Zoxazolamine

ChemicalBook > CAS DataBase List > Zoxazolamine

Product Name: Zoxazolamine
CAS No.: 61-80-3
Chemical Name: Zoxazolamine
Synonyms: Zoxine;Flexin;Zoxamin;McN-485;Deflexol;Flexilon;usafma-12;NSC 24995;Contrazole;USAF ma-12
CBNumber: CB7464410
Molecular Formula: C7H5ClN2O
Formula Weight: 168.58
MOL File: 61-80-3.mol

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Zoxazolamine Property

Melting point:: 181-184 °C(lit.)
Boiling point:: 316.8±34.0 °C(Predicted)
Density: 1.4369 (rough estimate)
refractive index: 1.5618 (estimate)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO, Methanol
pka: 0.73±0.10(Predicted)
form: Powder
color: Light brown to yellow-brown
Merck: 13,10249
CAS DataBase Reference: 61-80-3(CAS DataBase Reference)
NIST Chemistry Reference: Zoxazolamine(61-80-3)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: DM4550000
HS Code: 29349990
Toxicity: LD50 in mice, rats (mg/kg): 376, 102 i.p.; 678, 730 orally (Cain, Roszkowski)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A45807
Product name: 2-Amino-5-chlorobenzoxazole
Purity: 97%
Packaging: 5g
Price: $188
Updated: 2024/03/01

Sigma-Aldrich

Product number: A45807
Product name: 2-Amino-5-chlorobenzoxazole
Purity: 97%
Packaging: 1g
Price: $58.7
Updated: 2023/06/20

Cayman Chemical

Product number: 17565
Product name: Zoxazolamine
Purity: ≥98%
Packaging: 1g
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17565
Product name: Zoxazolamine
Purity: ≥98%
Packaging: 5g
Price: $109
Updated: 2024/03/01

Sigma-Aldrich

Product number: A45807
Product name: 2-Amino-5-chlorobenzoxazole
Purity: 97%
Packaging: 25g
Price: $572
Updated: 2024/03/01

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Zoxazolamine Chemical Properties,Usage,Production

Chemical Properties

LIGHT BROWN TO YELLOW-BROWN POWDER

Originator

Flexin ,McNeil,US,1956

Uses

sweetener

Uses

Zoxazolamine is a centrally acting myorelaxant; formerly used as an antispasmodic and uricosuric. Used as a tool for assessing hepatic cytochrome P-450 activity in rodents.

Definition

ChEBI: Zoxazolamine is a benzoxazole.

Manufacturing Process

To a solution of 106 g (0.74 mol) of 2-amino-4-chlorophenol in 500 ml of water containing 69 ml of concentrated hydrochloric acid (29.2 g, 0.8 mol) are added 60.8 g (0.8 mol) of ammonium thiocyanate. The solution is placed in an evaporating dish and heated on a steam bath for 5 hours. The solid which results is then removed from the concentrated solution by filtration, washed with a small amount of water and dried. The filtrate is placed in an evaporating dish and heated on a water bath for 2 hours. At the end of this time, the mixture is cooled, and the solid which precipitates out is removed by filtration. Both solid products are 5-chloro-2-hydroxyphenylthiourea melting at 157°C, and may be combined. The calculated N content for C 7 H 7 ClN 2 OS is 13.8; that found is 13.6.
To a solution of 10 g (0.05 mol) of 2-hydroxy-5-chlorophenylthiourea in 50 ml of methanol is added a solution of 11 g (0.04 mol) of ferric chloride hexahydrate in 50 ml of methanol. The initial purple-red color changes in a few minutes to amber. After stirring for one half hour, the solution is treated with 16.5 ml of 57% ammonium hydroxide solution (0.24 mol). A brown, flocculent precipitate of ferric sulfide appears. The mixture is then refluxed with stirring for one hour, cooled and centrifuged. The centrifugate is evaporated to dryness, and the residue is shaken with ether and water to separate the organic material from the ammonium chloride. The ether layer is extracted three times with 25 ml portions of 1 N hydrochloric acid. The acid solution is then poured into excess ammonium hydroxide, and the resulting solid collected, washed with water and dried. This gives a light tan solid melting at 183°C to 185°. The material is then dissolved in 25 ml of acetone and 50 ml of benzene are added. After treatment of the solution with activated charcoal, the light yellow solution is evaporated to 25 ml and cooled. The white crystals of 2-amino-5-chlorobenzoxazole which separate melt at 185°C to 186°C.

Therapeutic Function

Muscle relaxant, Uricosuric

Zoxazolamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Zoxazolamine manufacturers

Zhejiang J&C Biological Technology Co.,Limited

Product: Zoxazolamine 61-80-3
Price: US $0.00/gram
Min. Order: 1gram
Purity: 99%
Supply Ability: 10kg
Release date: 2022-02-17

Career Henan Chemical Co

Product: Zoxazolamine 61-80-3
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10TON
Release date: 2018-12-18

61-80-3, ZoxazolamineRelated Search:

1,3-Bis(aminomethyl)benzene o-Phenylenediamine Glycine 3-Aminophenol EC 2.6.1.2 Chlorphenamine maleate 2-Amino-5-chlorobenzonitrile 6-Aminocaproic acid 2-Benzoxazolinone Benzoxazole Acetaminophen Triclabendazole p-Phenylenediamine 2-Amino-5-chlorobenzoic acid m-Phenylenediamine Oxazole-2-amine Tris(hydroxymethyl)aminomethane ALTRENOGEST

2-AMINO-5-CHLOROBENZOXAZOLE

usafma-12

Zoxamin

Zoxine

TIMTEC-BB SBB003874

ZOXAZOLAMINE

2-Amino-5-chlorobenzoxazole,97%

2-Amino-5-chlorobenzoxazoleZoxazolamine

5-chlorobenzo[d]oxazol-2-aMine

2-amino-5-chloro-benzoxazol

2-Benzoxazolamine, 5-chloro-

5-Chloro-1,3-benzoxazol-2-amine

5-Chloro-2-benzoxazolamine

Benzoxazole, 2-amino-5-chloro-

Contrazole

Deflexol

Flexilon

Flexin

McN-485

USAF ma-12

2-Benzoxazolamine, 5-chloro- (9CI)

NSC 24995

(5-chloro-1,3-benzoxazol-2-yl)amine

Zossazolamina [DCIT]

61-80-3

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