(R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid

Product Name: (R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid
CAS No.: 129101-37-7
Chemical Name: (R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid
Synonyms: Nebilolol Impurity 33;Nebivololo intermediate 3;6-Fluorochromane-2-carboxylic acid;R）6-Fluorochromane-2-carboxylic acid;(R)-6-FluorochroMan-2-carboxylic acid;(2R)-6-Fluorochroman-2-carboxylic acid;(2R)-6-fluorochromane-2-carboxylic acid;(R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid;(2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid;2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2R)-
CBNumber: CB7946903
Molecular Formula: C10H9FO3
Formula Weight: 196.18
MOL File: 129101-37-7.mol

More

Less

(R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid Property

Boiling point:: 358.0±42.0 °C(Predicted)
Density: 1.364±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 3.05±0.20(Predicted)
form: solid
color: White
optical activity: Consistent with structure
InChI: InChI=1S/C10H9FO3/c11-7-2-4-8-6(5-7)1-3-9(14-8)10(12)13/h2,4-5,9H,1,3H2,(H,12,13)/t9-/m1/s1
InChIKey: ZNJANLXCXMVFFI-SECBINFHSA-N
SMILES: [C@@H]1(C(O)=O)OC2=CC=C(F)C=C2CC1

More

Less

Safety

HS Code: 2932990090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: F590955
Product name: (2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid
Packaging: 100mg
Price: $55
Updated: 2021/12/16

TRC

Product number: F590955
Product name: (2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid
Packaging: 250mg
Price: $115
Updated: 2021/12/16

TRC

Product number: F590955
Product name: (2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid
Packaging: 500mg
Price: $185
Updated: 2021/12/16

Apolloscientific

Product number: PC201114
Product name: (R)-6-Fluorochroman-2-carboxylicacid
Purity: 95+%
Packaging: 250mg
Price: $111
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H21-3-R0
Product name: (R)-6-Fluorochroman-2-carboxylicacid
Purity: 95.0%
Packaging: 250mg
Price: $122
Updated: 2021/12/16

More

Less

(R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid Chemical Properties,Usage,Production

Uses

(2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid is a useful reagent for organic synthesis.

Synthesis

129050-25-5

129101-37-7

GENERAL STEPS: To a stirred mixed solution of nebivolol impurity 35 (2a-f) in tetrahydrofuran (THF, 2 mL) and methanol (MeOH, 1 mL) was added slowly and dropwise 0.25 M aqueous lithium hydroxide (LiOH) solution (1.05 equiv.) at room temperature with continuous stirring for 2 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and subsequently acidified with dilute hydrochloric acid (HCl). The crude product was extracted with ethyl acetate (EtOAc), the organic phases were combined and dried over anhydrous magnesium sulfate (MgSO4). After filtration, the solvent was evaporated under reduced pressure to give the crude product. Further purification by n-hexane crystallization gave the target products 6a-f. 4.2.22 Synthesis of (R)-6-fluorochroman-2-carboxylic acid (6a): compound 6a (89 mg) was obtained in 96% yield by treating 2a (100 mg, 0.47 mmol) as raw material in the above general steps according to the method described in section 4.2.21. 1H NMR (δ, ppm): 6.88-6.80 (m, 2H), 6.75 (dd, 3J = 8.7, 4JH-F = 2.6, 1H), 4.74 (dd, 1H, J = 7.6, 3.5), 2.90-2.75 (m, 2H), 2.33 (m, 1H), 2.18 (m, 1H). 13C NMR (δ, ppm): 175.8, 157.2 (d, 1JC-F = 237.9), 148.9 (d, 4JC-F = 2.1), 122.3 (d, 3JC-F = 7.5), 117.8 (d, 3JC-F = 8.1), 115.4 (d, 2JC-F = 22.7), 114.5 (d, 2JC- F = 23.2), 73.2, 24.1, 23.5 (d, 4JC-F = 1.1). Spin: [α]D20 = -12.6 (c 1.0, DMF) {literature value [α]D20 = -13.4 (c 1.0, DMF)}. Enantiomeric excess (ee) > 99% was determined using a Chiralcel ODH column with n-hexane/2-propanol/trifluoroacetic acid = 90:10:0.5 as the mobile phase at a flow rate of 1.0 mL/min and retention times tR = 6.92 min (S) and 9.62 min (R). High resolution mass spectrometry (HRMS) calculated value of C10H9FO3 [M]+: 196.0530, measured value: 196.0531.

References

[1] Tetrahedron Asymmetry, 2015, vol. 26, # 17, p. 912 - 917
[2] Patent: KR2017/37154, 2017, A. Location in patent: Paragraph 0291-0293

(R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid Suppliers

Austria 1 China 56 India 5 United Kingdom 1 United States 6 Global 69

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

HangZhou YuHao Chemical Technology Co., Ltd.

Tel: 0571-82693216
Fax: 0571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 2028
Advantage: 58

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q2635253576
Fax: QQ3382968513
Email: hailey@shsendpharm.com
Country: China
ProdList: 2081
Advantage: 55

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 6059
Advantage: 65

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10110
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Witofly Chemical Co. ,Ltd.

Tel: 021-50630626 18964684208
Email: sales@witofly.com
Country: China
ProdList: 1606
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 14948
Advantage: 58

More

Less

View Lastest Price from (R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Nebivolol Impurity 33 129101-37-7
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-03-28

Career Henan Chemical Co

Product: (R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid 129101-37-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

129101-37-7, (R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid Related Search:

Tetrahydro-4H-pyran-4-one 3-(Trifluoromethyl)benzoic acid 2-(Trifluoromethyl)benzoic acid Benzoic acid Potassium hydrogen phthalate Fluorine Repaglinide 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid (R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid

(R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

Nebivololo intermediate 3

6-Fluorochromane-2-carboxylic acid

(R)-6-FluorochroMan-2-carboxylic acid

(2R)-6-Fluoro-2-[(2R)-oxiran-2-yl)-3,4-dihydro-2H – chromene (Isomer - B )

(2R)-6-fluorochromane-2-carboxylic acid

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2R)-

(2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

(2R)-6-Fluorochroman-2-carboxylic acid

R）6-Fluorochromane-2-carboxylic acid

Nebilolol Impurity 33

129101-37-7