7-Bromo-5-chloro-1H-indazole
- Product Name
- 7-Bromo-5-chloro-1H-indazole
- CAS No.
- 875305-86-5
- Chemical Name
- 7-Bromo-5-chloro-1H-indazole
- Synonyms
- 7-Bromo-5-chloro-1H-indazole;1H-Indazole, 7-bromo-5-chloro-;7-Bromo-5-chloro-1H-indazole97%;7-Bromo-5-chloro-1H-indazole 97%;7-bromo-5-chloro-1H-indazole - [B25997]
- CBNumber
- CB7956951
- Molecular Formula
- C7H4BrClN2
- Formula Weight
- 231.48
- MOL File
- 875305-86-5.mol
7-Bromo-5-chloro-1H-indazole Property
- storage temp.
- Storage temp. 2-8°C
- form
- solid
- color
- gray
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B682433
- Product name
- 7-Bromo-5-chloro-1H-indazole
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 3H32-D-48
- Product name
- 7-Bromo-5-chloro-1H-indazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 3H32-D-48
- Product name
- 7-Bromo-5-chloro-1H-indazole
- Purity
- 97%
- Packaging
- 5G
- Price
- $373
- Updated
- 2021/12/16
- Product number
- 3H32-D-48
- Product name
- 7-Bromo-5-chloro-1H-indazole
- Purity
- 97%
- Packaging
- 10g
- Price
- $636
- Updated
- 2021/12/16
- Product number
- HCH0025333
- Product name
- 7-BROMO-5-CHLORO-1H-INDAZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $679.37
- Updated
- 2021/12/16
7-Bromo-5-chloro-1H-indazole Chemical Properties,Usage,Production
Synthesis
95-69-2
875305-86-5
The general procedure for the synthesis of 7-bromo-5-chloro-1H-indazole from 4-chloro-2-methylaniline was as follows: 2-bromo-4-chloro-6-methylaniline (13.2 g, 59.90 mmol) was suspended in 24% hydrochloric acid (40 mL). The stirred mixture was cooled to 0°C and a solution of sodium nitrite (4.54 g, 65.90 mmol) in water (10 mL) was added slowly and dropwise over 30 minutes. Subsequently, the mixture was warmed to about 50°C and the pH was adjusted with sodium acetate to 5. The mixture was maintained at 0°C and a solution of 2-methyl-2-propanethiol (6.8 mL, 59.9 mmol) in ethanol (40 mL) was added in batches over 30 minutes. After addition, stirring was continued at 0°C for 30 min, then the reaction mixture was poured into crushed ice and extracted with ethyl acetate (2×). The organic phases were combined, washed with brine (2×), dried over anhydrous sodium sulfate, filtered and concentrated. The resulting residue was dissolved in dimethyl sulfoxide (50 mL) and transferred to a solution of potassium tert-butoxide (53.7 g, 479 mmol) in dimethyl sulfoxide (200 mL) via cannula at 0°C. The residue was extracted with ethyl acetate (2×). The ice bath was removed and stirring was continued for 30 min. Subsequently, the reaction mixture was poured into a mixture of crushed ice (400 mL) and 10% hydrochloric acid (200 mL), a precipitate was precipitated and collected by filtration. The resulting solid was ground with hexane to give 7.5 g (54% yield) of brown powdery product.1H-NMR (CDCl3, 300 MHz) δ 7.97 (s, 1H), 7.60 (s, 1H), 7.44 (s, 1H). MS: 232.90 (MH)+.
References
[1] Patent: US2009/18132, 2009, A1. Location in patent: Page/Page column 56
7-Bromo-5-chloro-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
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