tumor-bearing mice, better than MTX[1].

Animal Model:Murine models of advanced metastatic disease (including E0771 mammary adenocarcinoma, T241 fibrosarcoma, Lewis lung carcinoma, B16 melanoma, or C38 colon carcinoma)[2]
Dosage:0.14 g/kg and 0.21 g/kg
Administration:Intraperitoneal injection; 0.14 g/kg twice weekly for 3 weeks and 0.21 g/kg weekly for 3 weeks; added Ca leucovorin (LCV) 16, 20, 24 h after Edatrexate treatment
Result:Increased survival of tumor-bearing mice.
Showed markedly therapeutic effectiveness against advanced metastatic disease in high-dose regimen with delayed LCV rescue.

Edatrexate Preparation Products And Raw materials

Raw materials

Preparation Products

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Edatrexate Suppliers

China 7 Europe 2 India 1 United Kingdom 1 United States 3 Global 14
ecochem international chemical broker
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Fax
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Email
export@ecochem.dk
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Europe
ProdList
6371
Advantage
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kemikalieimport
Tel
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Fax
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Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
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80576-83-6, EdatrexateRelated Search:

Methanol Glycine ALTRENOGEST Methyl acrylate Propyl butyrate Methylparaben Lithium diisopropylamide Propyl gallate Benzoyl chloride Benzoyl peroxide Betaine Acetonitrile Glutamic acid (+-) 1-BROMO-2-METHYLBUTANE 95 Methyl 2-BUTYL PYRAZINE 2-ISOBUTYLPYRAZINE Edatrexate

  • (S)-2-[4-[1-[(2,4-Diaminopteridine-6-yl)methyl]propyl]benzoylamino]pentanedioic acid
  • 10-Ethyl-10-deazaaminopterin
  • 10-Ethyl-10-deazaaminopterine
  • EDX
  • N-[4-[1-[(2,4-Diaminopteridin-6-yl)methyl]propyl]benzoyl]-L-glutamic acid
  • CGP 30694
  • NSC 626715
  • FSIRXIHZBIXHKT-MHTVFEQDSA-N
  • Edatrexate
  • PSYLLIUMSEED
  • 2-[[4-[1-(2,4-Diaminopteridin-6-yl)butan-2-yl]benzoyl]amino]pentanedioic acid
  • N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)propyl)benzoyl)-L-glutamic acid
  • L-Glutamic acid, N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]propyl]benzoyl]-
  • 80576-83-6
  • C22H25N7O5