5-Methoxy-2-methyl benzeneboronic acid
- Product Name
- 5-Methoxy-2-methyl benzeneboronic acid
- CAS No.
- 617689-07-3
- Chemical Name
- 5-Methoxy-2-methyl benzeneboronic acid
- Synonyms
- (5-Methoxy-2-methylphenyl);2-Methyl-5-Methoxy-phenylboronic acid;5-Methoxy-2-methyl benzeneboronic acid;boronic acid, (5-methoxy-2-methylphenyl)-;Boronic acid, B-(5-methoxy-2-methylphenyl)-;(5-Methoxy-2-methylphenyl)boronic acid(contains varying amounts of Anhydride)
- CBNumber
- CB7969647
- Molecular Formula
- C8H11BO3
- Formula Weight
- 165.98
- MOL File
- Mol file
5-Methoxy-2-methyl benzeneboronic acid Property
- Boiling point:
- 334.9±52.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.18±0.58(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H320Causes eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M341448
- Product name
- (5-Methoxy-2-methylphenyl)boronicAcid
- Packaging
- 500mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 120045
- Product name
- (5-Methoxy-2-methylphenyl)boronic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $346
- Updated
- 2021/12/16
- Product number
- BOR0000717
- Product name
- 5-METHOXY-2-METHYLBENZENEBORONIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.95
- Updated
- 2021/12/16
- Product number
- BOR0000717
- Product name
- 5-METHOXY-2-METHYLBENZENEBORONIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $698.25
- Updated
- 2021/12/16
- Product number
- 120045
- Product name
- (5-Methoxy-2-methylphenyl)boronic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $864
- Updated
- 2021/12/16
5-Methoxy-2-methyl benzeneboronic acid Chemical Properties,Usage,Production
Uses
(5-Methoxy-2-methylphenyl)boronic Acid is used in preparation of Phenyl-substituted Imidazopyridine Amides useful in the treatment of cardiovascular and other disorders.
Synthesis
36942-56-0
617689-07-3
The general procedure for the synthesis of 5-methoxy-2-methylphenylboronic acid from 3-bromo-4-methylanisole was as follows: 2.5 M n-butyllithium (nBuLi, 1.8 mL, 4.5 mmol) was added slowly and dropwise over a period of 5 min to 2-bromo-4-methoxy-1-methylbenzene (750 mg, 3.73 mmol) in an anhydrous tetrahydrofuran (THF,) at -78 °C. 30 mL) solution. The reaction mixture was stirred at -78 °C for 20 min before adding anhydrous trimethylborate (0.62 g, 6 mmol). The reaction mixture was warmed to room temperature and kept for 2 hours. The reaction was quenched by addition of 2N hydrochloric acid (HCl, 1 mL). THF was removed by distillation under reduced pressure. the crude product was diluted with 2N HCl (100 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic phases were dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a light yellow solid product (0.43 g, 69% yield).
References
[1] Patent: US2005/245524, 2005, A1. Location in patent: Page/Page column 98-99
5-Methoxy-2-methyl benzeneboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Methoxy-2-methyl benzeneboronic acid manufacturers
- Product
- 5-Methoxy-2-methyl benzeneboronic acid 617689-07-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26