ChemicalBook > CAS DataBase List > Oxazole-2-amine

Oxazole-2-amine

Product Name
Oxazole-2-amine
CAS No.
4570-45-0
Chemical Name
Oxazole-2-amine
Synonyms
oxazol-2-amine;2-AMINO-OXAZOLE;2-OxazolaMine;2-AMINOXAZOLE;Oxazole-2-amine;OXAZOL-2-YLAMINE;OXAZOLE-2-YLAMINE;1,3-OXAZOL-2-AMINE;2-Aminooxazole >2-Aminooxazole,97%
CBNumber
CB8262819
Molecular Formula
C3H4N2O
Formula Weight
84.08
MOL File
4570-45-0.mol
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Oxazole-2-amine Property

Melting point:
93-95℃
Boiling point:
186.7±23.0 °C(Predicted)
Density 
1.241±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Soluble), Ethyl Acetate (Slightly)
form 
Solid
pka
5.45±0.10(Predicted)
color 
Off-White to Pale Yellow
λmax
219nm(MeOH)(lit.)
InChI
InChI=1S/C3H4N2O/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)
InChIKey
ACTKAGSPIFDCMF-UHFFFAOYSA-N
SMILES
O1C=CN=C1N
CAS DataBase Reference
4570-45-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
34-36/37/38
Safety Statements 
26-36/37/39-45-24/25
RIDADR 
2735
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
739731
Product name
2-Aminooxazole
Purity
97%
Packaging
500mg
Price
$116
Updated
2025/07/31
TCI Chemical
Product number
A2884
Product name
2-Aminooxazole
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$128
Updated
2024/03/01
TCI Chemical
Product number
A2884
Product name
2-Aminooxazole
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$511
Updated
2023/06/20
TRC
Product number
A618745
Product name
2-Aminooxazole
Packaging
500mg
Price
$80
Updated
2021/12/16
TRC
Product number
A618745
Product name
2-Aminooxazole
Packaging
100mg
Price
$50
Updated
2021/12/16
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Oxazole-2-amine Chemical Properties,Usage,Production

Uses

2-Aminooxazole is a chemical reagent used in the synthesis of novel inhibitors of the kinetoplastid Trypanosoma brucei.

Synthesis

420-04-2

141-46-8

4570-45-0

Example 2: Preparation of 2-aminooxazole. To a tetrahydrofuran (THF, 60 mL) solution of cyanamide (19.8 mL, 50% w/w aqueous solution, 0.25 mol) was added a 24 mL aqueous solution of 2-hydroxyacetaldehyde (15 g, 0.25 mol). The reaction mixture was treated with 2 M aqueous sodium hydroxide (25.2 mL, 0.05 mol) at 0 °C. The mixture was slowly warmed to room temperature and stirred continuously for 24 hours. Upon completion of the reaction, the volatile solvent (THF) was removed by distillation under reduced pressure. The remaining aqueous solution was extracted with ethyl acetate (4 × 200 mL). The organic phases were combined, dried with anhydrous sodium sulfate, and subsequently concentrated under reduced pressure to give 14.968 g (71.3% yield) of white solid product. The product was characterized by 400 MHz 1H NMR (CDCl3): δ 7.13 (s, 1H), 6.74 (s, 1H), 5.26 (br.s, 2H). Elemental analysis calculated values (C3H4N2O): C 42.86%, H 4.80%, N 33.32%; measured values: C 43.01%, H 4.87%, N 33.11%.

References

[1] Patent: WO2007/123892, 2007, A2. Location in patent: Page/Page column 50
[2] Patent: WO2004/110990, 2004, A2. Location in patent: Page 37
[3] Patent: WO2006/44869, 2006, A1. Location in patent: Page/Page column 132
[4] Chemistry - A European Journal, 2013, vol. 19, # 14, p. 4586 - 4595
[5] Synthesis, 1976, p. 591 - 593

Oxazole-2-amine Preparation Products And Raw materials

Raw materials

Sodium sulfate Tetrahydrofuran Diethyl ether Ethyl acetate Sodium hydroxide PETROLEUM ETHER Cyanamide GLYCOLALDEHYDE

Preparation Products

Idoxuridine
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View Lastest Price from Oxazole-2-amine manufacturers

R&D Scientific Inc.
Product
Oxazole-2-amine 4570-45-0
Price
US $780.00/g
Min. Order
1g
Purity
97
Supply Ability
500 Kg
Release date
2024-02-23
Zhuozhou Wenxi import and Export Co., Ltd
Product
Oxazole-2-amine 4570-45-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Oxazole-2-amine 4570-45-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

4570-45-0, Oxazole-2-amineRelated Search:

Triethanolamine Triallylamine Fenoxaprop-p-ethyl Acetaminophen Aminopyrine Oxazole Glucosamine Isoxazole Famoxadone Dibenzylamine Bis(2-ethylhexyl)amine Sulfamic acid Sulfamethoxazole Sulfisoxazole EC 2.6.1.2 Zoxazolamine 5-PHENYL-OXAZOL-2-YLAMINE 2-HYDRAZINO-1,3-BENZOXAZOLE

  • 2-AMINO-OXAZOLE
  • 1,3-OXAZOL-2-AMINE
  • 2-Amino-1,3-oxazole
  • 2-AMINOXAZOLE
  • OXAZOLE-2-YLAMINE
  • Oxazole-2-amine
  • OXAZOL-2-YLAMINE
  • oxazol-2-amine
  • 2-Amino Oxazole Or 1,3-Oxazol-2-amine
  • 2-OxazolaMine
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  • 2-Aminooxazole &gt
  • 2-Aminooxazole,97%
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