1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol

Product Name: 1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol
CAS No.: 80879-63-6
Chemical Name: 1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol
Synonyms: MKC-542;BAY-o-1248;Emiglitate;1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol;1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol USP/EP/BP;4-[2-[(2R,3R,4R,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)piperidino]ethoxy]benzoic acid ethyl ester;Benzoic acid, 4-[2-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]ethoxy]-, ethyl ester
CBNumber: CB7924534
Molecular Formula: C17H25NO7
Formula Weight: 355.38
MOL File: 80879-63-6.mol

More

Less

1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol Property

Boiling point:: 580.2±50.0 °C(Predicted)
Density: 1.328±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 13.68±0.70(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0011315
Product name: EMIGLITATE
Purity: 95.00%
Packaging: 5MG
Price: $503.92
Updated: 2021/12/16

More

Less

1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol Chemical Properties,Usage,Production

Description

Emiglitate (BAY O 1248), another deoxynojirimycin analogue is characterized by at least five-fold higher inhibitory potency than acarbose and additionally shows a long-lasting inhibitory effect. In animal studies emiglitate was still active up to 17 h after a single oral administration due to its pharmacokinetic behavior (formation of an active metabolite). Both miglitol and emiglitate differ in their pharmacokinetic behavior from acarbose, which is poorly absorbed (1 – 2 %). The deoxynojirimycin derivatives are structurally related to monosaccharides and will be absorbed in the jejunum.

Uses

Emiglitate (BAY o 1248) is a potent, selective and competitive inhibitor of α-glucoside hydrolase.

in vivo

In fasted rats, emiglitate inducec a significant, dose-dependent increase of hepatic glycogen concentrations. The increase in hepatic glycogen is due to lysosomal storage of glycogen only. Emiglitate in the amount of 5 mg/kg b.wt. does not induce significant changes either of glycogen concentrations or at the EM-level^[2].

References

[1] Mosén H, et al. Nitric oxide inhibits, and carbon monoxide activates, islet acid alpha-glucoside hydrolase activitiesin parallel with glucose-stimulated insulin secretion. J Endocrinol. 2006 Sep;190(3):681-93. DOI:10.1677/joe.1.06890
[2] Lembcke B, et al. Lysosomal storage of glycogen as a sequel of alpha-glucosidase inhibition by the absorbed deoxynojirimycin derivative emiglitate (BAYo1248). A drug-induced pattern of hepatic glycogen storage mimicking Pompe's disease (glycogenosis type II). Res Exp Med (Berl). 1991;191(6):389-404. DOI:10.1007/BF02576694

1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol Suppliers

China 10 United States 4 Global 14

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 8025
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19962
Advantage: 58

Hu Bei Jiutian Bio-medical Technology CO.,Ltd

Tel: 027-88013699 17354350817
Email: Ryan@jiutian-bio.com
Country: China
ProdList: 5949
Advantage: 58

80879-63-6, 1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol Related Search:

Repaglinide Miglitol N-METHYL-1-DEOXYNOJIRIMYCIN 4-[2-(1-Piperidinyl)ethoxy]benzaldehyde 1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol 1-Deoxynojirimycin N,N-BIS(2-HYDROXYETHYL)ISOPROPANOLAMINE DIETHANOL PROPANOLAMINE 4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE 4-(2-(DIETHYLAMINO)-ETHOXY)-BENZALDEHYDE 4-HYDROXY-1-PIPERIDINEETHANOL 96 1,5-DIDEOXY-1,5-IMINO-XYLITOL trans-3,4-Dihydroxypiperidine 4-(2-piperdinylethoxy)benzoic acid hydrochloride [4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]METHANOL 4-(2-AMINOETHOXY)BENZOIC ACID

1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol

4-[2-[(2R,3R,4R,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)piperidino]ethoxy]benzoic acid ethyl ester

BAY-o-1248

MKC-542

Emiglitate

Benzoic acid, 4-[2-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]ethoxy]-, ethyl ester

1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol USP/EP/BP

80879-63-6