ditazole

Product Name: ditazole
CAS No.: 18471-20-0
Chemical Name: ditazole
Synonyms: S-222;Apt-574;ditazol;ditazole;Agerophas;Diethamphenazole;2,2'-[(4,5-Diphenyl-2-oxazolyl)imino]bisethanol;Ethanol,2,2'-[(4,5-diphenyl-2-oxazolyl)imino]bis-;Ethanol, 2,2'-[(4,5-diphenyl-2-oxazolyl)imino]bis-;2-[(4,5-diphenyl-1,3-oxazol-2-yl)-(2-hydroxyethyl)amino]ethanol
CBNumber: CB7899041
Molecular Formula: C19H20N2O3
Formula Weight: 324.37
MOL File: 18471-20-0.mol

More

Less

ditazole Property

Melting point:: 100-101°C
Boiling point:: 505.5±60.0 °C(Predicted)
Density: 1.237±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.08±0.10(Predicted)
color: White to Off-White

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: D493725
Product name: Ditazole
Packaging: 2mg
Price: $50
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0011255
Product name: DITAZOLE
Purity: 95.00%
Packaging: 5MG
Price: $504.1
Updated: 2021/12/16

More

Less

ditazole Chemical Properties,Usage,Production

Originator

Ageroplas,Serona,Italy,1973

Uses

Ditazole is a weak anti-inflammatory drug and a novel inhibitor of platelet aggregation.

Definition

ChEBI: Ditazole is a member of 1,3-oxazoles.

Manufacturing Process

A solution of 5.1 grams 2-chloro-4,5-diphenyl-oxazole, 6.3 grams diethanolamine and 50 ml absolute ethanol was refluxed for 4 hours. The solvent was stripped at 1 mm and the oily residue was added at 60°C to 100 ml 50% ethanol; by cooling the hydro-alcoholic solution, 4.5 grams of 2-bis(β- hydroxyethyl)amino-4,5-diphenyl-oxazole was obtained (yield, 69.5%). The product crystallized from ethyl ether + petroleum ether, with a MP of 96 to 98°C.

Therapeutic Function

Antiinflammatory

Trade name

Ageroplas (Lepori, Spain; Serono, Italy), Fendazol (Lepori, Portugal).

Mechanism of action

Ditazole is an anti-inflammatory analgesic agent that is of interest primarily for its ability to inhibit platelet aggregation. For example, it normalizes the enhanced platelet activity in cerebrovascular patients suffering transient ischemic attacks.

Synthesis

ditazole is prepared by heating 2- chloro-4,5-diphenyloxazole and diethanolamine in ethanol.

ditazole Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ditazole Suppliers

CHINA 8 United States 1 Global 9

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44806
Advantage: 58

Hubei Nordina Biotechnology Co., Ltd.

Tel: 19371278702
Fax: 18162687220
Email: nuodinashengwu@163.com
Country: China
ProdList: 971
Advantage: 58

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

Tel: 17691182729 18161915376
Email: 1046@dideu.com
Country: China
ProdList: 10001
Advantage: 58

Hubei huizepu Pharmaceutical Technology Co., Ltd

Tel: 023-19371278 19371278702
Email: n13164103386@163.com
Country: China
ProdList: 3277
Advantage: 58

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 73043
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

18471-20-0, ditazoleRelated Search:

2-AMINO-4-METHYLOXAZOLE Oxazole, 4,5-diphenyl-2-((2-hydroxyethyl)amino)- 5-METHYL-OXAZOL-2-YLAMINE Oxazole-2-amine ditazole 4,5-dimethyloxazol-2-amine 5-PHENYL-OXAZOL-2-YLAMINE 4,5-Diphenyl-2-(N-ethyl-N-(2-hydroxyethyl)amino)oxazole

2,2'-[(4,5-Diphenyl-2-oxazolyl)imino]bisethanol

Agerophas

Apt-574

Diethamphenazole

S-222

ditazole

ditazol

2-[(4,5-diphenyl-1,3-oxazol-2-yl)-(2-hydroxyethyl)amino]ethanol

Ethanol, 2,2'-[(4,5-diphenyl-2-oxazolyl)imino]bis-

Ethanol,2,2'-[(4,5-diphenyl-2-oxazolyl)imino]bis-

18471-20-0