Zoxazolamine
- Product Name
- Zoxazolamine
- CAS No.
- 61-80-3
- Chemical Name
- Zoxazolamine
- Synonyms
- Zoxine;Flexin;Zoxamin;McN-485;Deflexol;Flexilon;usafma-12;NSC 24995;Contrazole;USAF ma-12
- CBNumber
- CB7464410
- Molecular Formula
- C7H5ClN2O
- Formula Weight
- 168.58
- MOL File
- 61-80-3.mol
Zoxazolamine Property
- Melting point:
- 181-184 °C(lit.)
- Boiling point:
- 316.8±34.0 °C(Predicted)
- Density
- 1.4369 (rough estimate)
- refractive index
- 1.5618 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO, Methanol
- pka
- 0.73±0.10(Predicted)
- form
- Powder
- color
- Light brown to yellow-brown
- Merck
- 13,10249
- CAS DataBase Reference
- 61-80-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Zoxazolamine(61-80-3)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- DM4550000
- HS Code
- 29349990
- Toxicity
- LD50 in mice, rats (mg/kg): 376, 102 i.p.; 678, 730 orally (Cain, Roszkowski)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A45807
- Product name
- 2-Amino-5-chlorobenzoxazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $188
- Updated
- 2024/03/01
- Product number
- A45807
- Product name
- 2-Amino-5-chlorobenzoxazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $58.7
- Updated
- 2023/06/20
- Product number
- 17565
- Product name
- Zoxazolamine
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17565
- Product name
- Zoxazolamine
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $109
- Updated
- 2024/03/01
- Product number
- A45807
- Product name
- 2-Amino-5-chlorobenzoxazole
- Purity
- 97%
- Packaging
- 25g
- Price
- $572
- Updated
- 2024/03/01
Zoxazolamine Chemical Properties,Usage,Production
Chemical Properties
LIGHT BROWN TO YELLOW-BROWN POWDER
Originator
Flexin ,McNeil,US,1956
Uses
sweetener
Uses
Zoxazolamine is a centrally acting myorelaxant; formerly used as an antispasmodic and uricosuric. Used as a tool for assessing hepatic cytochrome P-450 activity in rodents.
Definition
ChEBI: Zoxazolamine is a benzoxazole.
Manufacturing Process
To a solution of 106 g (0.74 mol) of 2-amino-4-chlorophenol in 500 ml of
water containing 69 ml of concentrated hydrochloric acid (29.2 g, 0.8 mol) are
added 60.8 g (0.8 mol) of ammonium thiocyanate. The solution is placed in
an evaporating dish and heated on a steam bath for 5 hours. The solid which
results is then removed from the concentrated solution by filtration, washed
with a small amount of water and dried. The filtrate is placed in an
evaporating dish and heated on a water bath for 2 hours. At the end of this
time, the mixture is cooled, and the solid which precipitates out is removed by
filtration. Both solid products are 5-chloro-2-hydroxyphenylthiourea melting at
157°C, and may be combined. The calculated N content for C 7 H 7 ClN 2 OS is
13.8; that found is 13.6.
To a solution of 10 g (0.05 mol) of 2-hydroxy-5-chlorophenylthiourea in 50 ml
of methanol is added a solution of 11 g (0.04 mol) of ferric chloride
hexahydrate in 50 ml of methanol. The initial purple-red color changes in a
few minutes to amber. After stirring for one half hour, the solution is treated
with 16.5 ml of 57% ammonium hydroxide solution (0.24 mol). A brown,
flocculent precipitate of ferric sulfide appears. The mixture is then refluxed
with stirring for one hour, cooled and centrifuged. The centrifugate is
evaporated to dryness, and the residue is shaken with ether and water to
separate the organic material from the ammonium chloride. The ether layer is
extracted three times with 25 ml portions of 1 N hydrochloric acid. The acid
solution is then poured into excess ammonium hydroxide, and the resulting
solid collected, washed with water and dried. This gives a light tan solid
melting at 183°C to 185°. The material is then dissolved in 25 ml of acetone
and 50 ml of benzene are added. After treatment of the solution with
activated charcoal, the light yellow solution is evaporated to 25 ml and cooled.
The white crystals of 2-amino-5-chlorobenzoxazole which separate melt at
185°C to 186°C.
Therapeutic Function
Muscle relaxant, Uricosuric
Zoxazolamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Zoxazolamine manufacturers
- Product
- Zoxazolamine 61-80-3
- Price
- US $0.00/gram
- Min. Order
- 1gram
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2022-02-17
- Product
- Zoxazolamine 61-80-3
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10TON
- Release date
- 2018-12-18