2-Amino-5-chlorobenzoic acid
- Product Name
- 2-Amino-5-chlorobenzoic acid
- CAS No.
- 635-21-2
- Chemical Name
- 2-Amino-5-chlorobenzoic acid
- Synonyms
- 5-CHLOROANTHRANILIC ACID;2-CARBOXY-4-CHLOROANILINE;NSC 404157;2-Amino-5-chL;RARECHEM AL BO 0288;5-Chloranthranilsure;OTAVA-BB BB7020040772;5-Chloro-2-amino acid;Anthranilic acid, 5-chloro-;2-amino-5-chloro-benzoicaci
- CBNumber
- CB0107619
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 635-21-2.mol
2-Amino-5-chlorobenzoic acid Property
- Melting point:
- 204-206 °C (dec.) (lit.)
- Boiling point:
- 250°C (rough estimate)
- Density
- 1.3246 (rough estimate)
- refractive index
- 1.5560 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.57±0.10(Predicted)
- color
- White to Pale Grey
- Water Solubility
- Soluble in water.
- BRN
- 639027
- Major Application
- peptide synthesis
- InChI
- 1S/C7H6ClNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11)
- InChIKey
- IFXKXCLVKQVVDI-UHFFFAOYSA-N
- SMILES
- Nc1ccc(Cl)cc1C(O)=O
- CAS DataBase Reference
- 635-21-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzoic acid, 2-amino-5-chloro-(635-21-2)
- EPA Substance Registry System
- Benzoic acid, 2-amino-5-chloro- (635-21-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-37/38-36
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- TSCA
- TSCA listed
- HS Code
- 29224999
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 378046
- Product name
- 2-Amino-5-chlorobenzoic acid
- Purity
- 90%, technical grade
- Packaging
- 25g
- Price
- $77.3
- Updated
- 2025/07/31
- Product number
- A45475
- Product name
- 2-Amino-5-chlorobenzoic acid
- Purity
- 98%
- Packaging
- 10g
- Price
- $185
- Updated
- 2023/06/20
- Product number
- A0665
- Product name
- 5-Chloroanthranilic Acid
- Purity
- >99.0%(T)
- Packaging
- 5g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- A0665
- Product name
- 5-Chloroanthranilic Acid
- Purity
- >99.0%(T)
- Packaging
- 25g
- Price
- $89
- Updated
- 2025/07/31
- Product number
- C364400
- Product name
- 5-Chloroanthranilic Acid
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
2-Amino-5-chlorobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
White to light yellow crystal powder
Uses
2-Amino-5-chlorobenzoic acid is used in the preparation of disease-modifying antirheumatic drugs (DMARDs). Also used to produce 6-chloro-3H-quinazolin-4-one at temperature of 180°C.
Uses
2-Amino-5-chlorobenzoic acid is a chlorinated derivative of antharilic acid,it is a metabolite of the pesticide Chlordimeform and it is used in the preparation of disease-modifying antirheumatic drugs (DMARDs).
Uses
5-Chloroanthranilic Acid is a chlorinated derivative of anthranilic acid. 5-Chloroanthranilic Acid is a metabolite of the pesticide Chlordimeform. 5-Chloroanthranilic Acid is used in the preparation o f disease-modifying antirheumatic drugs (DMARDs).
Definition
ChEBI: 2-amino-5-chlorobenzoic acid is a member of the class of chlorobenzoic acids that is benzoic acid in which the ring hydrogens at positions 2 and 5 are replaced by amino and chloro groups, respectively. It is an aminobenzoic acid, a member of monochlorobenzenes and a chlorobenzoic acid.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
2516-95-2
635-21-2
General procedure for the synthesis of 2-amino-5-chlorobenzoic acid from 5-chloro-2-nitrobenzoic acid: active Raney nickel (2 g) was added to the reaction flask, followed by the addition of an ethanol solution of 5-chloro-2-nitrobenzoic acid (20 g, 110 mmol). The reaction mixture was stirred at room temperature in a hydrogen atmosphere overnight. Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to give 16 g of white solid product (96% yield). The product was characterized by 1H NMR (DMSO-d6): δ 6.77 (d, J = 8.9 Hz, 1H), 7.24 (dd, J = 2.9, 8.9 Hz, 1H), 7.62 (d, J = 2.9 Hz, 1H), 8.7 (br, 3H); EIMS: 170 (M-H).
References
[1] Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 1, p. 86 - 109
[2] Patent: WO2004/74218, 2004, A2. Location in patent: Page 115-116
[3] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 12, p. 2801 - 2809
[4] Chemical Biology and Drug Design, 2016, p. 710 - 723
[5] Zhurnal Obshchei Khimii, 1938, vol. 8, p. 1797,1801
2-Amino-5-chlorobenzoic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Amino-5-chlorobenzoic acid manufacturers
- Product
- 2-Amino-5-chlorobenzoic acid 635-21-2
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-08-08
- Product
- 2-Amino-5-chlorobenzoic acid 635-21-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-04
- Product
- 2-Amino-5-chlorobenzoic acid 635-21-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10