N-(3-chloropropyl)dibutylamine

Product Name: N-(3-chloropropyl)dibutylamine
CAS No.: 36421-15-5
Chemical Name: N-(3-chloropropyl)dibutylamine
Synonyms: N-(3-ChL;NSC51133;Einecs 253-027-7;Dronedarone Intermediate 2;Dronedarone Intermediate 4;Dibutyl(3-chloropropyl)aMine;Dronedarone hydrochloride SM2;N-(3-chloropropyl)dibutylamine;1-Dibutylamino-3-chloropropane;1-Chloro-3-Dibutylaminopropane
CBNumber: CB7933606
Molecular Formula: C11H24ClN
Formula Weight: 205.77
MOL File: 36421-15-5.mol

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N-(3-chloropropyl)dibutylamine Property

Boiling point:: 118-130 °C(Press: 25 Torr)
Density: 0.899±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 9.39±0.50(Predicted)
form: liquid
color: Pale yellow
InChI: InChI=1S/C11H24ClN/c1-3-5-9-13(10-6-4-2)11-7-8-12/h3-11H2,1-2H3
InChIKey: ANLMKUQEPXRMGV-UHFFFAOYSA-N
SMILES: C(N(CCCC)CCCCl)CCC

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Safety

HS Code: 2921199990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H350May cause cancer

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B694415
Product name: N-Butyl-N-(3-chloropropyl)butan-1-amine
Packaging: 100g
Price: $195
Updated: 2021/12/16

ChemScene

Product number: CS-M0185
Product name: N-Butyl-N-(3-chloropropyl)butan-1-amine
Purity: 98.19%
Packaging: 500g
Price: $277
Updated: 2021/12/16

AK Scientific

Product number: 4622AB
Product name: N-(3-Chloropropyl)dibutylamine
Packaging: 1g
Price: $21
Updated: 2021/12/16

ChemScene

Product number: CS-M0185
Product name: N-Butyl-N-(3-chloropropyl)butan-1-amine
Purity: 98.19%
Packaging: 100g
Price: $79
Updated: 2021/12/16

Matrix Scientific

Product number: 092429
Product name: N-Butyl-N-(3-chloropropyl)butan-1-amine
Purity: 95+%
Packaging: 5g
Price: $95
Updated: 2021/12/16

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N-(3-chloropropyl)dibutylamine Chemical Properties,Usage,Production

Uses

N-Butyl-N-(3-chloropropyl)butan-1-amine acts as a reagent in the process for the production of dronedarone hydrochloride, an antiarrhythmia drug. Impurity of Butoprozine which is an antiarrhythmic drug.

Synthesis

2050-51-3

36421-15-5

General procedure for the synthesis of N-(3-chloropropyl)dibutylamine from 3-(dibutylamino)propan-1-ol: 3-(dibutylamino)propan-1-ol (2.230 mmol, 0.418 g) was dissolved in chloroform (5 mL), and thionyl chloride (4.460 mmol, 0.328 mL) was slowly added via syringe. The reaction mixture was stirred under reflux conditions for 7 hours. After completion of the reaction, the reaction mixture was diluted with water and dichloromethane and potassium carbonate (1.2 g) was added. The organic layer was washed sequentially with saturated aqueous sodium bicarbonate (5 mL) and water (5 mL). The organic layer was dried with anhydrous magnesium sulfate, filtered, and the solvent was removed in vacuum to afford N-(3-chloropropyl)dibutylamine as a yellow oil (0.430 g, 94% yield).1H NMR (400 MHz, CDCl3) δ 3.62 (t, J = 6.5 Hz, 1H), 2.55 (t, J = 6.8 Hz, 1H), 2.40 (t, 2H) 1.89 (qi, 1H), 1.48-1.36 (m, 2H), 1.36-1.26 (m, 2H), 0.93 (t, J = 7.3 Hz, 3H).13C NMR (101 MHz, CDCl3) δ 54.02, 51.06, 43.45, 30.61, 29.43, 20.67, 14.05. HRMS (EI+): m/z C11H24NCl calculated value: 205.1597, measured value: 205.1596.

References

[1] Chem, 2018, vol. 4, # 3, p. 522 - 532
[2] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 8, p. 1149 - 1153
[3] Journal of the American Chemical Society, 1945, vol. 67, p. 1416,1417
[4] Journal of the American Chemical Society, 1941, vol. 63, p. 2435
[5] Journal of the American Chemical Society, 1945, vol. 67, p. 1416,1417

N-(3-chloropropyl)dibutylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(3-chloropropyl)dibutylamine Suppliers

China 179 Germany 1 India 5 United States 8 Global 193

Shenyang NovPharm Technology Co., Ltd.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Chembest Research Laboratories Limited

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Energy Chemical

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Jia Xing Isenchem Co.,Ltd

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Adamas Reagent, Ltd.

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Shanghai Longsheng chemical Co.,Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

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XiaoGan ShenYuan ChemPharm co,ltd

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Syntechem Co.,Ltd

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View Lastest Price from N-(3-chloropropyl)dibutylamine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: N-(3-chloropropyl)dibutylamine 36421-15-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-08-01

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-(3-chloropropyl)dibutylamine 36421-15-5
Price: US $0.00/G
Min. Order: 500G
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-01

Hebei Zhuanglai Chemical Trading Co Ltd

Product: N-(3-chloropropyl)dibutylamine 36421-15-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-04

36421-15-5, N-(3-chloropropyl)dibutylamineRelated Search:

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Einecs 253-027-7

1-Dibutylamino-3-chloropropane

N-(3-chloropropyl)dibutylamine

NSC51133

1-Chloro-3-di-N-butylaminopropane

Dronedarone Hydrochloride IMpurity F

Dibutyl(3-chloropropyl)aMine

N-butyl-N-(3-chloropropyl)butan-1-aMine

N-(3-ChL

1-Butanamine,N-butyl-N-(3-chloropropyl)-

N-(3-Chloropropyl)dibutylamine CAS 36421-15-5

N-(3-Chloropropyl) dibutyl amine (NCA)

Dronedarone Intermediate 2

Dronedarone Intermediate 4

N-(3-Chloropropyl)Dibutylamine （ For Dronedarone ）

1-Chloro-3-Dibutylaminopropane

Dronedarone hydrochloride SM2

36421-15-5

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