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2-Methoxypyrimidin-5-amine

Product Name
2-Methoxypyrimidin-5-amine
CAS No.
56621-89-7
Chemical Name
2-Methoxypyrimidin-5-amine
Synonyms
2-Methoxy-5-pyriMidinaMine;2-METHOXYPYRIMIDIN-5-AMINE;5-Pyrimidinamine, 2-methoxy;5-Amino-2-methoxypyrimidine;2-methoxypyrimidine-5-amine;2-Methoxy-pyrimidin-5-ylamine;5-Pyrimidinamine, 2-methoxy- (9CI);2-Methoxypyrimidin-5-amine ISO 9001：2015 REACH;2-Methoxypyrimidin-5-amine, 5-Amino-2-methoxy-1,3-diazine
CBNumber
CB9332124
Molecular Formula
C5H7N3O
Formula Weight
125.13
MOL File
56621-89-7.mol
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2-Methoxypyrimidin-5-amine Property

Melting point:
119-120 °C(Solv: benzene (71-43-2))
Boiling point:
294.4±32.0 °C(Predicted)
Density 
1.224±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.49±0.22(Predicted)
Appearance
Yellow to brown Solid
InChI
InChI=1S/C5H7N3O/c1-9-5-7-2-4(6)3-8-5/h2-3H,6H2,1H3
InChIKey
HKHRENFWPKWVML-UHFFFAOYSA-N
SMILES
C1(OC)=NC=C(N)C=N1
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M332998
Product name
2-Methoxypyrimidin-5-amine
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
M332998
Product name
2-Methoxypyrimidin-5-amine
Packaging
500mg
Price
$155
Updated
2021/12/16
SynQuest Laboratories
Product number
4H30-1-X9
Product name
5-Amino-2-methoxypyrimidine
Purity
95%
Packaging
5G
Price
$316
Updated
2021/12/16
SynQuest Laboratories
Product number
4H30-1-X9
Product name
5-Amino-2-methoxypyrimidine
Purity
95%
Packaging
1g
Price
$79
Updated
2021/12/16
AK Scientific
Product number
W7025
Product name
5-Amino-2-methoxypyrimidine
Packaging
250mg
Price
$87
Updated
2021/12/16
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2-Methoxypyrimidin-5-amine Chemical Properties,Usage,Production

Synthesis

14001-69-5

56621-89-7

Example 40: Synthesis of 4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(2-methoxy-5-pyrimidinyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine The target compound was synthesized according to Method A. To a solution of sodium methanol (0.090 g sodium) in methanol (12 mL) was added 0.486 g (3.03 mmol) of 2-chloro-5-nitropyrimidine, and the mixture was heated under reflux conditions for 1 hour. After completion of the reaction, the mixture was cooled, concentrated in vacuum, extracted with ethyl acetate and washed with water. The aqueous layer was extracted with chloroform, the organic layers were combined, dried over anhydrous sodium sulfate and concentrated to give 0.347 g (75% yield) of 2-methoxy-5-nitropyrimidine as a yellow powder.1H NMR (CDCl3) δ 9.31 (s, 2H), 4.17 (s, 3H); LCMS (APCI+) m/z: 156 (MH+, 100%). 0.342 g (2.20 mmol) of the above nitro compound was dissolved in methanol (20 mL), 0.30 g of 10% Pd/C catalyst was added, and the reaction was stirred for 18 hr under a hydrogen atmosphere (25 in/hr). After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated to give 0.274 g (100% yield) of 5-amino-2-methoxypyrimidine as a colorless oil.1H NMR (DMSO-d6) δ 8.05 (s, 2H), 3.94 (s, 3H); LCMS (APCI+) m/z: 126 (MH+, 100%). 0.274 g (2.19 mmol) of the above amino compound was dissolved in tetrahydrofuran (3 mL), 1.25 mL of NaHMDS (2M THF solution) was added and stirred for 10 min. Then 0.31 g (0.78 mmol) of 1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-1H-benzimidazole solution in THF (5 mL) was added and stirring was continued for 90 minutes. After completion of the reaction, the reaction mixture was neutralized with acetic acid, diluted with water and extracted with ethyl acetate. The organic layer was washed sequentially with water and ammonia, dried and concentrated. Recrystallization by ethanol/dichloromethane gave 0.098 g (26% yield) of the target compound with melting point 255-258 °C.1H NMR (DMSO-d6) δ 10.07 (s, 1H), 8.88-8.74 (m, 2H), 8.15-7.42 (m, 3H), 6.97 (d, J = 8.0 Hz, 1H), 3.98 (s, 3H), 3.93 (s, 3H), 3.82-3.72 (m, 8H); Elemental Analysis Calculated Values C21H21F2N6O3: C, 52.0; H, 4.4; N, 26.0. Measured Values: C, 52.1; H, 4.5; N, 26.0%.

