ChemicalBook > CAS DataBase List > 2-Methoxypyrimidin-5-amine

2-Methoxypyrimidin-5-amine

Product Name: 2-Methoxypyrimidin-5-amine
CAS No.: 56621-89-7
Chemical Name: 2-Methoxypyrimidin-5-amine
Synonyms: 2-Methoxy-5-pyriMidinaMine;2-METHOXYPYRIMIDIN-5-AMINE;5-Pyrimidinamine, 2-methoxy;5-Amino-2-methoxypyrimidine;2-methoxypyrimidine-5-amine;2-Methoxy-pyrimidin-5-ylamine;5-Pyrimidinamine, 2-methoxy- (9CI);2-Methoxypyrimidin-5-amine ISO 9001：2015 REACH;2-Methoxypyrimidin-5-amine, 5-Amino-2-methoxy-1,3-diazine
CBNumber: CB9332124
Molecular Formula: C5H7N3O
Formula Weight: 125.13
MOL File: 56621-89-7.mol

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2-Methoxypyrimidin-5-amine Property

Melting point:: 119-120 °C(Solv: benzene (71-43-2))
Boiling point:: 294.4±32.0 °C(Predicted)
Density: 1.224±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 2.49±0.22(Predicted)
Appearance: Yellow to brown Solid
InChI: InChI=1S/C5H7N3O/c1-9-5-7-2-4(6)3-8-5/h2-3H,6H2,1H3
InChIKey: HKHRENFWPKWVML-UHFFFAOYSA-N
SMILES: C1(OC)=NC=C(N)C=N1

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M332998
Product name: 2-Methoxypyrimidin-5-amine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: M332998
Product name: 2-Methoxypyrimidin-5-amine
Packaging: 500mg
Price: $155
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H30-1-X9
Product name: 5-Amino-2-methoxypyrimidine
Purity: 95%
Packaging: 250mg
Price: $28
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H30-1-X9
Product name: 5-Amino-2-methoxypyrimidine
Purity: 95%
Packaging: 1g
Price: $79
Updated: 2021/12/16

AK Scientific

Product number: W7025
Product name: 5-Amino-2-methoxypyrimidine
Packaging: 250mg
Price: $87
Updated: 2021/12/16

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2-Methoxypyrimidin-5-amine Chemical Properties,Usage,Production

Synthesis

14001-69-5

56621-89-7

Example 40: Synthesis of 4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(2-methoxy-5-pyrimidinyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine The target compound was synthesized according to Method A. To a solution of sodium methanol (0.090 g sodium) in methanol (12 mL) was added 0.486 g (3.03 mmol) of 2-chloro-5-nitropyrimidine, and the mixture was heated under reflux conditions for 1 hour. After completion of the reaction, the mixture was cooled, concentrated in vacuum, extracted with ethyl acetate and washed with water. The aqueous layer was extracted with chloroform, the organic layers were combined, dried over anhydrous sodium sulfate and concentrated to give 0.347 g (75% yield) of 2-methoxy-5-nitropyrimidine as a yellow powder.1H NMR (CDCl3) δ 9.31 (s, 2H), 4.17 (s, 3H); LCMS (APCI+) m/z: 156 (MH+, 100%). 0.342 g (2.20 mmol) of the above nitro compound was dissolved in methanol (20 mL), 0.30 g of 10% Pd/C catalyst was added, and the reaction was stirred for 18 hr under a hydrogen atmosphere (25 in/hr). After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated to give 0.274 g (100% yield) of 5-amino-2-methoxypyrimidine as a colorless oil.1H NMR (DMSO-d6) δ 8.05 (s, 2H), 3.94 (s, 3H); LCMS (APCI+) m/z: 126 (MH+, 100%). 0.274 g (2.19 mmol) of the above amino compound was dissolved in tetrahydrofuran (3 mL), 1.25 mL of NaHMDS (2M THF solution) was added and stirred for 10 min. Then 0.31 g (0.78 mmol) of 1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-1H-benzimidazole solution in THF (5 mL) was added and stirring was continued for 90 minutes. After completion of the reaction, the reaction mixture was neutralized with acetic acid, diluted with water and extracted with ethyl acetate. The organic layer was washed sequentially with water and ammonia, dried and concentrated. Recrystallization by ethanol/dichloromethane gave 0.098 g (26% yield) of the target compound with melting point 255-258 °C.1H NMR (DMSO-d6) δ 10.07 (s, 1H), 8.88-8.74 (m, 2H), 8.15-7.42 (m, 3H), 6.97 (d, J = 8.0 Hz, 1H), 3.98 (s, 3H), 3.93 (s, 3H), 3.82-3.72 (m, 8H); Elemental Analysis Calculated Values C21H21F2N6O3: C, 52.0; H, 4.4; N, 26.0. Measured Values: C, 52.1; H, 4.5; N, 26.0%.

References

[1] Patent: US2011/9405, 2011, A1. Location in patent: Page/Page column 55-56

2-Methoxypyrimidin-5-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Methoxypyrimidin-5-amine manufacturers

Dideu Industries Group Limited

Product: 2-Methoxypyrimidin-5-amine 56621-89-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-10

Career Henan Chemical Co

Product: 2-Methoxypyrimidin-5-amine 56621-89-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-07

56621-89-7, 2-Methoxypyrimidin-5-amineRelated Search:

5-Amino-2-methoxypyridine 4-Methoxyphenylacetic acid 4-Methoxybenzylchloride Bis(2-ethylhexyl)amine p-Anisidine Dibenzylamine p-Anisaldehyde Anisole (Trifluoromethoxy)benzene 3-Methoxybenzaldehyde 4-Methoxyphenylacetone Triallylamine 2-METHOXY-5-NITROPYRIMIDIN-4-AMINE 2-methoxypyrimidin-4-amine 6-CHLORO-5-METHOXYPYRIMIDIN-4-AMINE 6-METHOXYPYRIMIDIN-4-AMINE 4-FLUORO-6-METHOXYPYRIMIDIN-2-AMINE 2-methoxy-5-nitropyrimidine

2-METHOXYPYRIMIDIN-5-AMINE

5-Pyrimidinamine, 2-methoxy

2-Methoxy-pyrimidin-5-ylamine

5-Pyrimidinamine, 2-methoxy- (9CI)

5-Amino-2-methoxypyrimidine

2-Methoxypyrimidin-5-amine, 5-Amino-2-methoxy-1,3-diazine

2-Methoxy-5-pyriMidinaMine

2-methoxypyrimidine-5-amine

2-Methoxypyrimidin-5-amine ISO 9001：2015 REACH

56621-89-7

Amines

Pyrazines, Pyrimidines & Pyridazines

PYRIMIDINE

Heterocycle-Pyrimidine series