ChemicalBook > CAS DataBase List > 1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride

1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride

Product Name
1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride
CAS No.
5424-37-3
Chemical Name
1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride
Synonyms
Surfen;Surfen (NSC-12155);Surfen dihydrochloride;NSC-12155 (surfen hydrate);Aminoquinuride hydrochloride;Aminokinuride dihydrochloride;Aminoquinuride dihydrochloride;Aminoquincarbamide dihydrochloride;1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride;1,3-bis(4-amino-2-methylquinolin-6-yl)urea, dihydrochloride
CBNumber
CB7922378
Molecular Formula
C21H22Cl2N6O
Formula Weight
445.34498
MOL File
5424-37-3.mol
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1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
Off-white to gray
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
6634
Product name
Surfen
Purity
≥98%(HPLC)
Packaging
5
Price
$104
Updated
2021/12/16
Tocris
Product number
6634
Product name
Surfen
Purity
≥98%(HPLC)
Packaging
25
Price
$405
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139214
Product name
Surfen
Packaging
50mg
Price
$437.5
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0308350
Product name
1,3-BIS(4-AMINO-2-METHYL-6-QUINOLYL)UREA DIHYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$497.09
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139214
Product name
Surfen
Packaging
10mg
Price
$125
Updated
2021/12/16
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1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride Chemical Properties,Usage,Production

Uses

Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].

IC 50

FGFR2: 5 μM (IC50); HSV-1

storage

Store at -20°C

References

[1] Schuksz M, et al. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80. DOI:10.1073/pnas.0805862105

1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride Suppliers

China 19 United Kingdom 1 United States 2 Global 22
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58

5424-37-3, 1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochlorideRelated Search:

6-Aminoquinoline 4,6-DIAMINO-2-METHYL-QUINOLINE 1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride 1,3-di-6-quinolylurea Aminoquinuride 6-AMINOQUINOLINE HYDROCHLORIDE

  • Aminoquinuride hydrochloride
  • Aminoquincarbamide dihydrochloride
  • NSC-12155 (surfen hydrate)
  • 1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride
  • Surfen
  • Surfen dihydrochloride
  • Surfen (NSC-12155)
  • 1,3-bis(4-amino-2-methylquinolin-6-yl)urea, dihydrochloride
  • Aminoquinuride dihydrochloride
  • Aminokinuride dihydrochloride
  • Aminokinuride dihydrochloride|||Aminoquinuride dihydrochloride|||NSC-12155|||Aminokinuride 2HCl|||Aminoquinuride 2HCl
  • 5424-37-3