2-methoxy-5-nitropyrimidine
- Product Name
- 2-methoxy-5-nitropyrimidine
- CAS No.
- 14001-69-5
- Chemical Name
- 2-methoxy-5-nitropyrimidine
- Synonyms
- 2-methoxy-5-nitropyrimidine;Pyrimidine, 2-methoxy-5-nitro-;2-methoxy-5-nitropyrimidine ISO 9001：2015 REACH
- CBNumber
- CB7966525
- Molecular Formula
- C5H5N3O3
- Formula Weight
- 155.11
- MOL File
- 14001-69-5.mol
2-methoxy-5-nitropyrimidine Property
- Melting point:
- 168-169 °C
- Boiling point:
- 305.3±34.0 °C(Predicted)
- Density
- 1.388±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -1.99±0.22(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M3080
- Product name
- 2-Methoxy-5-nitropyrimidine
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $109
- Updated
- 2025/07/31
- Product number
- M3080
- Product name
- 2-Methoxy-5-nitropyrimidine
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $326
- Updated
- 2025/07/31
- Product number
- M265783
- Product name
- 2-Methoxy-5-nitropyrimidine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- M265783
- Product name
- 2-Methoxy-5-nitropyrimidine
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 075207
- Product name
- 2-Methoxy-5-nitropyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $416
- Updated
- 2021/12/16
2-methoxy-5-nitropyrimidine Chemical Properties,Usage,Production
Synthesis
10320-42-0
124-41-4
14001-69-5
1. Synthesis of 2-methoxy-5-nitropyrimidine: 2-chloro-5-nitropyrimidine (0.486 g, 3.03 mmol) was added to a methanol (12 mL) solution of sodium methanolate (0.090 g sodium) and heated at reflux for 1 hour. After cooling, the reaction mixture was concentrated under vacuum, extracted with ethyl acetate and washed with water. The aqueous layer was then extracted with chloroform, the organic layers were combined, dried with sodium sulfate and concentrated to give 2-methoxy-5-nitropyrimidine in yellow powder form (0.347 g, 75% yield). 2. Synthesis of 5-amino-2-methoxypyrimidine: the above nitro compound (0.342g, 2.20mmol) was dissolved in methanol (20mL), 10% Pd/C (0.30g) was added, and stirred for 18 hours under a hydrogen atmosphere (25 inches/hour). The reaction mixture was filtered through diatomaceous earth and concentrated to give 5-amino-2-methoxypyrimidine (0.274 g, 100% yield) as colorless oil. 3. Synthesis of target compound: The above amino compound (0.274 g, 2.19 mmol) was dissolved in tetrahydrofuran (3 mL), 1.25 mL NaHMDS (2M THF solution) was added and stirred for 10 min. A THF (5 mL) solution of 1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-1H-benzimidazole (0.31 g, 0.78 mmol) was added and stirring was continued for 90 min. The reaction mixture was neutralized with acetic acid, diluted with water and extracted with ethyl acetate. The organic layer was washed with water and ammonia, dried and concentrated. Recrystallization from ethanol/dichloromethane gave the target compound (0.098 g, 26% yield).
References
[1] Patent: US2011/9405, 2011, A1. Location in patent: Page/Page column 55-56
[2] Journal of the American Chemical Society, 1942, vol. 64, p. 567,569,570
[3] Australian Journal of Chemistry, 1966, vol. 19, p. 2321,2326
[4] Patent: WO2005/3100, 2005, A2. Location in patent: Page 135
2-methoxy-5-nitropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-methoxy-5-nitropyrimidine manufacturers
- Product
- 2-methoxy-5-nitropyrimidine 14001-69-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-14
- Product
- 2-methoxy-5-nitropyrimidine 14001-69-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-12-18