References

[1] Patent: US2011/9405, 2011, A1. Location in patent: Page/Page column 55-56

2-Methoxypyrimidin-5-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methoxypyrimidin-5-amine Suppliers

China 88 Europe 1 Germany 2 India 1 United Kingdom 2 United States 13 Global 107
Shanghai Jiezhen Pharmaceutical Technology Co., Ltd.
Tel
15995055116
Fax
815229059
Email
815229059@qq.com
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China
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
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jkinfo@jkchemical.com
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China
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PharmaBlock Sciences (Nanjing),Inc.
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025-86918202 4000255188
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86-025-86918232
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sales@pharmablock.com
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China
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5000
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Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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sales@chemreagents.com
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United States
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Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
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021-50795055
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sales@accelachem.com
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China
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11035
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PSN Pharmaceutical Technology Co., Ltd.
Tel
86-25-57062118
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86-25-57065896
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sales@jspsn.com
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China
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Tongchuang Pharma(Suzhou). Co., Ltd.
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0512-63263366 18912765016
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0512-6326 3366
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tongtf110@sina.com
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China
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Shanghai yirong biology science and technology co., ltd
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18049974220
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+86 (21) 51062076
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3060526242@qq.com
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China
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Chiba Pharmaceutical Science and technology Co, Ltd.
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0531-81313138 13066006660
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QQ: 3366077777
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chibapharm@foxmail.com
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China
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Wuhan TCASChem Technology Co., Ltd.
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027-86697669 13986148687
Fax
86-027-86697669
Email
sales@tcaschem.com
Country
China
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3991
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View Lastest Price from 2-Methoxypyrimidin-5-amine manufacturers

Dideu Industries Group Limited
Product
2-Methoxypyrimidin-5-amine 56621-89-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-10
Career Henan Chemical Co
Product
2-Methoxypyrimidin-5-amine 56621-89-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-07

56621-89-7, 2-Methoxypyrimidin-5-amineRelated Search:

5-Amino-2-methoxypyridine 4-Methoxyphenylacetic acid 4-Methoxybenzylchloride Bis(2-ethylhexyl)amine p-Anisidine Dibenzylamine p-Anisaldehyde Anisole (Trifluoromethoxy)benzene 3-Methoxybenzaldehyde 4-Methoxyphenylacetone Triallylamine 2-METHOXY-5-NITROPYRIMIDIN-4-AMINE 2-methoxypyrimidin-4-amine 6-CHLORO-5-METHOXYPYRIMIDIN-4-AMINE 6-METHOXYPYRIMIDIN-4-AMINE 4-FLUORO-6-METHOXYPYRIMIDIN-2-AMINE 2-methoxy-5-nitropyrimidine

  • 2-METHOXYPYRIMIDIN-5-AMINE
  • 5-Pyrimidinamine, 2-methoxy
  • 2-Methoxy-pyrimidin-5-ylamine
  • 5-Pyrimidinamine, 2-methoxy- (9CI)
  • 5-Amino-2-methoxypyrimidine
  • 2-Methoxypyrimidin-5-amine, 5-Amino-2-methoxy-1,3-diazine
  • 2-Methoxy-5-pyriMidinaMine
  • 2-methoxypyrimidine-5-amine
  • 2-Methoxypyrimidin-5-amine ISO 9001：2015 REACH
  • 56621-89-7
  • Amines
  • Pyrazines, Pyrimidines & Pyridazines
  • PYRIMIDINE
  • Heterocycle-Pyrimidine series