4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE
- Product Name
- 4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE
- CAS No.
- 29608-05-7
- Chemical Name
- 4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE
- Synonyms
- AKOS B014375;AKOS MSC-0180;ASISCHEM W54645;ART-CHEM-BB B014375;ART-CHEM-BB B016020;TIMTEC-BB SBB007056;4-(Piperidylmethyl)aniline;1-(4-Aminobenzyl)piperidine;4-(1-piperidylmethyl)aniline;4-(Piperidylmethyl)phenylamine
- CBNumber
- CB8100924
- Molecular Formula
- C12H18N2
- Formula Weight
- 190.28
- MOL File
- 29608-05-7.mol
4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE Property
- Melting point:
- 90-93
- Boiling point:
- 308.7±17.0 °C(Predicted)
- Density
- 1.068±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- crystalline powder
- pka
- 9?+-.0.10(Predicted)
- color
- Brown
- CAS DataBase Reference
- 29608-05-7(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Hazard Note
- Corrosive/Harmful
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- BBO000689
- Product name
- 4-Piperidin-1-ylmethyl-phenylamine
- Packaging
- 1 g
- Price
- $185
- Updated
- 2025/07/31
- Product number
- B448878
- Product name
- 4-(Piperidin-1-ylmethyl)aniline
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- R145
- Product name
- 1-Benzyl-piperidin-4-ylamine
- Packaging
- 250mg
- Price
- $66
- Updated
- 2021/12/16
- Product number
- CHM0026510
- Product name
- 4-(PIPERIDIN-1-YLMETHYL)ANILINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $185.85
- Updated
- 2021/12/16
- Product number
- 3H30-1-3X
- Product name
- 4-(Piperidin-1-ylmethyl)aniline
- Purity
- 97%
- Packaging
- 5G
- Price
- $328
- Updated
- 2021/12/16
4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE Chemical Properties,Usage,Production
Synthesis
59507-44-7
29608-05-7
General procedure for the synthesis of 4-piperidine-1-methylaniline from 1-(4-nitrobenzyl)piperidine: To a solution of anhydrous THF (3 mL) with 4-nitrobenzyl chloride (1 mmol) was added 1-methylpiperazine or piperidine (1 mmol) and triethylamine (1.5 mmol, 0.21 mL) in sequence. The reaction mixture was stirred at 70 °C overnight. Upon completion of the reaction, extraction was carried out with dichloromethane and water. The organic phases were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure to remove the solvent. The residue was purified by column chromatography (eluent: hexane/ethyl acetate, 1:4) and structurally characterized by 1H NMR (see Supplementary Information). The purified product was dissolved in ethanol (10 mL) and PtO2 (0.01 g) was added under nitrogen protection. Hydrogenation was carried out in a Parr hydrogenation unit at 50 psi hydrogen pressure for 16 hours. At the end of the reaction, the catalyst was removed by filtration and the filtrate was concentrated in vacuum to give the target product 4-piperidine-1-methylaniline in quantitative yield.
References
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2917 - 2929
[2] RSC Advances, 2015, vol. 5, # 58, p. 47125 - 47130
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 20, p. 9409 - 9421
[4] Patent: CN106432235, 2017, A. Location in patent: Paragraph 0113
[5] Patent: WO2006/12135, 2006, A1. Location in patent: Page/Page column 54-56
4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE manufacturers
- Product
- 4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE 29608-05-7
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10
- Product
- 4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE 29608-05-7
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10