HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL

Product Name: HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL
CAS No.: 75614-89-0
Chemical Name: HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL
Synonyms: (R)()-α-Methylhistamine;(R)-(-)-α-Methylhistamine 2HCl;R-(?)-α-Methylhistamine hydrochloride;R-()-α-Methylhistamine (hydrochloride);HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL;R(-)-α-Methyl Histamine Dihydrochloride;(R)-1-(1H-Imidazol-4-yl)propan-2-amine dihydrochloride;(R)-2-(1H-Imidazol-4-yl)-1-methyl-ethylamine hydrochloride;R-(-)-2-(1H-Imidazol-4-yl)-1-methyl-ethylamine dihydrochloride;(R)()αMethylhistamine dihydrochloride,(R) ( ) α Methylhistamine dihydrochloride
CBNumber: CB7972858
Molecular Formula: C6H12ClN3
Formula Weight: 161.63
MOL File: 75614-89-0.mol

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HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL Property

Melting point:: 169-173°C
storage temp.: desiccated
solubility: H2O: soluble
form: Powder
color: white to off-white
optical activity: [α]22/D 4°, c = 0.8 in H2O(lit.)
Water Solubility: H2O: soluble
Sensitive: Hygroscopic
InChI: 1S/C6H11N3.2ClH/c1-5(7)2-6-3-8-4-9-6;;/h3-5H,2,7H2,1H3,(H,8,9);2*1H/t5-;;/m1../s1
InChIKey: IZHCNQFUWDFPCW-ZJIMSODOSA-N
SMILES: Cl.Cl.C[C@@H](N)Cc1c[nH]cn1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H128
Product name: (R)(?)-α-Methylhistamine dihydrochloride
Purity: solid, ≥98% (HPLC)
Packaging: 5mg
Price: $134
Updated: 2025/07/31

Sigma-Aldrich

Product number: H128
Product name: (R)(?)-α-Methylhistamine dihydrochloride
Purity: solid, ≥98% (HPLC)
Packaging: 25mg
Price: $536
Updated: 2025/07/31

Cayman Chemical

Product number: 25601
Product name: R-(?)-α-Methylhistamine (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 25601
Product name: R-(?)-α-Methylhistamine (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: H128
Product name: (R)(?)-α-Methylhistamine dihydrochloride
Purity: solid, ≥98% (HPLC)
Packaging: 100mg
Price: $1170
Updated: 2025/07/31

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HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL Chemical Properties,Usage,Production

Uses

R(-)-α-Methyl Histamine Dihydrochloride is a potent and selective H3 histamine receptor agonist that inhibits the synthesis and release of histamine (1,2,3,4). R(-)-α-Methyl Histamine Dihydrochloride is a blood-brain barrier penetrant.

Uses

Potent, selective H3 histamine receptor agonist which crosses the blood-brain barrier; inhibits histamine synthesis and release.

Biochem/physiol Actions

Potent, selective H3 histamine receptor agonist which crosses the blood-brain barrier; inhibits histamine synthesis and release.

in vivo

Pretreatment with (R)-(-)-α-Methylhistamine dihydrochloride (RAMH; 10 mg/kg; i.p.; 60 min before training) reverses Propofol‐induced (25 mg/kg; i.p.; 30 min before training) memory retention^[5].
? (R)-(-)-α-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level^[3].

Animal Model:	Male Sprague‐Dawley rats (10-12 week)^[3]
Dosage:	10 mg/kg
Administration:	IP; 60 min before training
Result:	Reversed propofol‐induced memory retention.

IC 50

H₃ receptor: 50.3 nM (Kd)

HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL Preparation Products And Raw materials

Raw materials

Preparation Products

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HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL Suppliers

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75614-89-0, HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYLRelated Search:

Histamine dihydrochloride

HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL

R-(-)-2-(1H-Imidazol-4-yl)-1-methyl-ethylamine dihydrochloride

(R)-1-(1H-Imidazol-4-yl)propan-2-amine dihydrochloride

R-()-α-Methylhistamine (hydrochloride)

R-(?)-α-Methylhistamine hydrochloride

R(-)-α-Methyl Histamine Dihydrochloride

(R)()-α-Methylhistamine

(R)()αMethylhistamine dihydrochloride,(R) ( ) α Methylhistamine dihydrochloride

(R)-2-(1H-Imidazol-4-yl)-1-methyl-ethylamine hydrochloride

(R)-(-)-α-Methylhistamine 2HCl

75614-89-0

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