[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride
- Product Name
- [R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride
- CAS No.
- 16777-42-7
- Chemical Name
- [R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride
- Synonyms
- D 563;Modacor;Ildamen;FDA 1576;OXYFEDRINE HCL;L-OXYFEDRINE HCL;Ildamen USP/EP/BP;L-Form hydrochloride;Oxyfedrine L-form HCl;OXYFEDRINEHYROCHLORIDE
- CBNumber
- CB7882175
- Molecular Formula
- C19H24ClNO3
- Formula Weight
- 349.85176
- MOL File
- 16777-42-7.mol
[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Property
- Melting point:
- 192-194℃
- form
- Solid
- color
- White to off-white
Safety
- Toxicity
- LD50 in mice (mg/kg): 29 i.v. (Hueller)
N-Bromosuccinimide Price
- Product number
- API0005074
- Product name
- OXYFEDRINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.96
- Updated
- 2021/12/16
[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Chemical Properties,Usage,Production
Originator
Ildamen,Homburg,W. Germany ,1966
Uses
Oxyfedrine hydrochloride, a vasodilator, is an orally active β-adrenoreceptor agonist. Oxyfedrine decreases the tonicity of coronary vessels. Oxyfedrine hydrochloride can be used in the research of cardiovascular disease[1][2].
Manufacturing Process
45 grams of m-methoxy acetophenone, 8 grams of paraformaldehyde and 30.2 grams of 1 norephedrine were mixed with about 135 cc of isopropanol HCl solution to provide a pH of 4 and the mixture refluxed for 4 hours. The reaction mixture was cooled and the crystals filtered off on a suction filter. 3[1-phenyl-1-hydroxypropyl-(2)-amino]-1-(m-methoxyphenyl)-propanone-(1) HCl was obtained which after recrystallization from methanol had a MP of 190° to 193°C.
Therapeutic Function
Coronary vasodilator
in vivo
Oxyfedrine (14 mg/kg, p.o., for 3-4 weeks) shows anti-anginal action in cats[2].
Oxyfedrine (10 mg/kg, i.p., HCT116 cell xenograft mice) suppresses tumor growth when combined with sulfasalazine (SSZ, 350 mg/kg, i.p.)[1].
Oxyfedrine (1 mg/kg, i.v.) decreases the arterial and venous blood high blood viscosity (HBV) in ice water stress rats[3].
References
[1] Otsuki Y, et al. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy. Cancer Sci. 2020 Jan;111(1):127-136. DOI:10.1111/cas.14224
[2] Parratt JR. The haemodynamic effects of prolonged oral administration of oxyfedrine, a partial agonist at beta-adrenoceptors: comparison with propranolol. Br J Pharmacol. 1974 May;51(1):5-13. DOI:10.1111/j.1476-5381.1974.tb09625.x
[3] Yu J, et al. [Effects of oxyfedrine on high blood viscosity and myocardial necrosis induced by epinephrine and ice water stress in rats]. Zhongguo Yao Li Xue Bao. 1993 Jul;14(4):364-6. PMID:8249637
[4] Mackenzie JE, et al. Effects of oxyfedrine on isolated portal vein and other smooth muscles. Br J Pharmacol. 1973 Apr;47(4):827-37. DOI:10.1111/j.1476-5381.1973.tb08210.x
[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from [R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride manufacturers
- Product
- Oxyfedrine hydrochloride 16777-42-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-11
- Product
- [R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride 16777-42-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25