Tenatoprazole sodium

Product Name: Tenatoprazole sodium
CAS No.: 335299-59-7
Chemical Name: Tenatoprazole sodium
Synonyms: Tenatoprazole sodium;Tenatoprazole sodium salt;5-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-imidazo[4,5-b]pyridine, sodium salt;Tentoprazole sodiumQ: What is Tentoprazole sodium Q: What is the CAS Number of Tentoprazole sodium Q: What is the storage condition of Tentoprazole sodium
CBNumber: CB7955237
Molecular Formula: C16H19N4NaO3S
Formula Weight: 370.4
MOL File: 335299-59-7.mol

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Tenatoprazole sodium Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Crysdot

Product number: CD31005010
Product name: Tenatoprazolesodiumsalt
Purity: 98%
Packaging: 1mg
Price: $279
Updated: 2021/12/16

Crysdot

Product number: CD31005010
Product name: Tenatoprazolesodiumsalt
Purity: 98%
Packaging: 5mg
Price: $558
Updated: 2021/12/16

Crysdot

Product number: CD31005010
Product name: Tenatoprazolesodiumsalt
Purity: 98%
Packaging: 10mg
Price: $949
Updated: 2021/12/16

Crysdot

Product number: CD31005010
Product name: Tenatoprazolesodiumsalt
Purity: 98%
Packaging: 25mg
Price: $1676
Updated: 2021/12/16

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Tenatoprazole sodium Chemical Properties,Usage,Production

Uses

Tenatoprazole sodium (TU-199 sodium) is a proton pump inhibitor; inhibits hog gastric H+/K+-ATPase with an IC50 of 6.2 μM.

in vivo

Tenatoprazole inhibits basal gastric acid secretion in pylorus-ligated rats in a dose-dependent manner (ED₅₀=4.2 mg/kg p.o.). In gastric fistula rats, tenatoprazole (2.5 and 5 mg/kg i.d.) also inhibits gastric acid secretion stimulated by histamine, carbachol or tetragastrin. Furthermore, tenatoprazole prevents the formation of water-immersion restraint stress-, pylorus ligation- and indomethacin-induced gastric lesions, and mepirizole-induced duodenal ulcer in rats^[1]. Maximum binding of tenatoprazole is 2.9 nmol/mg of the enzyme at 2 h after IV administration. The binding sites of tenatoprazole are in the TM5/6 region at Cys813 and Cys822. The bioavailability of tenatoprazole is two-fold greater in the (S)-tenatoprazole sodium salt hydrate form as compared to the free form in dogs^[2].

References

[1] Shin JM, et al. Characterization of the inhibitory activity of tenatoprazole on the gastric H+,K+ -ATPase in vitro and in vivo. Biochem Pharmacol. 2006 Mar 14;71(6):837-49. DOI:10.1016/j.bcp.2005.11.030
[2] https://www.ncbi.nlm.nih.gov/pubmed/16405921 DOI:10.1358/mf.1999.21.2.529238

Tenatoprazole sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Tenatoprazole sodium Suppliers

China 14 India 2 United States 2 Global 18

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Tentoprazole sodiumQ: What is Tentoprazole sodium Q: What is the CAS Number of Tentoprazole sodium Q: What is the storage condition of Tentoprazole sodium

5-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-imidazo[4,5-b]pyridine, sodium salt

335299-59-7