azidamfenicol

ChemicalBook > CAS DataBase List > azidamfenicol

Product Name: azidamfenicol
CAS No.: 13838-08-9
Chemical Name: azidamfenicol
Synonyms: azidamfenicol;azidoamphenicol;AZIAMPHENICOL, PHARMA;AzidoaMphenicol, LeukoMycin N;azidamfenicol ISO 9001：2015 REACH;Ketoprofen Impurity 13(S-Isomer) Trometamol;2-azido-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide;2-Azido-N-[(1R,2R)-2-hydroxy-1-hydroxymethyl-2-(4-nitrophenyl)ethyl]acetamide;Acetamide, 2-azido-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-;Antibiotic,Bacterial,bacteria,Azidamfenicol,Inhibitor,peptidyltransferase,Gram-positive,Gram-negative,inhibit,ribosomal
CBNumber: CB7884098
Molecular Formula: C11H13N5O5
Formula Weight: 295.254
MOL File: 13838-08-9.mol

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azidamfenicol Property

Melting point:: 107°
alpha: D20 -20° (c = 1.6 in ethyl acetate)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: Ethyl Acetate (Slightly, Sonicated), Methanol (Slightly)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25449
Product name: Azidamfenicol
Purity: ≥99%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 25449
Product name: Azidamfenicol
Purity: ≥99%
Packaging: 5mg
Price: $216
Updated: 2024/03/01

TRC

Product number: A926853
Product name: Azidamfenicol
Packaging: 5mg
Price: $1620
Updated: 2021/12/16

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azidamfenicol Chemical Properties,Usage,Production

Originator

Berlicetin-,Chauvin

Uses

Azidamfenicol is a semi-synthetic chloramphenicol in which the nitro moiety is replaced with a methylsulphone and the dichloroacetamide is replaced with azidoacetamide, first synthesised at Bayer in 1959. Azidamfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Azidamfenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Azidamfenicol has received little research attention with only a few literature citations.

Definition

ChEBI: Azidamfenicol is an organonitrogen compound and an organooxygen compound. It is functionally related to an alpha-amino acid.

Manufacturing Process

21.2 g of D-(-)-threo-1-p-nitrophenyl-2-aminopropane-1,3-diol are stirred with 10 g of azidoacetonitrile (B.P. 68°C/25 mm) in a mixture of 125 ml of methanol and 125 ml of water at 30-40°C for a few days. The mixture is filtered off from a little undissolved base and the solvent is distilled in vacuo. The residue is treated with a little normal hydrochloric acid until acid to Congo red and extracted with ethylacetate. By evaporating the solvent and recrystallizing the residue from ethylene chloride is obtained D-(-)-threo-1-pnitrophenyl- 2-azidoacetylamino-propane-1,3-diol, M.P. 107°C.

Therapeutic Function

Antibiotic

azidamfenicol Preparation Products And Raw materials

Raw materials

Preparation Products

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13838-08-9, azidamfenicolRelated Search:

Ethyl acetate Chloramphenicol azidamfenicol 2-Amino-1-(4-nitrophenyl)-1,3-propanediol

azidamfenicol

AZIAMPHENICOL, PHARMA

azidoamphenicol

2-Azido-N-[(1R,2R)-2-hydroxy-1-hydroxymethyl-2-(4-nitrophenyl)ethyl]acetamide

AzidoaMphenicol, LeukoMycin N

2-azido-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide

azidamfenicol ISO 9001：2015 REACH

Antibiotic,Bacterial,bacteria,Azidamfenicol,Inhibitor,peptidyltransferase,Gram-positive,Gram-negative,inhibit,ribosomal

Ketoprofen Impurity 13(S-Isomer) Trometamol

Acetamide, 2-azido-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-

13838-08-9