(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID
- Product Name
- (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID
- CAS No.
- 89396-94-1
- Chemical Name
- (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID
- Synonyms
- TA 6366;Novaloc;SH-6366;Novarok;Tanapril;Tanatril;ACE/TA-6366;IMipadril HCl;Imidaprilhydrochloride;Imidapril HCl (TA-6366)
- CBNumber
- CB81009271
- Molecular Formula
- C20H27N3O6
- Formula Weight
- 405.44488
- MOL File
- 89396-94-1.mol
(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID Property
- Melting point:
- 214-216℃
- alpha
- D20 -64.1° (c = 0.5 in ethanol)
- storage temp.
- -20°C
- solubility
- H2O: ≥5mg/mL
- form
- powder
- color
- white to tan
- optical activity
- [α]/D -50 to -70° in ethanol (c=0.5)
- Merck
- 14,4911
Safety
- WGK Germany
- 3
- RTECS
- NI8927400
- HS Code
- 2933.29.4300
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- SML0148
- Product name
- Imidapril hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $77.4
- Updated
- 2024/03/01
- Product number
- SML0148
- Product name
- Imidapril hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $505
- Updated
- 2024/03/01
- Product number
- I0901
- Product name
- Imidapril Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25mg
- Price
- $126
- Updated
- 2024/03/01
- Product number
- I0901
- Product name
- Imidapril Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 100mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- H37392
- Product name
- Imidapril (hydrochloride)
- Purity
- 98%
- Packaging
- 1g
- Price
- $437.65
- Updated
- 2024/03/01
(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
Imidapril hydrochloride was used as a standard in bioequivalence test by LC/MS method.
Uses
Angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.
Uses
antibiotic
Definition
ChEBI: Imidapril hydrochloride is a dipeptide.
General Description
Imidapril comprises large acyl moiety and is hydrolyzed by carboxylesterase (CES) 1.
Biochem/physiol Actions
Imidapril is a potent angiotensin converting enzyme inhibitor and anti-hypertensive.
Clinical Use
Angiotensin-converting enzyme inhibitor:
Hypertension
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and
increased risk of renal impairment with NSAIDs;
hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia,
hypotension and renal failure with ARBs and
aliskiren.
Bee venom extract: possible severe anaphylactoid
reactions when used together.
Ciclosporin: increased risk of hyperkalaemia and
nephrotoxicity.
Cytotoxics: increased risk of angioedema with
everolimus.
Diuretics: enhanced hypotensive effect;
hyperkalaemia with potassium-sparing diuretics.
ESAs: increased risk of hyperkalaemia; antagonism
of hypotensive effect.
Gold: flushing and hypotension with sodium
aurothiomalate.
Lithium: reduced excretion, possibility of enhanced
lithium toxicity.
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and
nephrotoxicity.
Metabolism
Imidapril is a prodrug, and is metabolised in the liver
to the diacid imidaprilat, its active metabolite. The
bioavailability of imidaprilat is about 42% after oral doses
of imidapril.
About 40% of an oral dose is excreted in the urine, the
rest in the faeces.
(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID Suppliers
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View Lastest Price from (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID manufacturers
- Product
- Imidapril hydrochloride 89396-94-1
- Price
- US $150.00/ASSAYS
- Min. Order
- 10g
- Purity
- >99%
- Supply Ability
- 500kg/month
- Release date
- 2021-10-09
- Product
- (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID 89396-94-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-10
- Product
- (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID 89396-94-1
- Price
- US $33.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2019-07-09