Oxazole-2-amine
- Product Name
- Oxazole-2-amine
- CAS No.
- 4570-45-0
- Chemical Name
- Oxazole-2-amine
- Synonyms
- oxazol-2-amine;2-AMINO-OXAZOLE;2-OxazolaMine;2-AMINOXAZOLE;Oxazole-2-amine;OXAZOL-2-YLAMINE;OXAZOLE-2-YLAMINE;1,3-OXAZOL-2-AMINE;2-Aminooxazole >2-Aminooxazole,97%
- CBNumber
- CB8262819
- Molecular Formula
- C3H4N2O
- Formula Weight
- 84.08
- MOL File
- 4570-45-0.mol
Oxazole-2-amine Property
- Melting point:
- 93-95℃
- Boiling point:
- 186.7±23.0 °C(Predicted)
- Density
- 1.241±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Soluble), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 5.45±0.10(Predicted)
- color
- Off-White to Pale Yellow
- λmax
- 219nm(MeOH)(lit.)
- InChI
- InChI=1S/C3H4N2O/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)
- InChIKey
- ACTKAGSPIFDCMF-UHFFFAOYSA-N
- SMILES
- O1C=CN=C1N
- CAS DataBase Reference
- 4570-45-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 34-36/37/38
- Safety Statements
- 26-36/37/39-45-24/25
- RIDADR
- 2735
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 739731
- Product name
- 2-Aminooxazole
- Purity
- 97%
- Packaging
- 500mg
- Price
- $116
- Updated
- 2025/07/31
- Product number
- A2884
- Product name
- 2-Aminooxazole
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $128
- Updated
- 2024/03/01
- Product number
- A2884
- Product name
- 2-Aminooxazole
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $511
- Updated
- 2023/06/20
- Product number
- A618745
- Product name
- 2-Aminooxazole
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- A618745
- Product name
- 2-Aminooxazole
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
Oxazole-2-amine Chemical Properties,Usage,Production
Uses
2-Aminooxazole is a chemical reagent used in the synthesis of novel inhibitors of the kinetoplastid Trypanosoma brucei.
Synthesis
420-04-2
141-46-8
4570-45-0
Example 2: Preparation of 2-aminooxazole. To a tetrahydrofuran (THF, 60 mL) solution of cyanamide (19.8 mL, 50% w/w aqueous solution, 0.25 mol) was added a 24 mL aqueous solution of 2-hydroxyacetaldehyde (15 g, 0.25 mol). The reaction mixture was treated with 2 M aqueous sodium hydroxide (25.2 mL, 0.05 mol) at 0 °C. The mixture was slowly warmed to room temperature and stirred continuously for 24 hours. Upon completion of the reaction, the volatile solvent (THF) was removed by distillation under reduced pressure. The remaining aqueous solution was extracted with ethyl acetate (4 × 200 mL). The organic phases were combined, dried with anhydrous sodium sulfate, and subsequently concentrated under reduced pressure to give 14.968 g (71.3% yield) of white solid product. The product was characterized by 400 MHz 1H NMR (CDCl3): δ 7.13 (s, 1H), 6.74 (s, 1H), 5.26 (br.s, 2H). Elemental analysis calculated values (C3H4N2O): C 42.86%, H 4.80%, N 33.32%; measured values: C 43.01%, H 4.87%, N 33.11%.
References
[1] Patent: WO2007/123892, 2007, A2. Location in patent: Page/Page column 50
[2] Patent: WO2004/110990, 2004, A2. Location in patent: Page 37
[3] Patent: WO2006/44869, 2006, A1. Location in patent: Page/Page column 132
[4] Chemistry - A European Journal, 2013, vol. 19, # 14, p. 4586 - 4595
[5] Synthesis, 1976, p. 591 - 593
Oxazole-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Oxazole-2-amine manufacturers
- Product
- Oxazole-2-amine 4570-45-0
- Price
- US $780.00/g
- Min. Order
- 1g
- Purity
- 97
- Supply Ability
- 500 Kg
- Release date
- 2024-02-23
- Product
- Oxazole-2-amine 4570-45-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Oxazole-2-amine 4570-45-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09