4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine

Product Name: 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine
CAS No.: 123066-64-8
Chemical Name: 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine
Synonyms: CRAC 2;CRAC intermediate 2;CRAC intermediate 2, 10 mM in DMSO;4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]aniline;4-(3,5-Bis(trifluoroMethyl)-1H-pyrazol-1-yl)aniline;4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine;Benzenamine, 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-;CRAC intermediate-2,Ca2+ release-activated Ca2+ channels,CRAC intermediate2,Inhibitor,CRAC Channel,CRAC intermediate 2,inhibit,Calcium release-activated channels
CBNumber: CB7958425
Molecular Formula: C11H7F6N3
Formula Weight: 295.18
MOL File: 123066-64-8.mol

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4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine Property

Melting point:: 140-142 °C
Boiling point:: 298.4±40.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO : ≥ 52 mg/mL (176.16 mM)
form: Solid
pka: 2.65±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B586670
Product name: 4-(3,5-Bis(trifluoromethyl)-1h-pyrazol-1-yl)phenylamine
Packaging: 100mg
Price: $155
Updated: 2021/12/16

Matrix Scientific

Product number: 072257
Product name: 4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine
Purity: 95+%
Packaging: 1g
Price: $798
Updated: 2021/12/16

AK Scientific

Product number: X9549
Product name: 4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine
Packaging: 5g
Price: $968
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0121069
Product name: 4-(3,5-BIS(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL)PHENYLAMINE
Purity: 95.00%
Packaging: 250MG
Price: $984.06
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0121069
Product name: 4-(3,5-BIS(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL)PHENYLAMINE
Purity: 95.00%
Packaging: 1G
Price: $1455.3
Updated: 2021/12/16

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4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine Chemical Properties,Usage,Production

Uses

CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis, extracted from patent WO 2013059666A1.

Synthesis

123066-63-7

123066-64-8

Under hydrogen atmosphere, 1-(4-nitrophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (4.4 g, 13.5 mmol) was dissolved in EtOAc (44 mL) and Pd/C (1.3 g) was added. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was vacuum filtered through a diatomaceous earth pad and the filter cake was washed with EtOAc. The filtrate was concentrated under reduced pressure to afford 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-aniline (compound 13) as a light yellow solid (3.75 g, 12.7 mmol, 94% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3) and mass spectrometry (MS): 1H-NMR δ 7.22 (d, J=8.5 Hz, 2H), 7.00 (s, 1H), 6.72 (d, J=8.5 Hz, 2H); MS m/z: [M+H]+ 296.

References

[1] Journal of Organic Chemistry, 2011, vol. 76, # 16, p. 6657 - 6669
[2] Patent: WO2017/212414, 2017, A1. Location in patent: Page/Page column 43
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 16, p. 2975 - 2981

4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine manufacturers

Career Henan Chemical Co

Product: 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine 123066-64-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

123066-64-8, 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamineRelated Search:

2,3-Dichloro-5-(trifluoromethyl)pyridine 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride Inter-trifluoromethyl iodobenzene Trifluoromethanesulfonimide 1-(4-NITROPHENYL)-3,5-DI(TRIFLUOROMETHYL)-1H-PYRAZOLE 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine BTP2 N1-(4-[3,5-DI(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]PHENYL)-2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-PENTADECAFLUOROOCTANAMIDE 2-AZIDO-N-[4-(3,5-(BIS-TRIFLUOROMETHYL)PYRAZOL-1-YL)PHENYL] BENZAMIDE, [AZIDOANTHRANILIC ACID RING-3H]-

4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine

4-(3,5-Bis(trifluoroMethyl)-1H-pyrazol-1-yl)aniline

CRAC intermediate 2

4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]aniline

CRAC 2

Benzenamine, 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-

CRAC intermediate-2,Ca2+ release-activated Ca2+ channels,CRAC intermediate2,Inhibitor,CRAC Channel,CRAC intermediate 2,inhibit,Calcium release-activated channels

CRAC intermediate 2, 10 mM in DMSO

123066-64-8