Melitracen
- Product Name
- Melitracen
- CAS No.
- 5118-29-6
- Chemical Name
- Melitracen
- Synonyms
- N-7001;Dixeran;U-24973;Trausban;Melitrace;melitracen;Brn 1980107;MELITRACENE;Einecs 225-858-5;Melitracen USP/EP/BP
- CBNumber
- CB7909593
- Molecular Formula
- C21H25N
- Formula Weight
- 291.43
- MOL File
- 5118-29-6.mol
Melitracen Property
- Boiling point:
- 423.43°C (rough estimate)
- Density
- 0.9801 (rough estimate)
- refractive index
- 1.4900 (estimate)
- pka
- 9.18±0.28(Predicted)
- NIST Chemistry Reference
- 1-Propanamine, 3-(10,10-dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-(5118-29-6)
N-Bromosuccinimide Price
- Product number
- API0007908
- Product name
- MELITRACEN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.37
- Updated
- 2021/12/16
- Product number
- 2810B
- Product name
- Melitracen
- Packaging
- 10mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 2810B
- Product name
- Melitracen
- Packaging
- 100mg
- Price
- $295
- Updated
- 2021/12/16
Melitracen Chemical Properties,Usage,Production
Originator
Trausabun,Lusofarma,W. Germany,1965
Uses
Antidepressant.
Definition
ChEBI: Melitracen is a member of anthracenes.
Manufacturing Process
24 g of 2-o-benzoylphenylpropanol-2 (MP 116°C) were dissolved in 250 ml of anhydrous ether and the resulting solution was added dropwise while stirring to a suspension of 0.22 mol of dimethylaminopropylmagnesium chloride in 100 ml of ether. The reaction mixture was refluxed for one hour on a steam bath, and water and dilute hydrochloric acid were added until the reaction was pH 4-5. The aqueous phase was separated and 60 ml of concentrated aqueous ammonia were added. The mixture was extracted with ether, and the ether phase was separated, dried and evaporated in a steam bath. The residue was dissolved in hot petroleum ether and the solution left standing to cool for some time, whereupon 4-dimethylamino-1-phenyl-1-[2-(2-hydroxy-2- propyl)phenyl]-butanol-1 crystallized out as white crystals which were sucked off. After drying they melted at 88°C to 90°C.
10 g of this compound were cautiously dissolved in 50 ml of concentrated
sulfuric acid under cooling and the mixture was kept at room temperature for
24 hours, whereupon the reaction mixture was poured into 200 g of finely
crushed ice, and concentrated aqueous ammonia was added to about pH 9,
whereupon the oil which separated out was extracted with ether. The ether
phase was separated, dried and the ether evaporated on a steam bath. The
residue was dissolved in 20 ml of acetone and the solution neutralized with a
solution of dry hydrogen chloride in ether. The white crystals of 9-γdimethylaminopropylidene-10,10-dimethyl-9,10-dihydroanthracene
hydrochloride which separated out was filtered off and dried. Yield 9 g. MP
245°C to 247°C.
Therapeutic Function
Antidepressant
Melitracen Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Melitracen manufacturers
- Product
- Melitracen 5118-29-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-26
- Product
- Melitracen 5118-29-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-17