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thiopropazate

Product Name
thiopropazate
CAS No.
84-06-0
Chemical Name
thiopropazate
Synonyms
Dartal;Dartalan;hiopropazate;thiopropazate;4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol=acetate;1-Piperazineethanol, 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, 1-acetate;Acetic acid 2-[4-[3-(2-chloro--10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl;Acetic acid 2-[4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl ester
CBNumber
CB7887882
Molecular Formula
C23H28ClN3O2S
Formula Weight
446.01
MOL File
84-06-0.mol
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thiopropazate Property

Boiling point:
bp0.1 214-218°
Density 
1.1147 (rough estimate)
refractive index 
1.6100 (estimate)
pka
pKa 3.20(H2O (extrap) t = 24±1 I ~ 0.002) (Uncertain);7.15(H2O (extrap) t = 24±1 I ~ 0.002) (Uncertain)
Water Solubility 
8.92mg/L(24 ºC)
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Safety

Hazardous Substances Data
84-06-0(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0012614
Product name
THIOPROPAZATE
Purity
95.00%
Packaging
5MG
Price
$495.85
Updated
2021/12/16
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thiopropazate Chemical Properties,Usage,Production

Originator

Dartal,Searle,US,1957

Definition

ChEBI: A phenothiazine derivative in which 10H-phenothiazine has a chloro subsitituent at the 2-position and a 3-[4-(2-acetoxyethyl)piperazin-1-yl]propyl group at N-10.

Manufacturing Process

A mixture of 155 parts of 2-chloro-10-(γ-chloropropyl)phenothiazine, 75 parts of sodium iodide, 216 parts of piperazine and 2,000 parts of butanone is refluxed for 8 hours, concentrated and extracted with dilute hydrochloric acid. The extract is rendered alkaline by addition of dilute potassium carbonate and extracted with ether. This ether extract is washed with water, dried over anhydrous potassium carbonate, filtered and evaporated. Vacuum distillation at 0.1 mm pressure yields 2-chloro-10-(γ-piperazinopropyl)phenothiazine at about 214°C to 218°C.
A mixture of 50 parts of the distillate, 25.6 parts of β-bromoethyl acetate, 10.7 parts of potassium carbonate and 400 parts of toluene is stirred at reflux temperature for 16 hours. The mixture is heated with water. The organic layer is separated, washed with water and extracted with dilute hydrochloric acid. The resulting extract is washed with benzene, rendered alkaline and extracted with benzene. The resulting benzene solution is dried over anhydrous potassium carbonate, filtered and concentrated. The residue is dissolved in 300 parts of ethanol and treated with 2.2 equivalents of a 25% solution of anhydrous hydrochloric acid in 2-propanol. The resulting crystals are recrystallized from 400 parts of ethanol and 10 parts of water. The dihydrochloride of N-(β-acetoxyethyl)-N'-[γ-(2'-chloro-10'- phenothiazine)propyl]piperazine melts unsharply at about 200°C to 230°C.

brand name

Thiopropazate is INN and BAN.

Therapeutic Function

Antipsychotic

thiopropazate Preparation Products And Raw materials

Raw materials

Preparation Products

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thiopropazate Suppliers

Hu Bei Jiutian Bio-medical Technology CO.,Ltd
Tel
027-88013699 17354350817
Email
Ryan@jiutian-bio.com
Country
China
ProdList
6001
Advantage
58
Shaanxi Didu New Materials Co. Ltd
Tel
+86-89586680 +86-13289823923
Email
1026@dideu.com
Country
China
ProdList
8670
Advantage
58

84-06-0, thiopropazateRelated Search:


  • thiopropazate
  • 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol=acetate
  • Acetic acid 2-[4-[3-(2-chloro--10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl
  • Acetic acid 2-[4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl ester
  • Dartal
  • Dartalan
  • 1-Piperazineethanol, 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, 1-acetate
  • hiopropazate
  • 84-06-0