azidamfenicol
- Product Name
- azidamfenicol
- CAS No.
- 13838-08-9
- Chemical Name
- azidamfenicol
- Synonyms
- azidamfenicol;azidoamphenicol;AZIAMPHENICOL, PHARMA;AzidoaMphenicol, LeukoMycin N;azidamfenicol ISO 9001：2015 REACH;Ketoprofen Impurity 13(S-Isomer) Trometamol;2-azido-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide;2-Azido-N-[(1R,2R)-2-hydroxy-1-hydroxymethyl-2-(4-nitrophenyl)ethyl]acetamide;Acetamide, 2-azido-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-;Antibiotic,Bacterial,bacteria,Azidamfenicol,Inhibitor,peptidyltransferase,Gram-positive,Gram-negative,inhibit,ribosomal
- CBNumber
- CB7884098
- Molecular Formula
- C11H13N5O5
- Formula Weight
- 295.254
- MOL File
- 13838-08-9.mol
azidamfenicol Property
- Melting point:
- 107°
- alpha
- D20 -20° (c = 1.6 in ethyl acetate)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Ethyl Acetate (Slightly, Sonicated), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25449
- Product name
- Azidamfenicol
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 25449
- Product name
- Azidamfenicol
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- A926853
- Product name
- Azidamfenicol
- Packaging
- 5mg
- Price
- $1620
- Updated
- 2021/12/16
azidamfenicol Chemical Properties,Usage,Production
Originator
Berlicetin-,Chauvin
Uses
Azidamfenicol is a semi-synthetic chloramphenicol in which the nitro moiety is replaced with a methylsulphone and the dichloroacetamide is replaced with azidoacetamide, first synthesised at Bayer in 1959. Azidamfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Azidamfenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Azidamfenicol has received little research attention with only a few literature citations.
Definition
ChEBI: Azidamfenicol is an organonitrogen compound and an organooxygen compound. It is functionally related to an alpha-amino acid.
Manufacturing Process
21.2 g of D-(-)-threo-1-p-nitrophenyl-2-aminopropane-1,3-diol are stirred with 10 g of azidoacetonitrile (B.P. 68°C/25 mm) in a mixture of 125 ml of methanol and 125 ml of water at 30-40°C for a few days. The mixture is filtered off from a little undissolved base and the solvent is distilled in vacuo. The residue is treated with a little normal hydrochloric acid until acid to Congo red and extracted with ethylacetate. By evaporating the solvent and recrystallizing the residue from ethylene chloride is obtained D-(-)-threo-1-pnitrophenyl- 2-azidoacetylamino-propane-1,3-diol, M.P. 107°C.
Therapeutic Function
Antibiotic
azidamfenicol Preparation Products And Raw materials
Raw materials
Preparation Products
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