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butropium bromide

Product Name
butropium bromide
CAS No.
29025-14-7
Chemical Name
butropium bromide
Synonyms
BHB;Coliopan;Butropan;Butropium;[3(S)-endo]-;butropium bromide;butoxybenzyl hyoscyamine;N-(Butoxybenzyl)hyoscyamine bromide;(p-Butoxybenzyl)hyoscyaminium bromide;1αH,5αH-Tropanium, 8-(p-butoxybenzyl)-3α-hydroxy-, bromide, (-)-tropate (8CI)
CBNumber
CB7877900
Molecular Formula
C28H38NO4.Br
Formula Weight
532.515
MOL File
29025-14-7.mol
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butropium bromide Property

Melting point:
166-168oC
alpha 
D20 -21.7° (c = 0.5 in water)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
color 
White to Off-White
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Safety

Toxicity
LD50 in male mice (mg/kg): 1500 orally; 660 s.c.; 12.0 i.v. (Tanaka, Hashimoto, 1972)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B690080
Product name
ButropiumBromide
Packaging
50mg
Price
$1695
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB19431
Product name
Butropium bromide
Packaging
10mg
Price
$1990
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0001796
Product name
BUTROPIUM BROMIDE
Purity
95.00%
Packaging
50MG
Price
$2194.5
Updated
2021/12/16
AK Scientific
Product number
9472CC
Product name
Butropiumbromide
Packaging
10mg
Price
$2736
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0001796
Product name
BUTROPIUM BROMIDE
Purity
95.00%
Packaging
5MG
Price
$816.75
Updated
2021/12/16
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butropium bromide Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Coliopan,Eisai,Japan,1974

Uses

Anticholinergic. Antispasmodic.

Definition

ChEBI: Butropium bromide is an organic bromide salt of butropium. It is a drug which suppresses spasm of smooth muscles of internal organs, inhibits gastric acid secretion and relieves abdominal pain. It is used in the treatment of spasmodic pains associated with gastritis, gastric ulcers and cholelithiasis. It has a role as an antispasmodic drug and a muscarinic antagonist. It is an organic bromide salt and a quaternary ammonium salt. It contains a butropium.

Manufacturing Process

To 100 ml of an isopropanol solution containing 11.8 grams of hyoscyamine base were added drop by drop with stirring 10 ml of an isopropanol solution containing 11 grams of p-n-butoxybenzyl bromide. After a while, the reaction mixture had a turbid appearance followed by separation of white crystals.
After stirring for 5 hours at room temperature, the crystals were recovered by filtration, which were then recrystallized from 120 ml of isopropanol. There was obtained 15.8 grams of white needles having the melting point of 158°- 160°C.

Therapeutic Function

Spasmolytic

butropium bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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butropium bromide Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shaanxi Pioneer Biotech Co., Ltd.
Tel
029-029-86629612 18202932191
Email
sales3@pioneerbiotech.com
Country
China
ProdList
270
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55
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
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58
Shaanxi Pioneer Biotech Co., Ltd .
Tel
+8613259417953
Fax
029-84385017
Email
sales@pioneerbiotech.com
Country
China
ProdList
1287
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
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58
Shaanxi Dideu Newmaterial Co., Ltd.
Tel
029-87576359 15353716720
Email
1039@dideu.com
Country
China
ProdList
10009
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58
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
73043
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Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58

29025-14-7, butropium bromideRelated Search:


  • butropium bromide
  • Butropium
  • (p-Butoxybenzyl)hyoscyaminium bromide
  • 1αH,5αH-Tropanium, 8-(p-butoxybenzyl)-3α-hydroxy-, bromide, (-)-tropate (8CI)
  • 8-Azoniabicyclo[3.2.1]octane, 8-[(4-butoxyphenyl)methyl]-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-, bromide, [3(S)-endo]-
  • BHB
  • Coliopan
  • N-(Butoxybenzyl)hyoscyamine bromide
  • butoxybenzyl hyoscyamine
  • Butropan
  • [3(S)-endo]-
  • 29025-14-7
  • C28H38NO4Br
  • C28H38BrNO4
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals