prednimustine
- Product Name
- prednimustine
- CAS No.
- 29069-24-7
- Chemical Name
- prednimustine
- Synonyms
- LEO-1031;Sterecyt;Stereocyt;NSC 171345;NSC-134087;Prednimustin;prednimustine;prednimustine USP/EP/BP;HFVNWDWLWUCIHC-GUPDPFMOSA-N;Prednisolone chloraMbucil ester
- CBNumber
- CB7933444
- Molecular Formula
- C35H45Cl2NO6
- Formula Weight
- 646.64
- MOL File
- 29069-24-7.mol
prednimustine Property
- Melting point:
- 163-164°
- alpha
- D24 +92.9° (c = 1.06 in chloroform)
- Boiling point:
- 791.5±60.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- pka
- 12.32±0.70(Predicted)
- IARC
- 3 (Vol. 50) 1990
Safety
- Hazardous Substances Data
- 29069-24-7(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- API0012322
- Product name
- PREDNIMUSTINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.74
- Updated
- 2021/12/16
prednimustine Chemical Properties,Usage,Production
Originator
Stereocyt, Bellon ,France ,1978
Uses
Antineoplastic.
Definition
ChEBI: Prednimustine is a corticosteroid hormone.
Manufacturing Process
p-[N-bis(β-chloroethyl)amino] phenyl butyric acid was dissolved in a mixture of 150 ml dry benzene and 8.04 ml dry pyridine. The solution was cooled in an ice bath, and a solution of thionyl chloride in 30 ml dry benzene was slowly added with stirring under anhydrous conditions.
The reaction mixture was then kept at room temperature for 1 hour and thereafter poured into a mixture of 5.0 N HCl and crushed ice. The benzene solution was immediately washed with water, with cold 1.0 N NaHCO3 and finally with cold water. After drying over anhydrous sodium sulfate, the benzene was removed in vacuo. The residue is the p-[N-bis(βchloroethyl)amino]phenyl butyric anhydride which could be used without any further purification.
To a solution of 42.0 g of p-[N-bis(β-chloroethyl)amino]phenyl butyric anhydride in 500 ml dry pyridine was added 24.4 g of prednisolone. The reaction mixture was kept at room temperature for 24 hours under anhydrous condition. It was then poured into a mixture of concentrated HCl and crushed ice and extracted with ether-ethyl acetate (1:1).
The organic phase was washed several times with cold 1.0 N K2CO3 and finallywater. After drying over CaCl2 the solvent was removed in vacuo.
The residue is prednisolone 21-[4'-[p-bis(β-chloroethyl)amino]phenyl]butyrate which after crystallization from methanol/water had a melting point of 163°C to 164°C.
Therapeutic Function
Cancer chemotherapy
prednimustine Preparation Products And Raw materials
Raw materials
Preparation Products
prednimustine Suppliers
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- 1-(800)-881-8210
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- 615-250-9817
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- Country
- United States
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View Lastest Price from prednimustine manufacturers
- Product
- prednimustine 29069-24-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-05