glisoxepide
- Product Name
- glisoxepide
- CAS No.
- 25046-79-1
- Chemical Name
- glisoxepide
- Synonyms
- FBB-4231;RP-22410;Pro-Diaban;BAY B-4231;Glisoxepid;glisoxepide;Glisoxepid (10mM in DMSO);N-[2-[4-(azepan-1-ylcarbamoylsulfamoyl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide;3-Isoxazolecarboxamide, N-[2-[4-[[[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl-;Pivaloyloxymethyl [2S-(2?,5?,6?)]-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrochloride
- CBNumber
- CB7880449
- Molecular Formula
- C20H27N5O5S
- Formula Weight
- 449.529
- MOL File
- 25046-79-1.mol
glisoxepide Property
- Melting point:
- 189°
- Density
- 1.2348 (rough estimate)
- refractive index
- 1.6460 (estimate)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
- form
- Solid
- pka
- 5.92±0.10(Predicted)
- color
- Pale Yellow to Yellow
Safety
- Toxicity
- LD50 in mice, rats, cats, dogs (g/kg): >10.0, >10.0, >4.0, >2.0 orally; in mice, rats (mg/kg): 283, 196 i.v. (Tettenborn)
N-Bromosuccinimide Price
- Product number
- G410600
- Product name
- Glisoxepid
- Packaging
- 100mg
- Price
- $1355
- Updated
- 2021/12/16
- Product number
- API0009129
- Product name
- GLISOXEPIDE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $1871.1
- Updated
- 2021/12/16
- Product number
- API0009129
- Product name
- GLISOXEPIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $315
- Updated
- 2021/12/16
glisoxepide Chemical Properties,Usage,Production
Originator
Pro-Diaban,Bayer,W. Germany,1974
Uses
Labelled Glisoxepid (G410600). Glisoxepid is used as an antidiabetic drug. Glisoxepid is a sulfonylurea derivative used in the treatment of diabetes mellitus type 2.
Definition
ChEBI: Glisoxepide is a sulfonamide.
Manufacturing Process
There is obtained from 4-[β-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl]-
benzene-sulfonamide (prepared from 5-methyl-isoxazole-(3)-carboxylic acid
chloride and 4-(β-aminoethyl)benzene-sulfonamide hydrochloride, MP 213° to
214°C in pyridine) and chloroformic acid methyl ester, in a yield of 69%, the
compound N-[[-4-[β-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl]]-benzenesulfonyl]]-methyl-urethane in the form of colorless crystals of MP 173°C.
From the sulfonyl-urethane described above and N-amino-hexamethyleneimine, there is obtained, in a yield of 70%. the compound 4-[[4-[β-[5-methylisoxazolyl-(3)-carboxamido]-ethyl]-benzene-sulfonyl]]-1,1-hexamethylenesemicarbazide in the form of colorless crystals of MP 189°C.
Therapeutic Function
Oral hypoglycemic
glisoxepide Preparation Products And Raw materials
Raw materials
Preparation Products
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