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Vasonatrin Peptide (VNP)

Product Name
Vasonatrin Peptide (VNP)
CAS No.
141676-35-9
Chemical Name
Vasonatrin Peptide (VNP)
Synonyms
Vasonatrin Peptide (VNP);Vasonatrin Peptide (VNP) Trifluoroacetate;H-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH;GLY-LEU-SER-LYS-GLY-CYS-PHE-GLY-LEU-LYS-LEU-ASP-ARG-ILE-GLY-SER-MET-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR ((DISULFIDE BRIDGE: CYS6-CYS22);L-Tyrosine, glycyl-L-leucyl-L-seryl-L-lysylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-seryl-L-methionyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-, cyclic (6→22)-disulfide
CBNumber
CB7998982
Molecular Formula
C124H198N36O36S3
Formula Weight
2865.34
MOL File
141676-35-9.mol
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Vasonatrin Peptide (VNP) Property

Density 
1.47±0.1 g/cm3(Predicted)
Sequence
Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys6-Cys22)
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Hazard and Precautionary Statements (GHS)

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Vasonatrin Peptide (VNP) Chemical Properties,Usage,Production

Uses

Vasonatrin Peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway[1][2][3].

in vivo

Vasonatrin peptide (100 μg/kg; i.v. ; 10 min before reperfusion) attenuates myocardial ischemia-reperfusion injury in diabetic rats[3].

Animal Model:High-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats[3]
Dosage:100 μg/kg
Administration:I.v. ; 10 min before reperfusion
Result:Significantly improved the instantaneous first derivation of left ventricle pressure (±LV dP/dtmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Inhibited endoplasmic reticulum (ER) stress by suppressing glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP).

References

[1] Wei CM, et al. Vasonatrin peptide: a unique synthetic natriuretic and vasorelaxing peptide. J Clin Invest. 1993;92(4):2048-2052. DOI:10.1172/JCI116800
[2] Chen BY, et al. Vasonatrin peptide, a new regulator of adiponectin and interleukin-6 production in adipocytes. J Endocrinol Invest. 2011;34(10):742-746. DOI:10.3275/7727
[3] Shi Z, et al. Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms. Am J Physiol Heart Circ Physiol. 2015;308(4):H281-H290. DOI:10.1152/ajpheart.00666.2014

Vasonatrin Peptide (VNP) Preparation Products And Raw materials

Raw materials

Preparation Products

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Vasonatrin Peptide (VNP) Suppliers

China 43 United States 5 Global 48
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
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China
ProdList
9981
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Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
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China
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42934
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Chemsky (shanghai) International Co.,Ltd
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021-50135380
Email
shchemsky@sina.com
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China
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15402
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60
Cellmano Biotech Limited
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0551-65326643 18156095617
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0551-65326641
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info@cellmano.com
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China
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1010
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BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
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United States
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12952
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Creative Peptides
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Email
info@creative-peptides.com
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United States
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Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 15951641583
Fax
025-58361106-806
Email
zhao.xu@njpeptide.com
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China
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9979
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Chengdu Youngshe Chemical Co., Ltd.
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+86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
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China
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4802
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Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com
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China
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7408
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Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
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China
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3061
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58

141676-35-9, Vasonatrin Peptide (VNP) Related Search:

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  • Vasonatrin Peptide (VNP)
  • GLY-LEU-SER-LYS-GLY-CYS-PHE-GLY-LEU-LYS-LEU-ASP-ARG-ILE-GLY-SER-MET-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR ((DISULFIDE BRIDGE: CYS6-CYS22)
  • H-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH
  • L-Tyrosine, glycyl-L-leucyl-L-seryl-L-lysylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-seryl-L-methionyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-, cyclic (6→22)-disulfide
  • Vasonatrin Peptide (VNP) Trifluoroacetate
  • 141676-35-9
  • C124H198N36O36S3