ditazole
- Product Name
- ditazole
- CAS No.
- 18471-20-0
- Chemical Name
- ditazole
- Synonyms
- S-222;Apt-574;ditazol;ditazole;Agerophas;Diethamphenazole;2,2'-[(4,5-Diphenyl-2-oxazolyl)imino]bisethanol;Ethanol, 2,2'-[(4,5-diphenyl-2-oxazolyl)imino]bis-;2-[(4,5-diphenyl-1,3-oxazol-2-yl)-(2-hydroxyethyl)amino]ethanol
- CBNumber
- CB7899041
- Molecular Formula
- C19H20N2O3
- Formula Weight
- 324.37
- MOL File
- 18471-20-0.mol
ditazole Property
- Melting point:
- 100-101°C
- Boiling point:
- 505.5±60.0 °C(Predicted)
- Density
- 1.237±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.08±0.10(Predicted)
- color
- White to Off-White
N-Bromosuccinimide Price
- Product number
- D493725
- Product name
- Ditazole
- Packaging
- 2mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- API0011255
- Product name
- DITAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.1
- Updated
- 2021/12/16
ditazole Chemical Properties,Usage,Production
Originator
Ageroplas,Serona,Italy,1973
Uses
Ditazole is a weak anti-inflammatory drug and a novel inhibitor of platelet aggregation.
Definition
ChEBI: Ditazole is a member of 1,3-oxazoles.
Manufacturing Process
A solution of 5.1 grams 2-chloro-4,5-diphenyl-oxazole, 6.3 grams diethanolamine and 50 ml absolute ethanol was refluxed for 4 hours. The solvent was stripped at 1 mm and the oily residue was added at 60°C to 100 ml 50% ethanol; by cooling the hydro-alcoholic solution, 4.5 grams of 2-bis(β- hydroxyethyl)amino-4,5-diphenyl-oxazole was obtained (yield, 69.5%). The product crystallized from ethyl ether + petroleum ether, with a MP of 96 to 98°C.
Therapeutic Function
Antiinflammatory
Trade name
Ageroplas (Lepori, Spain; Serono, Italy), Fendazol (Lepori, Portugal).
Mechanism of action
Ditazole is an anti-inflammatory analgesic agent that is of interest primarily for its ability to inhibit platelet aggregation. For example, it normalizes the enhanced platelet activity in cerebrovascular patients suffering transient ischemic attacks.
Synthesis
ditazole is prepared by heating 2-
chloro-4,5-diphenyloxazole and diethanolamine
in ethanol.
ditazole Preparation Products And Raw materials
Raw materials
Preparation Products
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