4-(2-Aminoethyl)benzenesulfonamide
Uses- Product Name
- 4-(2-Aminoethyl)benzenesulfonamide
- CAS No.
- 35303-76-5
- Chemical Name
- 4-(2-Aminoethyl)benzenesulfonamide
- Synonyms
- TIMTEC-BB SBB003544;OTAVA-BB BB7020410047;Glipizide Impurity 32;Glipizide Impurity 14;LABOTEST-BB LT00080735;Glimepiride Impurity 26;4-Aminoethylbenzenesulfonamide;P-Aminoethylbenzenesulfonamide;Glimepiride Sulfonamide Impurity;4-(2-Aminoethyl)benzesulfonamide
- CBNumber
- CB5480434
- Molecular Formula
- C8H12N2O2S
- Formula Weight
- 200.26
- MOL File
- 35303-76-5.mol
4-(2-Aminoethyl)benzenesulfonamide Property
- Melting point:
- 150-152 °C (lit.)
- Boiling point:
- 387.4±44.0 °C(Predicted)
- Density
- 1.2581 (rough estimate)
- vapor pressure
- 0Pa at 25℃
- refractive index
- 1.5690 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 10.16±0.10(Predicted)
- form
- Solid
- color
- White
- Water Solubility
- 15.5g/L at 20℃
- InChI
- InChI=1S/C8H12N2O2S/c9-6-5-7-1-3-8(4-2-7)13(10,11)12/h1-4H,5-6,9H2,(H2,10,11,12)
- InChIKey
- FXNSVEQMUYPYJS-UHFFFAOYSA-N
- SMILES
- C1(S(N)(=O)=O)=CC=C(CCN)C=C1
- LogP
- -3.1 at 19.8℃
- CAS DataBase Reference
- 35303-76-5(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi,Xn
- Risk Statements
- 34-22-36/37/38-20/21/22
- Safety Statements
- 45-36/37/39-26-36-24/25
- RIDADR
- UN3259
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29350090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H290May be corrosive to metals
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P234Keep only in original container.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 275247
- Product name
- 4-(2-Aminoethyl)benzenesulfonamide
- Purity
- 99%
- Packaging
- 25g
- Price
- $96.9
- Updated
- 2025/07/31
- Product number
- A1363
- Product name
- 4-(2-Aminoethyl)benzenesulfonamide
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $61
- Updated
- 2025/07/31
- Product number
- A608790
- Product name
- 4-(2-Aminoethyl)benzenesulfonamide
- Packaging
- 10g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- JK192954
- Product name
- 4-(2-Aminoethyl)benzenesulfonamide
- Purity
- 99%
- Packaging
- 25g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FA10909
- Product name
- 4-(2-Aminoethyl)benzene sulfonamide
- Packaging
- 5G
- Price
- $60
- Updated
- 2021/12/16
4-(2-Aminoethyl)benzenesulfonamide Chemical Properties,Usage,Production
Uses
4-(2-Aminoethyl)benzenesulfonamide is used as the starting material in the synthesis of Des(5-methylpyrazinecarbonyl) trans-4-Methyl Glipizide (D292605); a degradation product of Glimepiride (G410150) which is a sulfonylurea hypoglycemic agent and an antidiabetic. 4-(2-Aminoethyl)benzenesulfonamide is also used as a reagent in the synthesis of deorphaning pyrrolopyrazines as potent multi-target antimalarial agents.
Chemical Properties
white to yellowish crystalline powder
Uses
4-(2-Aminoethyl)benzenesulfonamide was used to develop a model system to study the implementation of a microfluid chip required for Fourier transform measurements of biochemical interactions.
General Description
The human hepatocellular carcinoma (HCC) cells were treated with its inhibitor 4-(2-aminoethyl)benzenesulfonamide.
Flammability and Explosibility
Not classified
Synthesis
223253-87-0
35303-76-5
The general procedure for the synthesis of 4-(2-aminoethyl)benzenesulfonamide from the compound (CAS:223253-87-0) was as follows: compound II was dissolved in 80 mL of acetone. Under the condition of ice water bath, 150 mL of concentrated ammonia was added to the reaction mixture and the reaction was stirred at room temperature. After completion of the reaction, the mixture was poured into 500 mL of ice water and the solid was collected by filtration. The filter cake was acidified with 200 mL of 2N hydrochloric acid. Subsequently, the mixture was heated to reflux for 6 hours and filtered. The filtrate was dissolved in hot water and the pH was adjusted to 11-12 with 2N KOH solution. after cooling in an ice bath, the solution was boiled naturally and cooled again to precipitate a pale yellow precipitate. After filtration, it was dried under vacuum to obtain 21.6 g (0.108 mol) of compound III, i.e., 4-(2-aminoethyl)benzenesulfonamide.
References
[1] Patent: CN107879955, 2018, A. Location in patent: Paragraph 0050
4-(2-Aminoethyl)benzenesulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(2-Aminoethyl)benzenesulfonamide manufacturers
- Product
- Glipizide Impurity 4 35303-76-5
- Price
- US $0.00-0.00/mg
- Min. Order
- 5mg
- Purity
- 95%+
- Supply Ability
- 1000mg
- Release date
- 2025-02-10
- Product
- 4-(2-Aminoethyl)benzene sulfonamide 35303-76-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 4-(2-Aminoethyl)benzene sulfonamide 35303-76-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09